Prediction of sudden cardiac death in patients with chronic heart failure by regional washout rate in cardiac MIBG SPECT imaging

Hironori Yamamoto; Takahisa Yamada; Shunsuke Tamaki; Takashi Morita; Yoshio Furukawa; Yusuke Iwasaki; Masato Kawasaki; Atsushi Kikuchi; Takumi Kondo; Tatsuhisa Ozaki; Masahiro Seo; Yoshihiro Sato; Iyo Ikeda; Eiji Fukuhara; Makoto Abe; Jun Nakamura; Masatake Fukunami

doi:10.1007/s12350-017-0913-0

Prediction of sudden cardiac death in patients with chronic heart failure by regional washout rate in cardiac MIBG SPECT imaging

Hironori Yamamoto, Takahisa Yamada, Shunsuke Tamaki, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tatsuhisa Ozaki, Masahiro Seo, Yoshihiro Sato, Iyo Ikeda, Eiji Fukuhara, Makoto Abe, Jun Nakamura, Masatake Fukunami

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: The sympathetic nervous system provides an important trigger for major arrhythmic events through regional heterogeneity of sympathetic activity, which could be evaluated by SPECT imaging as the regional MIBG washout rate (WR). There is little information available on the prognostic value of regional WR in SPECT imaging for the prediction of sudden cardiac death (SCD) in patients with chronic heart failure (CHF). Methods: We studied 73 CHF outpatients with LVEF < 40%. At study entry, the regional WR was measured in 17 segments on the polar map. We defined abnormal regional WR as both the regional WR range (maximum − minimum regional WR) and maximum regional WR > mean value + 2SD obtained in 15 normal controls. Results: During a mean follow-up of 7.5 ± 4.1 years, 15 of 73 patients had SCD. The abnormal regional WR and abnormal global WR on planar images were significantly and independently associated with SCD. Patients with both the abnormal regional WR and global WR had a significantly higher risk of SCD than those with none of these criteria. Conclusions: The analysis of regional MIBG WR on SPECT imaging provides additional prognostic value to global WR on planar images for SCD prediction in CHF patients.

Original language	English
Pages (from-to)	109-117
Number of pages	9
Journal	Journal of Nuclear Cardiology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1007/s12350-017-0913-0
Publication status	Published - 15-02-2019
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1007/s12350-017-0913-0

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Yamamoto, H., Yamada, T., Tamaki, S., Morita, T., Furukawa, Y., Iwasaki, Y., Kawasaki, M., Kikuchi, A., Kondo, T., Ozaki, T., Seo, M., Sato, Y., Ikeda, I., Fukuhara, E., Abe, M., Nakamura, J., & Fukunami, M. (2019). Prediction of sudden cardiac death in patients with chronic heart failure by regional washout rate in cardiac MIBG SPECT imaging. Journal of Nuclear Cardiology, 26(1), 109-117. https://doi.org/10.1007/s12350-017-0913-0

@article{d9b8fe6562c14551878278d3679b4268,

title = "Prediction of sudden cardiac death in patients with chronic heart failure by regional washout rate in cardiac MIBG SPECT imaging",

abstract = "Background: The sympathetic nervous system provides an important trigger for major arrhythmic events through regional heterogeneity of sympathetic activity, which could be evaluated by SPECT imaging as the regional MIBG washout rate (WR). There is little information available on the prognostic value of regional WR in SPECT imaging for the prediction of sudden cardiac death (SCD) in patients with chronic heart failure (CHF). Methods: We studied 73 CHF outpatients with LVEF < 40%. At study entry, the regional WR was measured in 17 segments on the polar map. We defined abnormal regional WR as both the regional WR range (maximum − minimum regional WR) and maximum regional WR > mean value + 2SD obtained in 15 normal controls. Results: During a mean follow-up of 7.5 ± 4.1 years, 15 of 73 patients had SCD. The abnormal regional WR and abnormal global WR on planar images were significantly and independently associated with SCD. Patients with both the abnormal regional WR and global WR had a significantly higher risk of SCD than those with none of these criteria. Conclusions: The analysis of regional MIBG WR on SPECT imaging provides additional prognostic value to global WR on planar images for SCD prediction in CHF patients.",

keywords = "MIBG imaging, SPECT, heart failure",

author = "Hironori Yamamoto and Takahisa Yamada and Shunsuke Tamaki and Takashi Morita and Yoshio Furukawa and Yusuke Iwasaki and Masato Kawasaki and Atsushi Kikuchi and Takumi Kondo and Tatsuhisa Ozaki and Masahiro Seo and Yoshihiro Sato and Iyo Ikeda and Eiji Fukuhara and Makoto Abe and Jun Nakamura and Masatake Fukunami",

