Prediction of the no-reflow phenomenon during percutaneous coronary intervention using coronary computed tomography angiography

Hiroto Harigaya, Sadako Motoyama, Masayoshi Sarai, Kaori Inoue, Tomonori Hara, Masanori Okumura, Hiroyuki Naruse, Junichi Ishii, Hitoshi Hishida, Yukio Ozaki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Coronary computed tomography angiography (CTA) can assess plaque characteristics and plaque size noninvasively. The purpose of this study was to investigate whether coronary CTA before percutaneous coronary intervention (PCI) can predict the no-reflow phenomenon during PCI. Seventy-eight patients [acute coronary syndrome (ACS) = 43, stable angina pectoris (SAP) = 35, male/female = 72/6, age: 65 ± 10 years] who underwent 16- or 64-slice CTA in the 4 weeks before PCI were enrolled. The low attenuation plaque size on CTA was compared between patients with (NR+) and without the no-reflow phenomenon (NR-). No-reflow phenomenon was observed in 11 patients, including 10 patients with ACS and 1 patient with SAP. Low attenuation plaque was detected in 9 (82%) NR(+) lesions and 35 (52%) NR(-) lesions. The length of low attenuation plaque was significantly longer in NR(+) than in NR(-) patients (9.0 ± 6.5 vs. 1.6 ± 2.7 mm, p<0.0001). On step-wise regression analysis, ACS (p = 0.036, 95% CI = 0.009'0.258) and the presence of low attenuation plaque with a length >4.7 mm (p<0.001, 95% CI = 0.447'0.778) were significant independent predictors of NR(-) no-reflow phenomenon. Low attenuation plaque with lesion length of >4.7 mm on coronary CTA and ACS were the significant predictors for the no-reflow phenomenon during PCI. Coronary CTA assessment before PCI would be useful to predict coronary events during PCI in advance.

Original languageEnglish
Pages (from-to)363-369
Number of pages7
JournalHeart and Vessels
Volume26
Issue number4
DOIs
Publication statusPublished - 01-07-2011

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No-Reflow Phenomenon
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Stable Angina
Computed Tomography Angiography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Harigaya, Hiroto ; Motoyama, Sadako ; Sarai, Masayoshi ; Inoue, Kaori ; Hara, Tomonori ; Okumura, Masanori ; Naruse, Hiroyuki ; Ishii, Junichi ; Hishida, Hitoshi ; Ozaki, Yukio. / Prediction of the no-reflow phenomenon during percutaneous coronary intervention using coronary computed tomography angiography. In: Heart and Vessels. 2011 ; Vol. 26, No. 4. pp. 363-369.
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abstract = "Coronary computed tomography angiography (CTA) can assess plaque characteristics and plaque size noninvasively. The purpose of this study was to investigate whether coronary CTA before percutaneous coronary intervention (PCI) can predict the no-reflow phenomenon during PCI. Seventy-eight patients [acute coronary syndrome (ACS) = 43, stable angina pectoris (SAP) = 35, male/female = 72/6, age: 65 ± 10 years] who underwent 16- or 64-slice CTA in the 4 weeks before PCI were enrolled. The low attenuation plaque size on CTA was compared between patients with (NR+) and without the no-reflow phenomenon (NR-). No-reflow phenomenon was observed in 11 patients, including 10 patients with ACS and 1 patient with SAP. Low attenuation plaque was detected in 9 (82{\%}) NR(+) lesions and 35 (52{\%}) NR(-) lesions. The length of low attenuation plaque was significantly longer in NR(+) than in NR(-) patients (9.0 ± 6.5 vs. 1.6 ± 2.7 mm, p<0.0001). On step-wise regression analysis, ACS (p = 0.036, 95{\%} CI = 0.009'0.258) and the presence of low attenuation plaque with a length >4.7 mm (p<0.001, 95{\%} CI = 0.447'0.778) were significant independent predictors of NR(-) no-reflow phenomenon. Low attenuation plaque with lesion length of >4.7 mm on coronary CTA and ACS were the significant predictors for the no-reflow phenomenon during PCI. Coronary CTA assessment before PCI would be useful to predict coronary events during PCI in advance.",
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Prediction of the no-reflow phenomenon during percutaneous coronary intervention using coronary computed tomography angiography. / Harigaya, Hiroto; Motoyama, Sadako; Sarai, Masayoshi; Inoue, Kaori; Hara, Tomonori; Okumura, Masanori; Naruse, Hiroyuki; Ishii, Junichi; Hishida, Hitoshi; Ozaki, Yukio.

