Prediction of genetic risk for hypertension

Hideo Izawa, Yoshiji Yamada, Toro Okada, Masashi Tanaka, Haruo Hirayama, Toyoaki Murohara, Mitsuhiro Yokota

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: Although genetic epidemiological studies have suggested that several genetic variants increase the risk for hypertension, the genes that underlie genetic susceptibility to this condition remain to be identified definitively. Large-scale association studies that examine many gene polymorphisms simultaneously are required to predict genetic risk for hypertension. METHODS and RESULTS: The population of the present study comprised 1,940 unrelated Japanese individuals, including 1,067 subjects with hypertension (574 men, 493 women) and 873 controls (533 men, 340 women). The genotypes for 33 single nucleotide polymorphisms of 27 candidate genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that two polymorphisms (825C -> T in the G protein beta3 subunit gene and 190G -> A in the CC chemokine receptor 2 gene) were significantly associated with hypertension in men and that one polymorphism (-238G -> A in the tumor necrosis factor- alpha gene) was significantly associated with hypertension in women. CONCLUSION: These results suggest that two and one genes may be susceptibility loci for hypertension in Japanese men and women, respectively, and that genotyping of these polymorphisms may prove informative for prediction of the genetic risk for hypertension.

Original languageEnglish
Pages (from-to)92-93
Number of pages2
JournalJournal of cardiology
Volume43
Issue number2
Publication statusPublished - 01-02-2004
Externally publishedYes

Fingerprint

Hypertension
Genes
CCR2 Receptors
Colorimetry
Hyperuricemia
DNA Primers
DNA Probes
Genetic Predisposition to Disease
Hypercholesterolemia
Single Nucleotide Polymorphism
Epidemiologic Studies
Diabetes Mellitus
Body Mass Index
Tumor Necrosis Factor-alpha
Fluorescence
Logistic Models
Smoking
Alleles
Genotype
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Izawa, H., Yamada, Y., Okada, T., Tanaka, M., Hirayama, H., Murohara, T., & Yokota, M. (2004). Prediction of genetic risk for hypertension. Journal of cardiology, 43(2), 92-93.
Izawa, Hideo ; Yamada, Yoshiji ; Okada, Toro ; Tanaka, Masashi ; Hirayama, Haruo ; Murohara, Toyoaki ; Yokota, Mitsuhiro. / Prediction of genetic risk for hypertension. In: Journal of cardiology. 2004 ; Vol. 43, No. 2. pp. 92-93.
@article{d46d762542f84850a6ac4faf6503a441,
title = "Prediction of genetic risk for hypertension",
abstract = "BACKGROUND: Although genetic epidemiological studies have suggested that several genetic variants increase the risk for hypertension, the genes that underlie genetic susceptibility to this condition remain to be identified definitively. Large-scale association studies that examine many gene polymorphisms simultaneously are required to predict genetic risk for hypertension. METHODS and RESULTS: The population of the present study comprised 1,940 unrelated Japanese individuals, including 1,067 subjects with hypertension (574 men, 493 women) and 873 controls (533 men, 340 women). The genotypes for 33 single nucleotide polymorphisms of 27 candidate genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that two polymorphisms (825C -> T in the G protein beta3 subunit gene and 190G -> A in the CC chemokine receptor 2 gene) were significantly associated with hypertension in men and that one polymorphism (-238G -> A in the tumor necrosis factor- alpha gene) was significantly associated with hypertension in women. CONCLUSION: These results suggest that two and one genes may be susceptibility loci for hypertension in Japanese men and women, respectively, and that genotyping of these polymorphisms may prove informative for prediction of the genetic risk for hypertension.",
author = "Hideo Izawa and Yoshiji Yamada and Toro Okada and Masashi Tanaka and Haruo Hirayama and Toyoaki Murohara and Mitsuhiro Yokota",
year = "2004",
month = "2",
day = "1",
language = "English",
volume = "43",
pages = "92--93",
journal = "Journal of Cardiology",
issn = "0914-5087",
number = "2",

}

Izawa, H, Yamada, Y, Okada, T, Tanaka, M, Hirayama, H, Murohara, T & Yokota, M 2004, 'Prediction of genetic risk for hypertension', Journal of cardiology, vol. 43, no. 2, pp. 92-93.

Prediction of genetic risk for hypertension. / Izawa, Hideo; Yamada, Yoshiji; Okada, Toro; Tanaka, Masashi; Hirayama, Haruo; Murohara, Toyoaki; Yokota, Mitsuhiro.

In: Journal of cardiology, Vol. 43, No. 2, 01.02.2004, p. 92-93.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prediction of genetic risk for hypertension

AU - Izawa, Hideo

AU - Yamada, Yoshiji

AU - Okada, Toro

AU - Tanaka, Masashi

AU - Hirayama, Haruo

AU - Murohara, Toyoaki

AU - Yokota, Mitsuhiro

PY - 2004/2/1

Y1 - 2004/2/1

N2 - BACKGROUND: Although genetic epidemiological studies have suggested that several genetic variants increase the risk for hypertension, the genes that underlie genetic susceptibility to this condition remain to be identified definitively. Large-scale association studies that examine many gene polymorphisms simultaneously are required to predict genetic risk for hypertension. METHODS and RESULTS: The population of the present study comprised 1,940 unrelated Japanese individuals, including 1,067 subjects with hypertension (574 men, 493 women) and 873 controls (533 men, 340 women). The genotypes for 33 single nucleotide polymorphisms of 27 candidate genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that two polymorphisms (825C -> T in the G protein beta3 subunit gene and 190G -> A in the CC chemokine receptor 2 gene) were significantly associated with hypertension in men and that one polymorphism (-238G -> A in the tumor necrosis factor- alpha gene) was significantly associated with hypertension in women. CONCLUSION: These results suggest that two and one genes may be susceptibility loci for hypertension in Japanese men and women, respectively, and that genotyping of these polymorphisms may prove informative for prediction of the genetic risk for hypertension.

AB - BACKGROUND: Although genetic epidemiological studies have suggested that several genetic variants increase the risk for hypertension, the genes that underlie genetic susceptibility to this condition remain to be identified definitively. Large-scale association studies that examine many gene polymorphisms simultaneously are required to predict genetic risk for hypertension. METHODS and RESULTS: The population of the present study comprised 1,940 unrelated Japanese individuals, including 1,067 subjects with hypertension (574 men, 493 women) and 873 controls (533 men, 340 women). The genotypes for 33 single nucleotide polymorphisms of 27 candidate genes were determined with a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that two polymorphisms (825C -> T in the G protein beta3 subunit gene and 190G -> A in the CC chemokine receptor 2 gene) were significantly associated with hypertension in men and that one polymorphism (-238G -> A in the tumor necrosis factor- alpha gene) was significantly associated with hypertension in women. CONCLUSION: These results suggest that two and one genes may be susceptibility loci for hypertension in Japanese men and women, respectively, and that genotyping of these polymorphisms may prove informative for prediction of the genetic risk for hypertension.

UR - http://www.scopus.com/inward/record.url?scp=2142755289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2142755289&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 92

EP - 93

JO - Journal of Cardiology

JF - Journal of Cardiology

SN - 0914-5087

IS - 2

ER -

Izawa H, Yamada Y, Okada T, Tanaka M, Hirayama H, Murohara T et al. Prediction of genetic risk for hypertension. Journal of cardiology. 2004 Feb 1;43(2):92-93.