TY - JOUR
T1 - Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma
T2 - Morphological significance of calponin h1
AU - Hayashi, Takuma
AU - Horiuchi, Akiko
AU - Sano, Kenji
AU - Hiraoka, Nobuyoshi
AU - Kasai, Mari
AU - Ichimura, Tomoyuki
AU - Sudo, Tamotsu
AU - Nishimura, Ryuichiro
AU - Ishiko, Osamu
AU - Shiozawa, Tanri
AU - Kanai, Yae
AU - Yaegashi, Nobuo
AU - Aburatani, Hiroyuki
AU - Konishi, Ikuo
PY - 2012/6/21
Y1 - 2012/6/21
N2 - Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that although calponin h1 does not directly influence tumorigenesis, it clearly affects LMP2-induced cellular morphological changes. Modulation of LMP2 may lead to new therapeutic approaches in human uterine LMS.
AB - Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that although calponin h1 does not directly influence tumorigenesis, it clearly affects LMP2-induced cellular morphological changes. Modulation of LMP2 may lead to new therapeutic approaches in human uterine LMS.
UR - http://www.scopus.com/inward/record.url?scp=84862489848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862489848&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2012.05.029
DO - 10.1016/j.febslet.2012.05.029
M3 - Article
C2 - 22659265
AN - SCOPUS:84862489848
SN - 0014-5793
VL - 586
SP - 1824
EP - 1831
JO - FEBS Letters
JF - FEBS Letters
IS - 13
ER -