Preneoplastic changes of stomach cancer - Mice, rats and Mongolian gerbils

Masae Tatematsu; Tetsuya Tsukamoto; Masami Yamamoto

doi:10.1293/tox.15.133

Preneoplastic changes of stomach cancer - Mice, rats and Mongolian gerbils

Masae Tatematsu, Tetsuya Tsukamoto, Masami Yamamoto

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Investigations of the clonal growth of gastric carcinomas clearly suggest that individual cancers are derived from single cells with multi-potential activities and that cellular differentiation of gastric cancer cells occurs secondarily. By mucin histochemistry, gastric cancer cells of each histological group could be clearly classified into a gastric type and an intestinal type. The present results suggest the independent induction of intestinal metaplasia and gastric cancers and the occurrence of change of phenotypic expression of tumor cells from the gastric type to the intestinal type during growth of tumors. The Pepsinogen altered pyloric gland (PAPG) detected immunohistochemically may be considered to be a preneoplastic change. Rare mutations of p53 and ras genes in rat and mouse stomach cancers were found and p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.

Original language	English
Pages (from-to)	133-136
Number of pages	4
Journal	Journal of Toxicologic Pathology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1293/tox.15.133
Publication status	Published - 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1293/tox.15.133

Cite this

@article{0f8e2dd9f69b4e6eac4b858cc031a809,

title = "Preneoplastic changes of stomach cancer - Mice, rats and Mongolian gerbils",

abstract = "Investigations of the clonal growth of gastric carcinomas clearly suggest that individual cancers are derived from single cells with multi-potential activities and that cellular differentiation of gastric cancer cells occurs secondarily. By mucin histochemistry, gastric cancer cells of each histological group could be clearly classified into a gastric type and an intestinal type. The present results suggest the independent induction of intestinal metaplasia and gastric cancers and the occurrence of change of phenotypic expression of tumor cells from the gastric type to the intestinal type during growth of tumors. The Pepsinogen altered pyloric gland (PAPG) detected immunohistochemically may be considered to be a preneoplastic change. Rare mutations of p53 and ras genes in rat and mouse stomach cancers were found and p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.",

author = "Masae Tatematsu and Tetsuya Tsukamoto and Masami Yamamoto",

year = "2002",

doi = "10.1293/tox.15.133",

language = "English",

volume = "15",

pages = "133--136",

journal = "Journal of Toxicologic Pathology",

issn = "0914-9198",

publisher = "Japanese Society of Toxicologic Pathology",

number = "2",

}

TY - JOUR

T1 - Preneoplastic changes of stomach cancer - Mice, rats and Mongolian gerbils

AU - Tatematsu, Masae

AU - Tsukamoto, Tetsuya

AU - Yamamoto, Masami

PY - 2002

Y1 - 2002

N2 - Investigations of the clonal growth of gastric carcinomas clearly suggest that individual cancers are derived from single cells with multi-potential activities and that cellular differentiation of gastric cancer cells occurs secondarily. By mucin histochemistry, gastric cancer cells of each histological group could be clearly classified into a gastric type and an intestinal type. The present results suggest the independent induction of intestinal metaplasia and gastric cancers and the occurrence of change of phenotypic expression of tumor cells from the gastric type to the intestinal type during growth of tumors. The Pepsinogen altered pyloric gland (PAPG) detected immunohistochemically may be considered to be a preneoplastic change. Rare mutations of p53 and ras genes in rat and mouse stomach cancers were found and p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.

AB - Investigations of the clonal growth of gastric carcinomas clearly suggest that individual cancers are derived from single cells with multi-potential activities and that cellular differentiation of gastric cancer cells occurs secondarily. By mucin histochemistry, gastric cancer cells of each histological group could be clearly classified into a gastric type and an intestinal type. The present results suggest the independent induction of intestinal metaplasia and gastric cancers and the occurrence of change of phenotypic expression of tumor cells from the gastric type to the intestinal type during growth of tumors. The Pepsinogen altered pyloric gland (PAPG) detected immunohistochemically may be considered to be a preneoplastic change. Rare mutations of p53 and ras genes in rat and mouse stomach cancers were found and p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.

UR - http://www.scopus.com/inward/record.url?scp=52649134489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52649134489&partnerID=8YFLogxK

U2 - 10.1293/tox.15.133

DO - 10.1293/tox.15.133

M3 - Review article

AN - SCOPUS:52649134489

SN - 0914-9198

VL - 15

SP - 133

EP - 136

JO - Journal of Toxicologic Pathology

JF - Journal of Toxicologic Pathology

IS - 2

ER -

Preneoplastic changes of stomach cancer - Mice, rats and Mongolian gerbils

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this