Prenatal vitamin A deficiency causes laryngeal malformation in rats

Ichiro Tateya, Tomoko Tateya, Rebecca Lynn Surles, Sherry Tanumihardjo, Diane M. Bless

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Objectives: Our previous research demonstrated that vitamin A might be related to vocal fold development. The purpose of this study was to determine whether vitamin A deficiency affects prenatal laryngeal development in rats. Methods: Two considerations were necessary in designing a study using a rat model: for embryonic survival, vitamin A is necessary through day 10 of gestation, and laryngeal formation occurs primarily after day 11. Thus, we created a rat model that developed vitamin A deficiency after embryonic day 11. Ten pregnant rats (5 vitamin A-deficient rats and 5 control rats) were studied. Embryos were collected at embryonic day 18.5 and analyzed histologically. Results: Eighteen percent of the vitamin A-deficient embryos were alive and demonstrated laryngotracheal cartilage malformation, incomplete separation of the glottis, and/or laryngoesophageal clefts. Conclusions: These results document the important role played by vitamin A in laryngeal development.

Original languageEnglish
Pages (from-to)785-792
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Issue number10
Publication statusPublished - 10-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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