Precancerous conditions of biliary tract cancer in patients with pancreaticobiliary malfunction: Reappraisal of nationwide survey in Japan

Akitake Hasumi, Hideo Matsui, Atsushi Sugioka, Ichiro Uyama, Yoshiyuki Komoki, Junko Fujita, Hakuo Aoki

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

It is widely known that pancreaticobiliary maljunction (PBM), an anomalous arrangement of the pancreaticobiliary ductal system, is frequently associated with biliary tract cancer in patients with or without bile duct dilatation. In 1985. we surveyed patients with PBM who had been operated on at 133 Japanese institutions. A close relationship was shown between biliary tract carcinogenesis and PBM, according to the type of maljunction and age distribution: PBM patients with cystic dilatation had a high risk of bile duct cancer, even in those who were young (aged less than 20 years); the incidence of gallbladder cancer increased markedly in PBM patients over 40 years old with cystic dilatation, while it gradually increased with age in the PBM patients without cystic dilatation. Therefore, we recommend surgical treatment lor patients with PBM even if they have no symptoms.

Original languageEnglish
Pages (from-to)551-555
Number of pages5
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume7
Issue number6
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology

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