Preclinical study of boron neutron capture therapy for bone metastasis using human breast cancer cell lines

Tooru Andoh; Takuya Fujimoto; Ryoichi Satani; Minoru Suzuki; Keijiro Wada; Tamotsu Sudo; Yoshinori Sakurai; Hiroki Tanaka; Takushi Takata; Hideki Ichikawa

doi:10.1016/j.apradiso.2020.109257

Preclinical study of boron neutron capture therapy for bone metastasis using human breast cancer cell lines

Tooru Andoh, Takuya Fujimoto, Ryoichi Satani, Minoru Suzuki, Keijiro Wada, Tamotsu Sudo, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Hideki Ichikawa

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Bone metastasis has a major impact on the quality of life that general therapy cannot control. We established a bone metastasis model with a human breast cancer cell line and investigated the therapeutic effect of boron neutron capture therapy (BNCT). BNCT suppressed tumor growth in cases of intramedullary small tumors without damaging normal tissues, providing preliminary evidence that it is a potentially new therapeutic option for controlling tumor growth from bone metastasis. Further research is warranted for its clinical application.

Original language	English
Article number	109257
Journal	Applied Radiation and Isotopes
Volume	165
DOIs	https://doi.org/10.1016/j.apradiso.2020.109257
Publication status	Published - 11-2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.apradiso.2020.109257

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title = "Preclinical study of boron neutron capture therapy for bone metastasis using human breast cancer cell lines",

abstract = "Bone metastasis has a major impact on the quality of life that general therapy cannot control. We established a bone metastasis model with a human breast cancer cell line and investigated the therapeutic effect of boron neutron capture therapy (BNCT). BNCT suppressed tumor growth in cases of intramedullary small tumors without damaging normal tissues, providing preliminary evidence that it is a potentially new therapeutic option for controlling tumor growth from bone metastasis. Further research is warranted for its clinical application.",

author = "Tooru Andoh and Takuya Fujimoto and Ryoichi Satani and Minoru Suzuki and Keijiro Wada and Tamotsu Sudo and Yoshinori Sakurai and Hiroki Tanaka and Takushi Takata and Hideki Ichikawa",

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doi = "10.1016/j.apradiso.2020.109257",

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T1 - Preclinical study of boron neutron capture therapy for bone metastasis using human breast cancer cell lines

AU - Andoh, Tooru

AU - Fujimoto, Takuya

AU - Satani, Ryoichi

AU - Suzuki, Minoru

AU - Wada, Keijiro

AU - Sudo, Tamotsu

AU - Sakurai, Yoshinori

AU - Tanaka, Hiroki

AU - Takata, Takushi

AU - Ichikawa, Hideki

PY - 2020/11

Y1 - 2020/11

N2 - Bone metastasis has a major impact on the quality of life that general therapy cannot control. We established a bone metastasis model with a human breast cancer cell line and investigated the therapeutic effect of boron neutron capture therapy (BNCT). BNCT suppressed tumor growth in cases of intramedullary small tumors without damaging normal tissues, providing preliminary evidence that it is a potentially new therapeutic option for controlling tumor growth from bone metastasis. Further research is warranted for its clinical application.

AB - Bone metastasis has a major impact on the quality of life that general therapy cannot control. We established a bone metastasis model with a human breast cancer cell line and investigated the therapeutic effect of boron neutron capture therapy (BNCT). BNCT suppressed tumor growth in cases of intramedullary small tumors without damaging normal tissues, providing preliminary evidence that it is a potentially new therapeutic option for controlling tumor growth from bone metastasis. Further research is warranted for its clinical application.

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AN - SCOPUS:85089145009

SN - 0969-8043

VL - 165

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 109257

ER -

Preclinical study of boron neutron capture therapy for bone metastasis using human breast cancer cell lines

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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