TY - JOUR
T1 - Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin
AU - Hiramatsu, Masayuki
AU - Nabeshima, Toshitaka
AU - Fukaya, Hiroaki
AU - Furukawa, Hiroshi
N1 - Funding Information:
This study was supported in part by grants-in-aid from The Ishida Foundation (No. 59-292), The Mochida Memorial Foundation for Medical and Pharmaceutical Research (No. 59-2-7) and The Research Foundation for Pharmaceutical Sciences (No. 59-1-12). We thank Mr. K. Yamaguchi, Nihon Bioresearch Center Inc., for the supply of animals. Bestatin was generously supplied by Dr. T. Aoyagi (Institute of Microbial Chemistry of Tokyo).
PY - 1986/1/14
Y1 - 1986/1/14
N2 - We investigate the effects of thiorphan, a specific inhibitor of enkephalinase A and bestatin, a specific inhibitor of aminopeptidase, on the stereotyped behaviors induced by phencyclidine (PCP) in cannulated rats. The PCP-induced turning was significantly potentiated when thiorphan (50 μg) and bestatin (50 μg) were injected simultaneously into the rat lateral ventricle. The increase of PCP-induced turning was completely antagonized by the pretreatment with naloxone. Thiorphan (50 μg) or bestatin (50 μg) alone failed to potentiate PCP-induced turning. Thiorphan and/or bestatin did not affect significantly the PCP-induced head weaving and back-pedalling except that thiorphan (50 μg) potentiated the PCP-induced head weaving 15-18 min after the PCP injection. The combination of thiorphan and bestatin alone did not induce any behavioral change. These results suggest that thiorphan and bestatin produce an increase of endogenous enkephalins and that as a result, PCP-induced turning may be enhanced.
AB - We investigate the effects of thiorphan, a specific inhibitor of enkephalinase A and bestatin, a specific inhibitor of aminopeptidase, on the stereotyped behaviors induced by phencyclidine (PCP) in cannulated rats. The PCP-induced turning was significantly potentiated when thiorphan (50 μg) and bestatin (50 μg) were injected simultaneously into the rat lateral ventricle. The increase of PCP-induced turning was completely antagonized by the pretreatment with naloxone. Thiorphan (50 μg) or bestatin (50 μg) alone failed to potentiate PCP-induced turning. Thiorphan and/or bestatin did not affect significantly the PCP-induced head weaving and back-pedalling except that thiorphan (50 μg) potentiated the PCP-induced head weaving 15-18 min after the PCP injection. The combination of thiorphan and bestatin alone did not induce any behavioral change. These results suggest that thiorphan and bestatin produce an increase of endogenous enkephalins and that as a result, PCP-induced turning may be enhanced.
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U2 - 10.1016/0014-2999(86)90641-2
DO - 10.1016/0014-2999(86)90641-2
M3 - Article
C2 - 3456306
AN - SCOPUS:0022649210
SN - 0014-2999
VL - 120
SP - 69
EP - 74
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -