Predictive value of acetylcholine stimulation testing for oligohidrosis caused by zonisamide

Akihisa Okumura, Naoko Ishihara, Toru Kato, Fumio Hayakawa, Kuniyoshi Kuno, Kazuyoshi Watanabe

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


We studied 16 patients for whom zonisamide was newly prescribed. Acetylcholine stimulation testing was performed about 1 month after zonisamide was initiated. Oligohidrosis occurred in none of the four with a normal response and in four of the 12 with a decreased response. Acetylcholine stimulation testing predicted oligohidrosis with a sensitivity of 1 and a false-positive rate of 0.67. The acetylcholine stimulation test was sensitive in detecting oligohidrosis caused by zonisamide, although the false-positive rate was high. (C) 2000 by Elsevier Science Inc.

Original languageEnglish
Pages (from-to)59-61
Number of pages3
JournalPediatric Neurology
Issue number1
Publication statusPublished - 07-2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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