Prepulse inhibition of the startle response with chronic schizophrenia

A replication study

Masatsugu Moriwaki, Taro Kishi, Hidetoshi Takahashi, Ryota Hashimoto, Kunihiro Kawashima, Tomo Okochi, Tsuyoshi Kitajima, Osamu Furukawa, Kiyoshi Fujita, Masatoshi Takeda, Nakao Iwata

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Prepulse inhibition (PPI) deficit, the acoustic startle reflex (ASR) and habituation (HAB) impairment are considered to be endophenotypes for schizophrenia. The recent two studies have reported that a PPI deficit was detected in Japanese schizophrenic patients. We replicated that study using larger samples (115 schizophrenic patients and 111 normal controls) than the original study and a method same as original study. A startle response monitoring system was used to deliver acoustic startle stimuli, and to record and score the electromyographic activity of the orbicularis oculi muscle. We evaluated the startle measures of mean magnitude of ASR, HAB, and PPI at prepulse sound pressure intensities of 82 dB (PPI82), 86 dB (PPI86), and 90 dB (PPI90). ASR was significantly different between schizophrenic patients and controls. HAB and all PPI session data from schizophrenic patients were significantly lower than in controls. In addition, we detected significant differences for ASR, HAB and each PPI (82, 86 and 90 dB) between schizophrenic patients and controls with the use of multiple regression analysis. The gender and smoking state were not correlated with ASR, HAB or any PPI in multiple regression analysis. In conclusion, we were able to replicate the finding of HAB impairment and PPI deficit in chronic Japanese schizophrenic patients.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalNeuroscience Research
Volume65
Issue number3
DOIs
Publication statusPublished - 01-11-2009

Fingerprint

Startle Reflex
Schizophrenia
Regression Analysis
Endophenotypes
Prepulse Inhibition
Acoustics
Smoking
Pressure
Muscles

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Moriwaki, Masatsugu ; Kishi, Taro ; Takahashi, Hidetoshi ; Hashimoto, Ryota ; Kawashima, Kunihiro ; Okochi, Tomo ; Kitajima, Tsuyoshi ; Furukawa, Osamu ; Fujita, Kiyoshi ; Takeda, Masatoshi ; Iwata, Nakao. / Prepulse inhibition of the startle response with chronic schizophrenia : A replication study. In: Neuroscience Research. 2009 ; Vol. 65, No. 3. pp. 259-262.
@article{34e55481762e4556b47fc44168e9e3c6,
title = "Prepulse inhibition of the startle response with chronic schizophrenia: A replication study",
abstract = "Prepulse inhibition (PPI) deficit, the acoustic startle reflex (ASR) and habituation (HAB) impairment are considered to be endophenotypes for schizophrenia. The recent two studies have reported that a PPI deficit was detected in Japanese schizophrenic patients. We replicated that study using larger samples (115 schizophrenic patients and 111 normal controls) than the original study and a method same as original study. A startle response monitoring system was used to deliver acoustic startle stimuli, and to record and score the electromyographic activity of the orbicularis oculi muscle. We evaluated the startle measures of mean magnitude of ASR, HAB, and PPI at prepulse sound pressure intensities of 82 dB (PPI82), 86 dB (PPI86), and 90 dB (PPI90). ASR was significantly different between schizophrenic patients and controls. HAB and all PPI session data from schizophrenic patients were significantly lower than in controls. In addition, we detected significant differences for ASR, HAB and each PPI (82, 86 and 90 dB) between schizophrenic patients and controls with the use of multiple regression analysis. The gender and smoking state were not correlated with ASR, HAB or any PPI in multiple regression analysis. In conclusion, we were able to replicate the finding of HAB impairment and PPI deficit in chronic Japanese schizophrenic patients.",
author = "Masatsugu Moriwaki and Taro Kishi and Hidetoshi Takahashi and Ryota Hashimoto and Kunihiro Kawashima and Tomo Okochi and Tsuyoshi Kitajima and Osamu Furukawa and Kiyoshi Fujita and Masatoshi Takeda and Nakao Iwata",
year = "2009",
month = "11",
day = "1",
doi = "10.1016/j.neures.2009.07.009",
language = "English",
volume = "65",
pages = "259--262",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

