Pre-procedural thrombolysis in myocardial infarction flow in patients with ST-segment elevation myocardial infarction a j-minuet substudy

J-MINUET investigators

Research output: Contribution to journalArticle

Abstract

It has been shown that the patency of an infarct-related artery (IRA) before primary percutaneous coronary intervention determines post-procedural success, better preservation of left ventricular function, and lower in-hospital mortality. However, the factors associated with pre-procedural Thrombolysis In Myocardial Infarction (TIMI) flow have not been fully investigated. The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective multicenter registry conducted at 28 Japanese medical institutions between July 2012 and March 2014. We enrolled 3,283 consecutive patients with acute myocardial infarction who were admitted to a participating institution within 48 hours of symptom onset. There were 2,262 patients (68.9%) with ST-elevation myocardial infarction (STEMI), among whom 2,182 patients underwent emergent or urgent coronary angiography. Pre-procedural TIMI flow grade 3 was related to post-procedural TIMI flow grade 3 (P < 0.001), lower enzymatic infarct size (P < 0.001), lower ventricular tachycardia and ventricular fibrillation (P = 0.049), and lower in-hospital mortality (P = 0.020). A history of antiplatelet drug use was associated with pre-procedural TIMI flow. Antiplatelet drug use on admission was associated with pre-procedural TIMI flow. The patency of the IRA in patients with STEMI was related to procedural success and decreased enzymatic infarct size, fatal arrhythmic events, and in-hospital mortality.

Original languageEnglish
Pages (from-to)920-925
Number of pages6
JournalInternational heart journal
Volume59
Issue number5
DOIs
Publication statusPublished - 01-01-2018

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Myocardial Infarction
Hospital Mortality
Platelet Aggregation Inhibitors
Registries
Arteries
Ventricular Fibrillation
Percutaneous Coronary Intervention
Ventricular Tachycardia
ST Elevation Myocardial Infarction
Coronary Angiography
Left Ventricular Function

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{06b552df69014e6ba5ebb3d320019351,
title = "Pre-procedural thrombolysis in myocardial infarction flow in patients with ST-segment elevation myocardial infarction a j-minuet substudy",
abstract = "It has been shown that the patency of an infarct-related artery (IRA) before primary percutaneous coronary intervention determines post-procedural success, better preservation of left ventricular function, and lower in-hospital mortality. However, the factors associated with pre-procedural Thrombolysis In Myocardial Infarction (TIMI) flow have not been fully investigated. The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective multicenter registry conducted at 28 Japanese medical institutions between July 2012 and March 2014. We enrolled 3,283 consecutive patients with acute myocardial infarction who were admitted to a participating institution within 48 hours of symptom onset. There were 2,262 patients (68.9{\%}) with ST-elevation myocardial infarction (STEMI), among whom 2,182 patients underwent emergent or urgent coronary angiography. Pre-procedural TIMI flow grade 3 was related to post-procedural TIMI flow grade 3 (P < 0.001), lower enzymatic infarct size (P < 0.001), lower ventricular tachycardia and ventricular fibrillation (P = 0.049), and lower in-hospital mortality (P = 0.020). A history of antiplatelet drug use was associated with pre-procedural TIMI flow. Antiplatelet drug use on admission was associated with pre-procedural TIMI flow. The patency of the IRA in patients with STEMI was related to procedural success and decreased enzymatic infarct size, fatal arrhythmic events, and in-hospital mortality.",
author = "{J-MINUET investigators} and Takuya Hashimoto and Junya Ako and Koichi Nakao and Yukio Ozaki and Kazuo Kimura and Teruo Noguchi and Satoshi Yasuda and Satoru Suwa and Kazuteru Fujimoto and Yasuharu Nakama and Takashi Morita and Wataru Shimizu and Yoshihiko Saito and Atsushi Hirohata and Yasuhiro Morita and Teruo Inoue and Atsunori Okamura and Masaaki Uematsu and Kazuhito Hirata and Kengo Tanabe and Yoshisato Shibata and Mafumi Owa and Kenichi Tsujita and Hiroshi Funayama and Nobuaki Kokubu and Ken Kozuma and Shirou Uemura and Tetsuya Toubaru and Keijirou Saku and Shigeru Oshima and Michikazu Nakai and Kunihiro Nishimura and Yoshihiro Miyamoto and Hisao Ogawa and Masaharu Ishihara",
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language = "English",
volume = "59",
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Pre-procedural thrombolysis in myocardial infarction flow in patients with ST-segment elevation myocardial infarction a j-minuet substudy. / J-MINUET investigators.

In: International heart journal, Vol. 59, No. 5, 01.01.2018, p. 920-925.

Research output: Contribution to journalArticle

TY - JOUR

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AU - J-MINUET investigators

AU - Hashimoto, Takuya

AU - Ako, Junya

AU - Nakao, Koichi

AU - Ozaki, Yukio

AU - Kimura, Kazuo

AU - Noguchi, Teruo

AU - Yasuda, Satoshi

AU - Suwa, Satoru

AU - Fujimoto, Kazuteru

AU - Nakama, Yasuharu

AU - Morita, Takashi

AU - Shimizu, Wataru

AU - Saito, Yoshihiko

AU - Hirohata, Atsushi

AU - Morita, Yasuhiro

AU - Inoue, Teruo

AU - Okamura, Atsunori

AU - Uematsu, Masaaki

AU - Hirata, Kazuhito

AU - Tanabe, Kengo

AU - Shibata, Yoshisato

AU - Owa, Mafumi

AU - Tsujita, Kenichi

AU - Funayama, Hiroshi

AU - Kokubu, Nobuaki

AU - Kozuma, Ken

AU - Uemura, Shirou

AU - Toubaru, Tetsuya

AU - Saku, Keijirou

AU - Oshima, Shigeru

AU - Nakai, Michikazu

AU - Nishimura, Kunihiro

AU - Miyamoto, Yoshihiro

AU - Ogawa, Hisao

AU - Ishihara, Masaharu

PY - 2018/1/1

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