Preclinical study of boron neutron capture therapy for bone metastasis using human breast cancer cell lines

Tooru Andoh, Takuya Fujimoto, Ryoichi Satani, Minoru Suzuki, Keijiro Wada, Tamotsu Sudo, Yoshinori Sakurai, Hiroki Tanaka, Takushi Takata, Hideki Ichikawa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Bone metastasis has a major impact on the quality of life that general therapy cannot control. We established a bone metastasis model with a human breast cancer cell line and investigated the therapeutic effect of boron neutron capture therapy (BNCT). BNCT suppressed tumor growth in cases of intramedullary small tumors without damaging normal tissues, providing preliminary evidence that it is a potentially new therapeutic option for controlling tumor growth from bone metastasis. Further research is warranted for its clinical application.

Original languageEnglish
Article number109257
JournalApplied Radiation and Isotopes
Volume165
DOIs
Publication statusPublished - 11-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation

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