TY - JOUR
T1 - Preoperative biliary drainage-related inflammation is associated with shorter survival in biliary tract cancer patients
AU - Kurahara, Hiroshi
AU - Maemura, Kosei
AU - Mataki, Yuko
AU - Sakoda, Masahiko
AU - Iino, Satoshi
AU - Kawasaki, Yota
AU - Arigami, Takaaki
AU - Uenosono, Yoshikazu
AU - Kijima, Yuko
AU - Shinchi, Hiroyuki
AU - Takao, Sonshin
AU - Natsugoe, Shoji
N1 - Publisher Copyright:
© 2016, Japan Society of Clinical Oncology.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background: An association between inflammation and patient prognosis has been reported in various types of cancer. The aim of this study was to evaluate the influence of preoperative biliary drainage-related inflammation in patients with biliary tract cancer. Methods: The clinical data of 97 patients who underwent surgery for extrahepatic bile duct cancer between February 2002 and September 2014 were analyzed, and the prognostic significance of tube-obstructive cholangitis after preoperative biliary drainage and pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) was evaluated. Results: Eighty-four (86.6 %) of the 97 patients underwent ERCP and preoperative biliary drainage. Tube-obstructive cholangitis occurred in 25 cases and post-ERCP pancreatitis in 8 cases. Collectively, 30 patients experienced preoperative biliary drainage-related inflammation consisting of tube-obstructive cholangitis and/or post-ERCP pancreatitis. Drainage-related inflammation was significant risk factor of postoperative complications (P = 0.006), and significant poor predictors of shorter progression-free survival (P = 0.003) and overall survival (OS; P = 0.006) after surgery. In multivariate analysis, drainage-related inflammation was an independent predictor of shorter OS (hazard ratio, 1.924; P = 0.037) after surgery. Conclusion: Preoperative biliary drainage-related inflammation was an independent prognostic factor for shorter OS in biliary tract cancer patients.
AB - Background: An association between inflammation and patient prognosis has been reported in various types of cancer. The aim of this study was to evaluate the influence of preoperative biliary drainage-related inflammation in patients with biliary tract cancer. Methods: The clinical data of 97 patients who underwent surgery for extrahepatic bile duct cancer between February 2002 and September 2014 were analyzed, and the prognostic significance of tube-obstructive cholangitis after preoperative biliary drainage and pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) was evaluated. Results: Eighty-four (86.6 %) of the 97 patients underwent ERCP and preoperative biliary drainage. Tube-obstructive cholangitis occurred in 25 cases and post-ERCP pancreatitis in 8 cases. Collectively, 30 patients experienced preoperative biliary drainage-related inflammation consisting of tube-obstructive cholangitis and/or post-ERCP pancreatitis. Drainage-related inflammation was significant risk factor of postoperative complications (P = 0.006), and significant poor predictors of shorter progression-free survival (P = 0.003) and overall survival (OS; P = 0.006) after surgery. In multivariate analysis, drainage-related inflammation was an independent predictor of shorter OS (hazard ratio, 1.924; P = 0.037) after surgery. Conclusion: Preoperative biliary drainage-related inflammation was an independent prognostic factor for shorter OS in biliary tract cancer patients.
UR - https://www.scopus.com/pages/publications/84958773138
UR - https://www.scopus.com/pages/publications/84958773138#tab=citedBy
U2 - 10.1007/s10147-016-0961-5
DO - 10.1007/s10147-016-0961-5
M3 - Article
C2 - 26894390
AN - SCOPUS:84958773138
SN - 1341-9625
VL - 21
SP - 934
EP - 939
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 5
ER -
