Preliminary genome-wide association study of bipolar disorder in the Japanese population

Eiji Hattori, Tomoko Toyota, Yuichi Ishitsuka, Yoshimi Iwayama, Kazuo Yamada, Hiroshi Ujike, Yukitaka Morita, Masafumi Kodama, Kenji Nakata, Yoshio Minabe, Kazuhiko Nakamura, Yasuhide Iwata, Nori Takei, Norio Mori, Hiroshi Naitoh, Yoshio Yamanouchi, Nakao Iwata, Norio Ozaki, Tadafumi Kato, Toru NishikawaAtsushi Kashiwa, Mika Suzuki, Kunihiko Shioe, Manabu Shinohara, Masami Hirano, Shinichiro Nanko, Akihisa Akahane, Mikako Ueno, Naoshi Kaneko, Yuichiro Watanabe, Toshiyuki Someya, Kenji Hashimoto, Masaomi Iyo, Masanari Itokawa, Makoto Arai, Masahiro Nankai, Toshiya Inada, Sumiko Yoshida, Hiroshi Kunugi, Michiko Nakamura, Yoshimi Iijima, Yuji Okazaki, Teruhiko Higuchi, Takeo Yoshikawa

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Recent progress in genotyping technology and the development of public databases has enabled large-scale genome-wide association tests with diseases. We performed a two-stage genomewide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder and 107 controls, and selected markers that were nominally significant (P<0.01) in at least one of the three models (1,577 markers in total). In the follow-up stage, we analyzed these markers using an Illumina platform (1,526 markers; 51 markers were not designable for the platform) and an independent sample set, which consisted of 395 cases (bipolar I+II) and 409 controls. We also assessed the population stratification of current samples using principal components analysis. After the two-stage analysis, 89 markers remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. However, none of these were significant after correction for multiple-testing by false discovery rates. Sample stratification was virtually negligible. Collectively, this is the firstGWAS of BD in the Japanese population. But given the small sample size and the limited genomic coverage, these results should be taken as preliminary.

Original languageEnglish
Pages (from-to)1110-1117
Number of pages8
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume150
Issue number8
DOIs
Publication statusPublished - 05-12-2009

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Genome-Wide Association Study
Bipolar Disorder
Population
Principal Component Analysis
Sample Size
Alleles
Genome
Databases
Technology

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Hattori, Eiji ; Toyota, Tomoko ; Ishitsuka, Yuichi ; Iwayama, Yoshimi ; Yamada, Kazuo ; Ujike, Hiroshi ; Morita, Yukitaka ; Kodama, Masafumi ; Nakata, Kenji ; Minabe, Yoshio ; Nakamura, Kazuhiko ; Iwata, Yasuhide ; Takei, Nori ; Mori, Norio ; Naitoh, Hiroshi ; Yamanouchi, Yoshio ; Iwata, Nakao ; Ozaki, Norio ; Kato, Tadafumi ; Nishikawa, Toru ; Kashiwa, Atsushi ; Suzuki, Mika ; Shioe, Kunihiko ; Shinohara, Manabu ; Hirano, Masami ; Nanko, Shinichiro ; Akahane, Akihisa ; Ueno, Mikako ; Kaneko, Naoshi ; Watanabe, Yuichiro ; Someya, Toshiyuki ; Hashimoto, Kenji ; Iyo, Masaomi ; Itokawa, Masanari ; Arai, Makoto ; Nankai, Masahiro ; Inada, Toshiya ; Yoshida, Sumiko ; Kunugi, Hiroshi ; Nakamura, Michiko ; Iijima, Yoshimi ; Okazaki, Yuji ; Higuchi, Teruhiko ; Yoshikawa, Takeo. / Preliminary genome-wide association study of bipolar disorder in the Japanese population. In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2009 ; Vol. 150, No. 8. pp. 1110-1117.
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abstract = "Recent progress in genotyping technology and the development of public databases has enabled large-scale genome-wide association tests with diseases. We performed a two-stage genomewide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder and 107 controls, and selected markers that were nominally significant (P<0.01) in at least one of the three models (1,577 markers in total). In the follow-up stage, we analyzed these markers using an Illumina platform (1,526 markers; 51 markers were not designable for the platform) and an independent sample set, which consisted of 395 cases (bipolar I+II) and 409 controls. We also assessed the population stratification of current samples using principal components analysis. After the two-stage analysis, 89 markers remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. However, none of these were significant after correction for multiple-testing by false discovery rates. Sample stratification was virtually negligible. Collectively, this is the firstGWAS of BD in the Japanese population. But given the small sample size and the limited genomic coverage, these results should be taken as preliminary.",
author = "Eiji Hattori and Tomoko Toyota and Yuichi Ishitsuka and Yoshimi Iwayama and Kazuo Yamada and Hiroshi Ujike and Yukitaka Morita and Masafumi Kodama and Kenji Nakata and Yoshio Minabe and Kazuhiko Nakamura and Yasuhide Iwata and Nori Takei and Norio Mori and Hiroshi Naitoh and Yoshio Yamanouchi and Nakao Iwata and Norio Ozaki and Tadafumi Kato and Toru Nishikawa and Atsushi Kashiwa and Mika Suzuki and Kunihiko Shioe and Manabu Shinohara and Masami Hirano and Shinichiro Nanko and Akihisa Akahane and Mikako Ueno and Naoshi Kaneko and Yuichiro Watanabe and Toshiyuki Someya and Kenji Hashimoto and Masaomi Iyo and Masanari Itokawa and Makoto Arai and Masahiro Nankai and Toshiya Inada and Sumiko Yoshida and Hiroshi Kunugi and Michiko Nakamura and Yoshimi Iijima and Yuji Okazaki and Teruhiko Higuchi and Takeo Yoshikawa",
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Hattori, E, Toyota, T, Ishitsuka, Y, Iwayama, Y, Yamada, K, Ujike, H, Morita, Y, Kodama, M, Nakata, K, Minabe, Y, Nakamura, K, Iwata, Y, Takei, N, Mori, N, Naitoh, H, Yamanouchi, Y, Iwata, N, Ozaki, N, Kato, T, Nishikawa, T, Kashiwa, A, Suzuki, M, Shioe, K, Shinohara, M, Hirano, M, Nanko, S, Akahane, A, Ueno, M, Kaneko, N, Watanabe, Y, Someya, T, Hashimoto, K, Iyo, M, Itokawa, M, Arai, M, Nankai, M, Inada, T, Yoshida, S, Kunugi, H, Nakamura, M, Iijima, Y, Okazaki, Y, Higuchi, T & Yoshikawa, T 2009, 'Preliminary genome-wide association study of bipolar disorder in the Japanese population', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 150, no. 8, pp. 1110-1117. https://doi.org/10.1002/ajmg.b.30941

