Prediction of biochemical recurrence after radical prostatectomy using peritumoral lymphatic vessel density in biopsy specimens in patients with localized prostate cancer

Kenji Kuroda, Akio Horiguchi, Takako Asano, Shinsuke Tasaki, Hidehiko Yoshii, Akinori Sato, Junichi Asakuma, Keiichi Ito, Kenji Seguchi, Makoto Sumitomo, Tomohiko Asano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Lymphatic invasion has been associated with biochemical recurrence (BCR), and many patients with postoperative elevation of prostate-specific antigen (PSA) develop distant metastases within several years. We previously found peritumoral lymphatic vessel density (PTLD) in biopsy cores to be an independent predictor of lymphatic invasion in radical prostatectomy specimens, so we speculate that PTLD parameters in biopsy specimens could also be independent predictors of BCR after surgery. Patients and Methods: We obtained positive biopsy cores from 110 patients who underwent radical prostatectomy at our institution. Biopsy cores were immunostained with the D2-40 monoclonal antibody, which specifically and selectively detects lymphatic endothelium. We evaluated differences between the BCR-free survival rates and used univariate and multivariate analyses to detect independent predictors of BCR. Results: The results of a Cox proportional hazards model showed that lymphatic invasion in prostatectomy specimens was one of the independent postoperative prognostic factors for BCR (p = 0.0338). An additional model showed that one PTLD parameter, maximal PTLD, was among the independent preoperative predictors of lower BCR-free survival rates (p = 0.0200). Conclusions: Information about PTLD in prostate biopsy specimens could be helpful for selecting patients as radical prostatectomy candidates, and patients with high PTLD values should be carefully monitored after surgery.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalUrologia Internationalis
Volume88
Issue number1
DOIs
Publication statusPublished - 01-01-2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Urology

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