Preoperative albumin-bilirubin grade as a useful prognostic indicator in patients with pancreatic cancer

Takuki Yagyu, Hiroaki Saito, Teruhisa Sakamoto, Ei Uchinaka, Masaki Morimoto, Masataka Amisaki, Joji Watanabe, Naruo Tokuyasu, Soichiro Honjo, Keigo Ashida, Yoshiyuki Fujiwara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The albumin-bilirubin (ALBI) grade assesses the severity of liver dysfunction in patients with hepatocellular carcinoma. Herein we investigated the prognostic significance of the combination of the ALBI grade with serum carbohydrate antigen 19-9 (CA 19-9) concentration, the most frequently used tumor marker in pancreatic cancer (PC) in resected patients with PC. Materials and Methods: Included patients (n=100) had a histopathological diagnosis of pancreatic cancer and underwent pancreatectomy. Serum concentrations of albumin, bilirubin, and CA19-9 were measured within 5 days before surgery. Patients were divided into groups with high and low CA19-9 (cut-off ≥35 U/ml) and ALBI grade (2 and 3 vs. 1). Results: The 5-year overall survival (OS) rates of the ALBI High and ALBI Low groups were 21.6% and 35.3%, respectively (p=0.015). The 5-year OS rates of the CA19-9 High and CA19-9 Low groups were 22.2% and 41.5%, respectively (p=0.017). Patients were divided into groups A (ALBI High and CA19-9 High ), B (ALBI High and CA19-9 Low or ALBI Low and CA19-9 High ), and C (ALBI Low and CA19-9 Low ). The 5-year OS rates of groups A, B, and C were 13.8%, 31.0%, and 43.3%, respectively (p=0.0006). Multivariate analysis revealed that the ALBI grade combined with the CA19-9 concentration, served as an independent prognostic indicator. Conclusion: The combination of ALBI grade and CA19-9 concentration predicted the prognosis of patients with PC.

Original languageEnglish
Pages (from-to)1441-1446
Number of pages6
JournalAnticancer research
Volume39
Issue number3
DOIs
Publication statusPublished - 03-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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