Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate

a cross-sectional study

Xiaofang Jia, Yukiko Harada, Masahiro Tagawa, Hisao Naito, Yumi Hayashi, Husna Yetti, Masashi Kato, Seiko Sasaki, Atsuko Araki, Chihiro Miyashita, Tamiko Ikeno, Reiko Kishi, Tamie Nakajima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: The hypolipidemic effects of di(2-ethylhexyl)phthalate (DEHP) exposure in humans have not been investigated. And the influences of maternal prenatal DEHP exposure on birth outcomes are not well-known. We aimed to estimate prenatal DEHP exposure in maternal blood, and evaluate its relationships to maternal blood triglyceride (TG) and fatty acid (FA) levels and to birth outcomes. Methods: We studied 318 mother–newborn pairs residing in Sapporo, Japan. Blood was taken one time during pregnancy for each mother. Maternal and infant characteristics were obtained from medical records and questionnaire survey. We measured DEHP metabolite, mono(2-ethylhexyl) phthalate (MEHP), along with TG and 9 FAs using maternal blood, and analyzed associations of MEHP level with maternal blood TG/FA levels and infant birth dimensions. Results: Maternal blood TG and palmitoleic/oleic acid levels were higher, but stearic/docosahexaenoic acids and MEHP were lower during late pregnancy. Maternal blood MEHP levels inversely correlated with TG and palmitic/palmitoleic/oleic/linoleic/α-linolenic acids. After adjustment for confounders, we found that a tenfold increase in blood MEHP levels correlated with a decrease in TG of 25.1 mg/dl [95 % confidence interval (CI) 4.8–45.3 mg/dl], and similar relations in palmitic (β = −581.8; 95 % CI −906.5, −257.0), oleic (β = −304.2; 95 % CI −518.0, −90.5), linoleic (β = −348.6; 95 % CI −510.6, −186.6), and α-linolenic (β = −6.3; 95 % CI −9.5, −3.0) acids. However, we observed no correlations between maternal blood MEHP levels and infant birth weight, length, chest circumference, or head circumference. Conclusions: Ambient DEHP exposure during pregnancy inversely correlated with maternal blood TG and 4 FA levels, but not birth outcomes.

Original languageEnglish
Pages (from-to)168-178
Number of pages11
JournalEnvironmental Health and Preventive Medicine
Volume20
Issue number3
DOIs
Publication statusPublished - 18-05-2015

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Triglycerides
Fatty Acids
Cross-Sectional Studies
Mothers
Confidence Intervals
Parturition
Pregnancy
Linolenic Acids
phthalic acid
Stearic Acids
Linoleic Acids
Maternal Exposure
Oleic Acid
Birth Weight
Medical Records
mono-(2-ethylhexyl)phthalate
Japan
Thorax
Head
Acids

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Jia, Xiaofang ; Harada, Yukiko ; Tagawa, Masahiro ; Naito, Hisao ; Hayashi, Yumi ; Yetti, Husna ; Kato, Masashi ; Sasaki, Seiko ; Araki, Atsuko ; Miyashita, Chihiro ; Ikeno, Tamiko ; Kishi, Reiko ; Nakajima, Tamie. / Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate : a cross-sectional study. In: Environmental Health and Preventive Medicine. 2015 ; Vol. 20, No. 3. pp. 168-178.
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abstract = "Objectives: The hypolipidemic effects of di(2-ethylhexyl)phthalate (DEHP) exposure in humans have not been investigated. And the influences of maternal prenatal DEHP exposure on birth outcomes are not well-known. We aimed to estimate prenatal DEHP exposure in maternal blood, and evaluate its relationships to maternal blood triglyceride (TG) and fatty acid (FA) levels and to birth outcomes. Methods: We studied 318 mother–newborn pairs residing in Sapporo, Japan. Blood was taken one time during pregnancy for each mother. Maternal and infant characteristics were obtained from medical records and questionnaire survey. We measured DEHP metabolite, mono(2-ethylhexyl) phthalate (MEHP), along with TG and 9 FAs using maternal blood, and analyzed associations of MEHP level with maternal blood TG/FA levels and infant birth dimensions. Results: Maternal blood TG and palmitoleic/oleic acid levels were higher, but stearic/docosahexaenoic acids and MEHP were lower during late pregnancy. Maternal blood MEHP levels inversely correlated with TG and palmitic/palmitoleic/oleic/linoleic/α-linolenic acids. After adjustment for confounders, we found that a tenfold increase in blood MEHP levels correlated with a decrease in TG of 25.1 mg/dl [95 {\%} confidence interval (CI) 4.8–45.3 mg/dl], and similar relations in palmitic (β = −581.8; 95 {\%} CI −906.5, −257.0), oleic (β = −304.2; 95 {\%} CI −518.0, −90.5), linoleic (β = −348.6; 95 {\%} CI −510.6, −186.6), and α-linolenic (β = −6.3; 95 {\%} CI −9.5, −3.0) acids. However, we observed no correlations between maternal blood MEHP levels and infant birth weight, length, chest circumference, or head circumference. Conclusions: Ambient DEHP exposure during pregnancy inversely correlated with maternal blood TG and 4 FA levels, but not birth outcomes.",
author = "Xiaofang Jia and Yukiko Harada and Masahiro Tagawa and Hisao Naito and Yumi Hayashi and Husna Yetti and Masashi Kato and Seiko Sasaki and Atsuko Araki and Chihiro Miyashita and Tamiko Ikeno and Reiko Kishi and Tamie Nakajima",
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Jia, X, Harada, Y, Tagawa, M, Naito, H, Hayashi, Y, Yetti, H, Kato, M, Sasaki, S, Araki, A, Miyashita, C, Ikeno, T, Kishi, R & Nakajima, T 2015, 'Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study', Environmental Health and Preventive Medicine, vol. 20, no. 3, pp. 168-178. https://doi.org/10.1007/s12199-014-0440-4

Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate : a cross-sectional study. / Jia, Xiaofang; Harada, Yukiko; Tagawa, Masahiro; Naito, Hisao; Hayashi, Yumi; Yetti, Husna; Kato, Masashi; Sasaki, Seiko; Araki, Atsuko; Miyashita, Chihiro; Ikeno, Tamiko; Kishi, Reiko; Nakajima, Tamie.

In: Environmental Health and Preventive Medicine, Vol. 20, No. 3, 18.05.2015, p. 168-178.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate

T2 - a cross-sectional study

AU - Jia, Xiaofang

AU - Harada, Yukiko

AU - Tagawa, Masahiro

AU - Naito, Hisao

AU - Hayashi, Yumi

AU - Yetti, Husna

AU - Kato, Masashi

AU - Sasaki, Seiko

AU - Araki, Atsuko

AU - Miyashita, Chihiro

AU - Ikeno, Tamiko

AU - Kishi, Reiko

AU - Nakajima, Tamie

PY - 2015/5/18

Y1 - 2015/5/18

N2 - Objectives: The hypolipidemic effects of di(2-ethylhexyl)phthalate (DEHP) exposure in humans have not been investigated. And the influences of maternal prenatal DEHP exposure on birth outcomes are not well-known. We aimed to estimate prenatal DEHP exposure in maternal blood, and evaluate its relationships to maternal blood triglyceride (TG) and fatty acid (FA) levels and to birth outcomes. Methods: We studied 318 mother–newborn pairs residing in Sapporo, Japan. Blood was taken one time during pregnancy for each mother. Maternal and infant characteristics were obtained from medical records and questionnaire survey. We measured DEHP metabolite, mono(2-ethylhexyl) phthalate (MEHP), along with TG and 9 FAs using maternal blood, and analyzed associations of MEHP level with maternal blood TG/FA levels and infant birth dimensions. Results: Maternal blood TG and palmitoleic/oleic acid levels were higher, but stearic/docosahexaenoic acids and MEHP were lower during late pregnancy. Maternal blood MEHP levels inversely correlated with TG and palmitic/palmitoleic/oleic/linoleic/α-linolenic acids. After adjustment for confounders, we found that a tenfold increase in blood MEHP levels correlated with a decrease in TG of 25.1 mg/dl [95 % confidence interval (CI) 4.8–45.3 mg/dl], and similar relations in palmitic (β = −581.8; 95 % CI −906.5, −257.0), oleic (β = −304.2; 95 % CI −518.0, −90.5), linoleic (β = −348.6; 95 % CI −510.6, −186.6), and α-linolenic (β = −6.3; 95 % CI −9.5, −3.0) acids. However, we observed no correlations between maternal blood MEHP levels and infant birth weight, length, chest circumference, or head circumference. Conclusions: Ambient DEHP exposure during pregnancy inversely correlated with maternal blood TG and 4 FA levels, but not birth outcomes.

AB - Objectives: The hypolipidemic effects of di(2-ethylhexyl)phthalate (DEHP) exposure in humans have not been investigated. And the influences of maternal prenatal DEHP exposure on birth outcomes are not well-known. We aimed to estimate prenatal DEHP exposure in maternal blood, and evaluate its relationships to maternal blood triglyceride (TG) and fatty acid (FA) levels and to birth outcomes. Methods: We studied 318 mother–newborn pairs residing in Sapporo, Japan. Blood was taken one time during pregnancy for each mother. Maternal and infant characteristics were obtained from medical records and questionnaire survey. We measured DEHP metabolite, mono(2-ethylhexyl) phthalate (MEHP), along with TG and 9 FAs using maternal blood, and analyzed associations of MEHP level with maternal blood TG/FA levels and infant birth dimensions. Results: Maternal blood TG and palmitoleic/oleic acid levels were higher, but stearic/docosahexaenoic acids and MEHP were lower during late pregnancy. Maternal blood MEHP levels inversely correlated with TG and palmitic/palmitoleic/oleic/linoleic/α-linolenic acids. After adjustment for confounders, we found that a tenfold increase in blood MEHP levels correlated with a decrease in TG of 25.1 mg/dl [95 % confidence interval (CI) 4.8–45.3 mg/dl], and similar relations in palmitic (β = −581.8; 95 % CI −906.5, −257.0), oleic (β = −304.2; 95 % CI −518.0, −90.5), linoleic (β = −348.6; 95 % CI −510.6, −186.6), and α-linolenic (β = −6.3; 95 % CI −9.5, −3.0) acids. However, we observed no correlations between maternal blood MEHP levels and infant birth weight, length, chest circumference, or head circumference. Conclusions: Ambient DEHP exposure during pregnancy inversely correlated with maternal blood TG and 4 FA levels, but not birth outcomes.

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