Preoperative Imatinib Therapy Followed by Laparoscopic Local Gastrectomy for a Giant Gastric Gastrointestinal Stromal Tumor-A Case Report

Michiko Inukai, Susumu Shibasaki, Kazumitsu Suzuki, Yasuhiro Tsuru, Kazuhiro Matsuo, Ai Goto, Kenichi Nakamura, Tsuyoshi Tanaka, Kenji Kikuchi, Koichi Suda, Kazuki Inaba, Ichiro Uyama

Research output: Contribution to journalArticlepeer-review

Abstract

A 55-year-old man complained of abdominal distention. Gastroscopy showed a submucosal tumor in the upper-third portion of the stomach, with a biopsy diagnosis of gastrointestinal stromal tumor(GIST). Because abdominal contrast- enhanced CT findings suspected the invasion of the tumor into the pancreatic tail, preoperative imatinib therapy was performed. After 2 weeks of treatment, the tumor had shrunk to 44% of its starting volume. Six months later, CT findings suggestive of the tumor invasion had disappeared. Therefore, the laparoscopic local resection of the stomach was performed. The postoperative course was uneventful. A pathological diagnosis was c-kit-positive GIST, with less than 5/50 HPF of mitotic counts. Imatinib was restarted 2 weeks after the operation. The patient is alive 8 months after the operation, with no obvious recurrence. Preoperative imatinib therapy can be a useful option for large GIST tumors.

Original languageEnglish
Pages (from-to)2062-2064
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume47
Issue number13
Publication statusPublished - 01-12-2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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