Preparation of zwitterionic polymethacrylamide modified with L-lysine and its effect on fibrinolytic activity

Kohei Shiraishi; Masushi Kohta; Kazuo Sugiyama

doi:10.1246/cl.2004.646

Preparation of zwitterionic polymethacrylamide modified with L-lysine and its effect on fibrinolytic activity

Kohei Shiraishi
, Masushi Kohta
, Kazuo Sugiyama

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Zwitterionic polymethacrylamides, poly(N^α-methacrylamide- L-lysine) [poly(α-LysMA)] and poly(N^ε-methacrylamide-L- lysine) [poly(ε-LysMA)] were prepared to examine their bioactivity by an evaluation of fibrinolytic activity and a binding assay using resonant mirror biosensor (IAsys). Poly(α-LysMA) enhanced the fibrinolytic activity by plasminogen/tissue-type plasminogen activator while no enhancement was observed in the case of poly(ε-LysMA). A strong interaction between Plg to poly(α-LysMA) was also observed by IAsys when compared with poly(ε-LysMA).

Original language	English
Pages (from-to)	646-647
Number of pages	2
Journal	Chemistry Letters
Volume	33
Issue number	6
DOIs	https://doi.org/10.1246/cl.2004.646
Publication status	Published - 05-06-2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry

Access to Document

10.1246/cl.2004.646

Cite this

@article{efd4f86c721d4277bf565198ab9175af,

title = "Preparation of zwitterionic polymethacrylamide modified with L-lysine and its effect on fibrinolytic activity",

abstract = "Zwitterionic polymethacrylamides, poly(Nα-methacrylamide- L-lysine) [poly(α-LysMA)] and poly(Nε-methacrylamide-L- lysine) [poly(ε-LysMA)] were prepared to examine their bioactivity by an evaluation of fibrinolytic activity and a binding assay using resonant mirror biosensor (IAsys). Poly(α-LysMA) enhanced the fibrinolytic activity by plasminogen/tissue-type plasminogen activator while no enhancement was observed in the case of poly(ε-LysMA). A strong interaction between Plg to poly(α-LysMA) was also observed by IAsys when compared with poly(ε-LysMA).",

author = "Kohei Shiraishi and Masushi Kohta and Kazuo Sugiyama",

year = "2004",

month = jun,

day = "5",

doi = "10.1246/cl.2004.646",

language = "English",

volume = "33",

pages = "646--647",

journal = "Chemistry Letters",

issn = "0366-7022",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Preparation of zwitterionic polymethacrylamide modified with L-lysine and its effect on fibrinolytic activity

AU - Shiraishi, Kohei

AU - Kohta, Masushi

AU - Sugiyama, Kazuo

PY - 2004/6/5

Y1 - 2004/6/5

N2 - Zwitterionic polymethacrylamides, poly(Nα-methacrylamide- L-lysine) [poly(α-LysMA)] and poly(Nε-methacrylamide-L- lysine) [poly(ε-LysMA)] were prepared to examine their bioactivity by an evaluation of fibrinolytic activity and a binding assay using resonant mirror biosensor (IAsys). Poly(α-LysMA) enhanced the fibrinolytic activity by plasminogen/tissue-type plasminogen activator while no enhancement was observed in the case of poly(ε-LysMA). A strong interaction between Plg to poly(α-LysMA) was also observed by IAsys when compared with poly(ε-LysMA).

AB - Zwitterionic polymethacrylamides, poly(Nα-methacrylamide- L-lysine) [poly(α-LysMA)] and poly(Nε-methacrylamide-L- lysine) [poly(ε-LysMA)] were prepared to examine their bioactivity by an evaluation of fibrinolytic activity and a binding assay using resonant mirror biosensor (IAsys). Poly(α-LysMA) enhanced the fibrinolytic activity by plasminogen/tissue-type plasminogen activator while no enhancement was observed in the case of poly(ε-LysMA). A strong interaction between Plg to poly(α-LysMA) was also observed by IAsys when compared with poly(ε-LysMA).

UR - https://www.scopus.com/pages/publications/4444366096

UR - https://www.scopus.com/pages/publications/4444366096#tab=citedBy

U2 - 10.1246/cl.2004.646

DO - 10.1246/cl.2004.646

M3 - Article

AN - SCOPUS:4444366096

SN - 0366-7022

VL - 33

SP - 646

EP - 647

JO - Chemistry Letters

JF - Chemistry Letters

IS - 6

ER -

Preparation of zwitterionic polymethacrylamide modified with L-lysine and its effect on fibrinolytic activity

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this