Preliminary genome-wide association study of bipolar disorder in the Japanese population. / Hattori, Eiji; Toyota, Tomoko; Ishitsuka, Yuichi; Iwayama, Yoshimi; Yamada, Kazuo; Ujike, Hiroshi; Morita, Yukitaka; Kodama, Masafumi; Nakata, Kenji; Minabe, Yoshio; Nakamura, Kazuhiko; Iwata, Yasuhide; Takei, Nori; Mori, Norio; Naitoh, Hiroshi; Yamanouchi, Yoshio; Iwata, Nakao; Ozaki, Norio; Kato, Tadafumi; Nishikawa, Toru; Kashiwa, Atsushi; Suzuki, Mika; Shioe, Kunihiko; Shinohara, Manabu; Hirano, Masami; Nanko, Shinichiro; Akahane, Akihisa; Ueno, Mikako; Kaneko, Naoshi; Watanabe, Yuichiro; Someya, Toshiyuki; Hashimoto, Kenji; Iyo, Masaomi; Itokawa, Masanari; Arai, Makoto; Nankai, Masahiro; Inada, Toshiya; Yoshida, Sumiko; Kunugi, Hiroshi; Nakamura, Michiko; Iijima, Yoshimi; Okazaki, Yuji; Higuchi, Teruhiko; Yoshikawa, Takeo.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 150, No. 8, 05.12.2009, p. 1110-1117.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Preliminary genome-wide association study of bipolar disorder in the Japanese population

AU - Hattori, Eiji

AU - Toyota, Tomoko

AU - Ishitsuka, Yuichi

AU - Iwayama, Yoshimi

AU - Yamada, Kazuo

AU - Ujike, Hiroshi

AU - Morita, Yukitaka

AU - Kodama, Masafumi

AU - Nakata, Kenji

AU - Minabe, Yoshio

AU - Nakamura, Kazuhiko

AU - Iwata, Yasuhide

AU - Takei, Nori

AU - Mori, Norio

AU - Naitoh, Hiroshi

AU - Yamanouchi, Yoshio

AU - Iwata, Nakao

AU - Ozaki, Norio

AU - Kato, Tadafumi

AU - Nishikawa, Toru

AU - Kashiwa, Atsushi

AU - Suzuki, Mika

AU - Shioe, Kunihiko

AU - Shinohara, Manabu

AU - Hirano, Masami

AU - Nanko, Shinichiro

AU - Akahane, Akihisa

AU - Ueno, Mikako

AU - Kaneko, Naoshi

AU - Watanabe, Yuichiro

AU - Someya, Toshiyuki

AU - Hashimoto, Kenji

AU - Iyo, Masaomi

AU - Itokawa, Masanari

AU - Arai, Makoto

AU - Nankai, Masahiro

AU - Inada, Toshiya

AU - Yoshida, Sumiko

AU - Kunugi, Hiroshi

AU - Nakamura, Michiko

AU - Iijima, Yoshimi

AU - Okazaki, Yuji

AU - Higuchi, Teruhiko

AU - Yoshikawa, Takeo

PY - 2009/12/5

Y1 - 2009/12/5

N2 - Recent progress in genotyping technology and the development of public databases has enabled large-scale genome-wide association tests with diseases. We performed a two-stage genomewide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder and 107 controls, and selected markers that were nominally significant (P<0.01) in at least one of the three models (1,577 markers in total). In the follow-up stage, we analyzed these markers using an Illumina platform (1,526 markers; 51 markers were not designable for the platform) and an independent sample set, which consisted of 395 cases (bipolar I+II) and 409 controls. We also assessed the population stratification of current samples using principal components analysis. After the two-stage analysis, 89 markers remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. However, none of these were significant after correction for multiple-testing by false discovery rates. Sample stratification was virtually negligible. Collectively, this is the firstGWAS of BD in the Japanese population. But given the small sample size and the limited genomic coverage, these results should be taken as preliminary.

AB - Recent progress in genotyping technology and the development of public databases has enabled large-scale genome-wide association tests with diseases. We performed a two-stage genomewide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder and 107 controls, and selected markers that were nominally significant (P<0.01) in at least one of the three models (1,577 markers in total). In the follow-up stage, we analyzed these markers using an Illumina platform (1,526 markers; 51 markers were not designable for the platform) and an independent sample set, which consisted of 395 cases (bipolar I+II) and 409 controls. We also assessed the population stratification of current samples using principal components analysis. After the two-stage analysis, 89 markers remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. However, none of these were significant after correction for multiple-testing by false discovery rates. Sample stratification was virtually negligible. Collectively, this is the firstGWAS of BD in the Japanese population. But given the small sample size and the limited genomic coverage, these results should be taken as preliminary.

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