TY - JOUR
T1 - Potential therapeutic system for Alzheimer's disease
T2 - Removal of blood Aβs by hemodialzyers and its effect on the cognitive functions of renal-failure patients
AU - Kato, Masao
AU - Kawaguchi, Kazunori
AU - Nakai, Sigeru
AU - Murakami, Kazutaka
AU - Hori, Hideo
AU - Ohashi, Atsushi
AU - Hiki, Yoshiyuki
AU - Ito, Shinji
AU - Shimano, Yasunobu
AU - Suzuki, Nobuo
AU - Sugiyama, Satoshi
AU - Ogawa, Hiroshi
AU - Kusimoto, Hiroko
AU - Mutoh, Tatsuro
AU - Yuzawa, Yukio
AU - Kitaguchi, Nobuya
N1 - Funding Information:
The authors sincerely thank Dr. Shigenobu Nakamura for his fruitful discussions. The authors also thank Ms. Yukari Murata and Sachi Oguri for their technical assistance. This work was partly supported by KAKENHI (20509008 and 23500531) and the Smoking Research Foundation.
PY - 2012/12
Y1 - 2012/12
N2 - The pathological changes of Alzheimer's disease include the deposition of amyloid β protein (Aβ) as senile plaques in the brain. We hypothesized that the rapid removal of Aβs from the blood may act as a peripheral Aβ drainage sink from the brain. In this study, the plasma Aβ concentrations and the cognitive functions were investigated for in 57 patients on hemodailysis (69.4 ± 3.8 years), 26 renal-failure patients without hemodialysis (66.6 ± 14.7 years), and 17 age-matched healthy controls (66.6 ± 4.1 years). The concentrations of plasma Aβs increased along with the decline of renal functions. Moreover, the renal-failure patients without hemodialysis and with poorer renal functions showed lower cognitive functions. The plasma concentrations of Aβ1-42 correlated with serum creatinine (P < 0.001) and Mini-Mental-State Examination scores (P = 0.017). The dialyzers effectively removed Aβs in the blood during hemodialysis sessions. The plasma Aβ concentrations showed steady or slightly decreasing along with duration of hemodialysis. The total amount of Aβs removed during a hemodialysis session was calculated to be comparable to the Aβs dissolved in the blood and the cerebrospinal fluid. The MMSE scores of the hemodialysis patients showed no clear decrease in longer hemodialysis duration. Therefore, the therapeutic approach for Alzheimer's disease by removing Aβs from the blood is worthy of further investigation, including whether or not Aβs in the brain decrease.
AB - The pathological changes of Alzheimer's disease include the deposition of amyloid β protein (Aβ) as senile plaques in the brain. We hypothesized that the rapid removal of Aβs from the blood may act as a peripheral Aβ drainage sink from the brain. In this study, the plasma Aβ concentrations and the cognitive functions were investigated for in 57 patients on hemodailysis (69.4 ± 3.8 years), 26 renal-failure patients without hemodialysis (66.6 ± 14.7 years), and 17 age-matched healthy controls (66.6 ± 4.1 years). The concentrations of plasma Aβs increased along with the decline of renal functions. Moreover, the renal-failure patients without hemodialysis and with poorer renal functions showed lower cognitive functions. The plasma concentrations of Aβ1-42 correlated with serum creatinine (P < 0.001) and Mini-Mental-State Examination scores (P = 0.017). The dialyzers effectively removed Aβs in the blood during hemodialysis sessions. The plasma Aβ concentrations showed steady or slightly decreasing along with duration of hemodialysis. The total amount of Aβs removed during a hemodialysis session was calculated to be comparable to the Aβs dissolved in the blood and the cerebrospinal fluid. The MMSE scores of the hemodialysis patients showed no clear decrease in longer hemodialysis duration. Therefore, the therapeutic approach for Alzheimer's disease by removing Aβs from the blood is worthy of further investigation, including whether or not Aβs in the brain decrease.
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U2 - 10.1007/s00702-012-0844-5
DO - 10.1007/s00702-012-0844-5
M3 - Article
C2 - 22699459
AN - SCOPUS:84878365343
SN - 0300-9564
VL - 119
SP - 1533
EP - 1544
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 12
ER -
