Preparation of zwitterionic polymethacrylamide modified with L-lysine and its effect on fibrinolytic activity

Kohei Shiraishi, Masushi Kohta, Kazuo Sugiyama

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Zwitterionic polymethacrylamides, poly(Nα-methacrylamide- L-lysine) [poly(α-LysMA)] and poly(Nε-methacrylamide-L- lysine) [poly(ε-LysMA)] were prepared to examine their bioactivity by an evaluation of fibrinolytic activity and a binding assay using resonant mirror biosensor (IAsys). Poly(α-LysMA) enhanced the fibrinolytic activity by plasminogen/tissue-type plasminogen activator while no enhancement was observed in the case of poly(ε-LysMA). A strong interaction between Plg to poly(α-LysMA) was also observed by IAsys when compared with poly(ε-LysMA).

Original languageEnglish
Pages (from-to)646-647
Number of pages2
JournalChemistry Letters
Volume33
Issue number6
DOIs
Publication statusPublished - 05-06-2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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