Expression patterns for the two isoforms of α1(II) mRNA in various cartilaginous tissues were examined using newly isolated cDNA clones encoding rabbit type II procollagen amino- and carboxy-terminal propeptide regions. In nonchondrogenic nucleus pulposus, the switching of the mRNA from the long form to the short form was accompanied by disc maturation after birth. Interestingly, the short transcript was also expressed preferentially in human chordoma tissues as aberrant chordal vestiges. These results suggest an abundance of the differentiated chondrocyte-like phenotype in the heterogeneous notochordal remnants.
|Number of pages||6|
|Journal||Biochimica et Biophysica Acta - Gene Structure and Expression|
|Publication status||Published - 28-03-1997|
All Science Journal Classification (ASJC) codes
- Structural Biology