Predatory Bacteria: A Potential Ally against Multidrug-Resistant Gram-Negative Pathogens

Daniel E. Kadouri, Kevin To, Robert M.Q. Shanks, Yohei Doi

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Multidrug-resistant (MDR) Gram-negative bacteria have emerged as a serious threat to human and animal health. Bdellovibrio spp. and Micavibrio spp. are Gram-negative bacteria that prey on other Gram-negative bacteria. In this study, the ability of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus to prey on MDR Gram-negative clinical strains was examined. Although the potential use of predatory bacteria to attack MDR pathogens has been suggested, the data supporting these claims is lacking. By conducting predation experiments we have established that predatory bacteria have the capacity to attack clinical strains of a variety of ß-lactamase-producing, MDR Gram-negative bacteria. Our observations indicate that predatory bacteria maintained their ability to prey on MDR bacteria regardless of their antimicrobial resistance, hence, might be used as therapeutic agents where other antimicrobial drugs fail.

Original languageEnglish
Article numbere63397
JournalPloS one
Volume8
Issue number5
DOIs
Publication statusPublished - 01-05-2013

Fingerprint

Pathogens
Gram-Negative Bacteria
Gram-negative bacteria
Micavibrio
Bacteria
pathogens
bacteria
Bdellovibrio bacteriovorus
Bdellovibrio
animal and human health
Anti-Infective Agents
antibiotic resistance
anti-infective agents
predation
drugs
therapeutics
metsulfuron methyl
Health
Pharmaceutical Preparations
Animals

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kadouri, Daniel E. ; To, Kevin ; Shanks, Robert M.Q. ; Doi, Yohei. / Predatory Bacteria : A Potential Ally against Multidrug-Resistant Gram-Negative Pathogens. In: PloS one. 2013 ; Vol. 8, No. 5.
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Predatory Bacteria : A Potential Ally against Multidrug-Resistant Gram-Negative Pathogens. / Kadouri, Daniel E.; To, Kevin; Shanks, Robert M.Q.; Doi, Yohei.

In: PloS one, Vol. 8, No. 5, e63397, 01.05.2013.

Research output: Contribution to journalArticle

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