note = "Publisher Copyright: {\textcopyright} 2017, American Society of Nuclear Cardiology.",

year = "2019",

month = feb,

day = "15",

doi = "10.1007/s12350-017-0913-0",

language = "English",

volume = "26",

pages = "109--117",

journal = "Journal of Nuclear Cardiology",

issn = "1071-3581",

publisher = "American Society of Nuclear Cardiology",

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Yamamoto, H, Yamada, T, Tamaki, S, Morita, T, Furukawa, Y, Iwasaki, Y, Kawasaki, M, Kikuchi, A, Kondo, T, Ozaki, T, Seo, M, Sato, Y, Ikeda, I, Fukuhara, E, Abe, M, Nakamura, J & Fukunami, M 2019, 'Prediction of sudden cardiac death in patients with chronic heart failure by regional washout rate in cardiac MIBG SPECT imaging', Journal of Nuclear Cardiology, vol. 26, no. 1, pp. 109-117. https://doi.org/10.1007/s12350-017-0913-0

TY - JOUR

T1 - Prediction of sudden cardiac death in patients with chronic heart failure by regional washout rate in cardiac MIBG SPECT imaging

AU - Yamamoto, Hironori

AU - Yamada, Takahisa

AU - Tamaki, Shunsuke

AU - Morita, Takashi

AU - Furukawa, Yoshio

AU - Iwasaki, Yusuke

AU - Kawasaki, Masato

AU - Kikuchi, Atsushi

AU - Kondo, Takumi

AU - Ozaki, Tatsuhisa

AU - Seo, Masahiro

AU - Sato, Yoshihiro

AU - Ikeda, Iyo

AU - Fukuhara, Eiji

AU - Abe, Makoto

AU - Nakamura, Jun

AU - Fukunami, Masatake

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Background: The sympathetic nervous system provides an important trigger for major arrhythmic events through regional heterogeneity of sympathetic activity, which could be evaluated by SPECT imaging as the regional MIBG washout rate (WR). There is little information available on the prognostic value of regional WR in SPECT imaging for the prediction of sudden cardiac death (SCD) in patients with chronic heart failure (CHF). Methods: We studied 73 CHF outpatients with LVEF < 40%. At study entry, the regional WR was measured in 17 segments on the polar map. We defined abnormal regional WR as both the regional WR range (maximum − minimum regional WR) and maximum regional WR > mean value + 2SD obtained in 15 normal controls. Results: During a mean follow-up of 7.5 ± 4.1 years, 15 of 73 patients had SCD. The abnormal regional WR and abnormal global WR on planar images were significantly and independently associated with SCD. Patients with both the abnormal regional WR and global WR had a significantly higher risk of SCD than those with none of these criteria. Conclusions: The analysis of regional MIBG WR on SPECT imaging provides additional prognostic value to global WR on planar images for SCD prediction in CHF patients.

AB - Background: The sympathetic nervous system provides an important trigger for major arrhythmic events through regional heterogeneity of sympathetic activity, which could be evaluated by SPECT imaging as the regional MIBG washout rate (WR). There is little information available on the prognostic value of regional WR in SPECT imaging for the prediction of sudden cardiac death (SCD) in patients with chronic heart failure (CHF). Methods: We studied 73 CHF outpatients with LVEF < 40%. At study entry, the regional WR was measured in 17 segments on the polar map. We defined abnormal regional WR as both the regional WR range (maximum − minimum regional WR) and maximum regional WR > mean value + 2SD obtained in 15 normal controls. Results: During a mean follow-up of 7.5 ± 4.1 years, 15 of 73 patients had SCD. The abnormal regional WR and abnormal global WR on planar images were significantly and independently associated with SCD. Patients with both the abnormal regional WR and global WR had a significantly higher risk of SCD than those with none of these criteria. Conclusions: The analysis of regional MIBG WR on SPECT imaging provides additional prognostic value to global WR on planar images for SCD prediction in CHF patients.

KW - MIBG imaging

KW - SPECT

KW - heart failure

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UR - http://www.scopus.com/inward/citedby.url?scp=85019218680&partnerID=8YFLogxK

U2 - 10.1007/s12350-017-0913-0

DO - 10.1007/s12350-017-0913-0

M3 - Article

C2 - 28500540

AN - SCOPUS:85019218680

SN - 1071-3581

VL - 26

SP - 109

EP - 117

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

IS - 1

ER -

Prediction of sudden cardiac death in patients with chronic heart failure by regional washout rate in cardiac MIBG SPECT imaging

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