Preoperative lower body mass index correlates with poorer prognosis in patients undergoing curative laparoscopic surgery for colorectal cancer

Ryo Uratani; Yuji Toiyama; Tadanobu Shimura; Koichiro Mori; Hiroyuki Fujikawa; Jyunichiro Hiro; Masaki Ohi; Yasuhiro Inoue; Koji Tanaka; Toshimitsu Araki; Yasuhiko Mohri; Masato Kusunoki

Preoperative lower body mass index correlates with poorer prognosis in patients undergoing curative laparoscopic surgery for colorectal cancer

Ryo Uratani
, Yuji Toiyama
, Tadanobu Shimura
, Koichiro Mori
, Hiroyuki Fujikawa
, Jyunichiro Hiro
, Masaki Ohi
, Yasuhiro Inoue
, Koji Tanaka
, Toshimitsu Araki
, Yasuhiko Mohri
, Masato Kusunoki

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: The aim of this study was to investigate the correlations between clinicopathological findings, laboratory data and survival outcome in patients undergoing curative laparoscopic surgery for colorectal cancer (CRC). Patients and Methods: Clinicopathological findings and laboratory data, including tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) and systemic inflammatory response indicators, neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognosis score (mGPS), for 204 patients (tumor stage I-III) undergoing laparoscopic curative surgery for CRC were collected. Results: Elevated CA19-9 and mGPS, and body mass index (BMI) <20 kg/m² were significant indicators of poorer overall survival, while CA19-9 and BMI were validated as independent predictors of overall survival. In addition, BMI <20 kg/m² was a significant independent factor predictive of poorer diseasefree survival. BMI significantly negatively correlated with NLR, which reflects the patients' immune response. Conclusion: Lower BMI is a promising predictor of recurrence and poor prognosis in patients treated by laparoscopic surgery for CRC with curative intent.

Original language	English
Pages (from-to)	5639-5648
Number of pages	10
Journal	Anticancer research
Volume	35
Issue number	10
Publication status	Published - 01-10-2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Cite this

@article{c35a69fedfcb4ef2b2c561dd2b97c7ca,

title = "Preoperative lower body mass index correlates with poorer prognosis in patients undergoing curative laparoscopic surgery for colorectal cancer",

abstract = "Aim: The aim of this study was to investigate the correlations between clinicopathological findings, laboratory data and survival outcome in patients undergoing curative laparoscopic surgery for colorectal cancer (CRC). Patients and Methods: Clinicopathological findings and laboratory data, including tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) and systemic inflammatory response indicators, neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognosis score (mGPS), for 204 patients (tumor stage I-III) undergoing laparoscopic curative surgery for CRC were collected. Results: Elevated CA19-9 and mGPS, and body mass index (BMI) <20 kg/m2 were significant indicators of poorer overall survival, while CA19-9 and BMI were validated as independent predictors of overall survival. In addition, BMI <20 kg/m2 was a significant independent factor predictive of poorer diseasefree survival. BMI significantly negatively correlated with NLR, which reflects the patients' immune response. Conclusion: Lower BMI is a promising predictor of recurrence and poor prognosis in patients treated by laparoscopic surgery for CRC with curative intent.",

keywords = "Body mass index, Colorectal cancer, Laparoscopic surgery, Prognosis, Recurrence",

author = "Ryo Uratani and Yuji Toiyama and Tadanobu Shimura and Koichiro Mori and Hiroyuki Fujikawa and Jyunichiro Hiro and Masaki Ohi and Yasuhiro Inoue and Koji Tanaka and Toshimitsu Araki and Yasuhiko Mohri and Masato Kusunoki",

year = "2015",

month = oct,

day = "1",

language = "English",

volume = "35",

pages = "5639--5648",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "10",

}

TY - JOUR

T1 - Preoperative lower body mass index correlates with poorer prognosis in patients undergoing curative laparoscopic surgery for colorectal cancer

AU - Uratani, Ryo

AU - Toiyama, Yuji

AU - Shimura, Tadanobu

AU - Mori, Koichiro

AU - Fujikawa, Hiroyuki

AU - Hiro, Jyunichiro

AU - Ohi, Masaki

AU - Inoue, Yasuhiro

AU - Tanaka, Koji

AU - Araki, Toshimitsu

AU - Mohri, Yasuhiko

AU - Kusunoki, Masato

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Aim: The aim of this study was to investigate the correlations between clinicopathological findings, laboratory data and survival outcome in patients undergoing curative laparoscopic surgery for colorectal cancer (CRC). Patients and Methods: Clinicopathological findings and laboratory data, including tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) and systemic inflammatory response indicators, neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognosis score (mGPS), for 204 patients (tumor stage I-III) undergoing laparoscopic curative surgery for CRC were collected. Results: Elevated CA19-9 and mGPS, and body mass index (BMI) <20 kg/m2 were significant indicators of poorer overall survival, while CA19-9 and BMI were validated as independent predictors of overall survival. In addition, BMI <20 kg/m2 was a significant independent factor predictive of poorer diseasefree survival. BMI significantly negatively correlated with NLR, which reflects the patients' immune response. Conclusion: Lower BMI is a promising predictor of recurrence and poor prognosis in patients treated by laparoscopic surgery for CRC with curative intent.

AB - Aim: The aim of this study was to investigate the correlations between clinicopathological findings, laboratory data and survival outcome in patients undergoing curative laparoscopic surgery for colorectal cancer (CRC). Patients and Methods: Clinicopathological findings and laboratory data, including tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) and systemic inflammatory response indicators, neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognosis score (mGPS), for 204 patients (tumor stage I-III) undergoing laparoscopic curative surgery for CRC were collected. Results: Elevated CA19-9 and mGPS, and body mass index (BMI) <20 kg/m2 were significant indicators of poorer overall survival, while CA19-9 and BMI were validated as independent predictors of overall survival. In addition, BMI <20 kg/m2 was a significant independent factor predictive of poorer diseasefree survival. BMI significantly negatively correlated with NLR, which reflects the patients' immune response. Conclusion: Lower BMI is a promising predictor of recurrence and poor prognosis in patients treated by laparoscopic surgery for CRC with curative intent.

KW - Body mass index

KW - Colorectal cancer

KW - Laparoscopic surgery

KW - Prognosis

KW - Recurrence

UR - https://www.scopus.com/pages/publications/84942781473

UR - https://www.scopus.com/pages/publications/84942781473#tab=citedBy

M3 - Article

C2 - 26408737

AN - SCOPUS:84942781473

SN - 0250-7005

VL - 35

SP - 5639

EP - 5648

JO - Anticancer research

JF - Anticancer research

IS - 10

ER -

Preoperative lower body mass index correlates with poorer prognosis in patients undergoing curative laparoscopic surgery for colorectal cancer

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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