In: Heart and Vessels, Vol. 26, No. 4, 01.07.2011, p. 363-369.

Research output: Contribution to journalArticle

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T1 - Prediction of the no-reflow phenomenon during percutaneous coronary intervention using coronary computed tomography angiography

AU - Harigaya, Hiroto

AU - Motoyama, Sadako

AU - Sarai, Masayoshi

AU - Inoue, Kaori

AU - Hara, Tomonori

AU - Okumura, Masanori

AU - Naruse, Hiroyuki

AU - Ishii, Junichi

AU - Hishida, Hitoshi

AU - Ozaki, Yukio

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Y1 - 2011/7/1

N2 - Coronary computed tomography angiography (CTA) can assess plaque characteristics and plaque size noninvasively. The purpose of this study was to investigate whether coronary CTA before percutaneous coronary intervention (PCI) can predict the no-reflow phenomenon during PCI. Seventy-eight patients [acute coronary syndrome (ACS) = 43, stable angina pectoris (SAP) = 35, male/female = 72/6, age: 65 ± 10 years] who underwent 16- or 64-slice CTA in the 4 weeks before PCI were enrolled. The low attenuation plaque size on CTA was compared between patients with (NR+) and without the no-reflow phenomenon (NR-). No-reflow phenomenon was observed in 11 patients, including 10 patients with ACS and 1 patient with SAP. Low attenuation plaque was detected in 9 (82%) NR(+) lesions and 35 (52%) NR(-) lesions. The length of low attenuation plaque was significantly longer in NR(+) than in NR(-) patients (9.0 ± 6.5 vs. 1.6 ± 2.7 mm, p<0.0001). On step-wise regression analysis, ACS (p = 0.036, 95% CI = 0.009'0.258) and the presence of low attenuation plaque with a length >4.7 mm (p<0.001, 95% CI = 0.447'0.778) were significant independent predictors of NR(-) no-reflow phenomenon. Low attenuation plaque with lesion length of >4.7 mm on coronary CTA and ACS were the significant predictors for the no-reflow phenomenon during PCI. Coronary CTA assessment before PCI would be useful to predict coronary events during PCI in advance.

AB - Coronary computed tomography angiography (CTA) can assess plaque characteristics and plaque size noninvasively. The purpose of this study was to investigate whether coronary CTA before percutaneous coronary intervention (PCI) can predict the no-reflow phenomenon during PCI. Seventy-eight patients [acute coronary syndrome (ACS) = 43, stable angina pectoris (SAP) = 35, male/female = 72/6, age: 65 ± 10 years] who underwent 16- or 64-slice CTA in the 4 weeks before PCI were enrolled. The low attenuation plaque size on CTA was compared between patients with (NR+) and without the no-reflow phenomenon (NR-). No-reflow phenomenon was observed in 11 patients, including 10 patients with ACS and 1 patient with SAP. Low attenuation plaque was detected in 9 (82%) NR(+) lesions and 35 (52%) NR(-) lesions. The length of low attenuation plaque was significantly longer in NR(+) than in NR(-) patients (9.0 ± 6.5 vs. 1.6 ± 2.7 mm, p<0.0001). On step-wise regression analysis, ACS (p = 0.036, 95% CI = 0.009'0.258) and the presence of low attenuation plaque with a length >4.7 mm (p<0.001, 95% CI = 0.447'0.778) were significant independent predictors of NR(-) no-reflow phenomenon. Low attenuation plaque with lesion length of >4.7 mm on coronary CTA and ACS were the significant predictors for the no-reflow phenomenon during PCI. Coronary CTA assessment before PCI would be useful to predict coronary events during PCI in advance.

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