Potential therapeutic target for pulmonary arterial hypertension--osteopontin

Yasushi Hoshikawa, Yasushi Matsuda, Masahito Sakuma, Takashi Kondo

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Microarray analysis demonstrated lung gene encoding osteopontin (OPN), a soluble secreted phosphoprotein, was significantly elevated in rats with hypoxic pulmonary arterial hypertension (PAH). Since OPN enhances vascular smooth muscle cell proliferation, we hypothesized that OPN played a role in the pathogenesis of PAH. Some patients with idiopathic PAH showed increased expression of plasma OPN and lung OPN gene. OPN overexpression in mice caused pronounced pulmonary hypertension and vascular remodeling under hypoxic conditions. A PPARgamma ligand, pioglitazone, which was reported to inhibit OPN gene expression in vitro, attenuated hypoxia-induced increase in lung OPN gene and pulmonary vascular remodeling in rats. These findings indicate that OPN may be responsible for pulmonary vascular remodeling and could be a therapeutic target for PAH.

Original languageEnglish
Pages (from-to)2097-2101
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Volume66
Issue number11
Publication statusPublished - 01-01-2008

Fingerprint

Osteopontin
Pulmonary Hypertension
Lung
Therapeutics
pioglitazone
Genes
PPAR gamma
Phosphoproteins
Microarray Analysis
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Proliferation
Ligands
Gene Expression

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hoshikawa, Yasushi ; Matsuda, Yasushi ; Sakuma, Masahito ; Kondo, Takashi. / Potential therapeutic target for pulmonary arterial hypertension--osteopontin. In: Nippon rinsho. Japanese journal of clinical medicine. 2008 ; Vol. 66, No. 11. pp. 2097-2101.
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Potential therapeutic target for pulmonary arterial hypertension--osteopontin. / Hoshikawa, Yasushi; Matsuda, Yasushi; Sakuma, Masahito; Kondo, Takashi.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 66, No. 11, 01.01.2008, p. 2097-2101.

Research output: Contribution to journalReview article

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