Prenatal nicotine exposure and neuronal progenitor cells

Tursun Alkam, Toshitaka Nabeshima

Research output: Chapter in Book/Report/Conference proceedingChapter


During embryonic and early postnatal neurogenesis, the appearance of new signaling molecules on neuronal progenitor cells gives rise to a vast diversity of neuronal and glial cells. The newly differentiated neurons migrate to their final destinations to generate primary anatomical regions of the brain and begin to establish a lifelong functional communication route with fellow neurons. Any changes in neurogenesis during the prenatal period by any disruption of signaling pathways compromise the structures and functions of the brain for whole life. Nicotine, an ingredient in tobacco smoke, is thought to disturb the development of the fetal brain. Here, we discuss the impact of prenatal nicotine exposure on neurogenesis via certain subtypes of nicotinic acetylcholine receptors that are expressed on neuronal progenitor cells.

Original languageEnglish
Title of host publicationNeuroscience of Nicotine
Subtitle of host publicationMechanisms and Treatment
Number of pages8
ISBN (Electronic)9780128130353
ISBN (Print)9780128130360
Publication statusPublished - 01-01-2019


All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Alkam, T., & Nabeshima, T. (2019). Prenatal nicotine exposure and neuronal progenitor cells. In Neuroscience of Nicotine: Mechanisms and Treatment (pp. 41-48). Elsevier.