TY - JOUR
T1 - Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms
T2 - JSH-MPN-R18 subanalysis
AU - Nagaharu, Keiki
AU - Ohya, Eiko
AU - Edahiro, Yoko
AU - Hashimoto, Yoshinori
AU - Ito, Tomoki
AU - Gotoh, Akihiko
AU - Nakamae, Mika
AU - Kimura, Fumihiko
AU - Koike, Michiaki
AU - Kirito, Keita
AU - Wada, Hideho
AU - Usuki, Kensuke
AU - Tanaka, Takayuki
AU - Mori, Takehiko
AU - Wakita, Satoshi
AU - Saito, Toshiki I.
AU - Saito, Akiko M.
AU - Shimoda, Kazuya
AU - Kurokawa, Toshiro
AU - Tomita, Akihiro
AU - Kiyoi, Hitoshi
AU - Akashi, Koichi
AU - Matsumura, Itaru
AU - Takenaka, Katsuto
AU - Komatsu, Norio
AU - Ohishi, Kohshi
AU - Tawara, Isao
AU - Sugimoto, Yuka
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. corrected publication 2024.
PY - 2024/9
Y1 - 2024/9
N2 - Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive parameters for thrombosis among complete blood count (CBC) results. Among the patients enrolled in JSH-MPN-R18, those with essential thrombocythemia (ET; n = 1152) and polycythemia vera (PV; n = 456) were investigated. We analyzed and compared CBC parameters between patients with and those without any thrombotic events using Welch’s T-test. Statistical analyses were performed using the R statistical software. Thrombotic events were observed in 74 patients with ET. In multivariate analysis, only the neutrophil ratio was slightly but significantly higher for ET patients with thrombosis than for those without (p < 0.05). Of note, the absolute neutrophil count (aNeu) was considered a useful predictive tool for thrombosis among patients classified as low-risk according to the revised International Prognostic Score of Thrombosis for Essential Thrombocythemia. Among PV patients, those with thrombosis showed significantly higher hematocrit and aNeu than did those without thrombosis. As a thrombosis-associated factor, the neutrophil ratio was slightly but significantly elevated in patients with ET. This myeloid skew might reflect a higher value of JAK2 V617F allelic frequency in patients with ET with thrombosis; this was not clarified in JSH-MPN-R18. Further accumulation of evidence, including genetic information for JAK2 and other passenger mutations, is warranted.
AB - Thrombosis in myeloproliferative neoplasms (MPNs) is an important clinical problem, and risk-stratified management is essential. To identify the clinical characteristics of thrombosis in patients with MPNs, a nationwide multi-institutional retrospective analysis (JSH-MPN-R18) was conducted. The aim of the present study was to perform a sub-analysis of JSH-MPN-R18 findings to clarify the predictive parameters for thrombosis among complete blood count (CBC) results. Among the patients enrolled in JSH-MPN-R18, those with essential thrombocythemia (ET; n = 1152) and polycythemia vera (PV; n = 456) were investigated. We analyzed and compared CBC parameters between patients with and those without any thrombotic events using Welch’s T-test. Statistical analyses were performed using the R statistical software. Thrombotic events were observed in 74 patients with ET. In multivariate analysis, only the neutrophil ratio was slightly but significantly higher for ET patients with thrombosis than for those without (p < 0.05). Of note, the absolute neutrophil count (aNeu) was considered a useful predictive tool for thrombosis among patients classified as low-risk according to the revised International Prognostic Score of Thrombosis for Essential Thrombocythemia. Among PV patients, those with thrombosis showed significantly higher hematocrit and aNeu than did those without thrombosis. As a thrombosis-associated factor, the neutrophil ratio was slightly but significantly elevated in patients with ET. This myeloid skew might reflect a higher value of JAK2 V617F allelic frequency in patients with ET with thrombosis; this was not clarified in JSH-MPN-R18. Further accumulation of evidence, including genetic information for JAK2 and other passenger mutations, is warranted.
KW - Essential thrombosis
KW - JAK2 mutation
KW - Polycythemia vera
KW - Thrombosis
UR - https://www.scopus.com/pages/publications/85199251716
UR - https://www.scopus.com/pages/publications/85199251716#tab=citedBy
U2 - 10.1007/s00277-024-05898-3
DO - 10.1007/s00277-024-05898-3
M3 - Article
C2 - 39037588
AN - SCOPUS:85199251716
SN - 0939-5555
VL - 103
SP - 3535
EP - 3541
JO - Annals of Hematology
JF - Annals of Hematology
IS - 9
ER -