Moriwaki, M, Kishi, T, Takahashi, H, Hashimoto, R, Kawashima, K, Okochi, T, Kitajima, T, Furukawa, O, Fujita, K, Takeda, M & Iwata, N 2009, 'Prepulse inhibition of the startle response with chronic schizophrenia: A replication study', Neuroscience Research, vol. 65, no. 3, pp. 259-262. https://doi.org/10.1016/j.neures.2009.07.009

Prepulse inhibition of the startle response with chronic schizophrenia : A replication study. / Moriwaki, Masatsugu; Kishi, Taro; Takahashi, Hidetoshi; Hashimoto, Ryota; Kawashima, Kunihiro; Okochi, Tomo; Kitajima, Tsuyoshi; Furukawa, Osamu; Fujita, Kiyoshi; Takeda, Masatoshi; Iwata, Nakao.

In: Neuroscience Research, Vol. 65, No. 3, 01.11.2009, p. 259-262.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prepulse inhibition of the startle response with chronic schizophrenia

T2 - A replication study

AU - Moriwaki, Masatsugu

AU - Kishi, Taro

AU - Takahashi, Hidetoshi

AU - Hashimoto, Ryota

AU - Kawashima, Kunihiro

AU - Okochi, Tomo

AU - Kitajima, Tsuyoshi

AU - Furukawa, Osamu

AU - Fujita, Kiyoshi

AU - Takeda, Masatoshi

AU - Iwata, Nakao

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Prepulse inhibition (PPI) deficit, the acoustic startle reflex (ASR) and habituation (HAB) impairment are considered to be endophenotypes for schizophrenia. The recent two studies have reported that a PPI deficit was detected in Japanese schizophrenic patients. We replicated that study using larger samples (115 schizophrenic patients and 111 normal controls) than the original study and a method same as original study. A startle response monitoring system was used to deliver acoustic startle stimuli, and to record and score the electromyographic activity of the orbicularis oculi muscle. We evaluated the startle measures of mean magnitude of ASR, HAB, and PPI at prepulse sound pressure intensities of 82 dB (PPI82), 86 dB (PPI86), and 90 dB (PPI90). ASR was significantly different between schizophrenic patients and controls. HAB and all PPI session data from schizophrenic patients were significantly lower than in controls. In addition, we detected significant differences for ASR, HAB and each PPI (82, 86 and 90 dB) between schizophrenic patients and controls with the use of multiple regression analysis. The gender and smoking state were not correlated with ASR, HAB or any PPI in multiple regression analysis. In conclusion, we were able to replicate the finding of HAB impairment and PPI deficit in chronic Japanese schizophrenic patients.

AB - Prepulse inhibition (PPI) deficit, the acoustic startle reflex (ASR) and habituation (HAB) impairment are considered to be endophenotypes for schizophrenia. The recent two studies have reported that a PPI deficit was detected in Japanese schizophrenic patients. We replicated that study using larger samples (115 schizophrenic patients and 111 normal controls) than the original study and a method same as original study. A startle response monitoring system was used to deliver acoustic startle stimuli, and to record and score the electromyographic activity of the orbicularis oculi muscle. We evaluated the startle measures of mean magnitude of ASR, HAB, and PPI at prepulse sound pressure intensities of 82 dB (PPI82), 86 dB (PPI86), and 90 dB (PPI90). ASR was significantly different between schizophrenic patients and controls. HAB and all PPI session data from schizophrenic patients were significantly lower than in controls. In addition, we detected significant differences for ASR, HAB and each PPI (82, 86 and 90 dB) between schizophrenic patients and controls with the use of multiple regression analysis. The gender and smoking state were not correlated with ASR, HAB or any PPI in multiple regression analysis. In conclusion, we were able to replicate the finding of HAB impairment and PPI deficit in chronic Japanese schizophrenic patients.

UR - http://www.scopus.com/inward/record.url?scp=70349469579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349469579&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2009.07.009

DO - 10.1016/j.neures.2009.07.009

M3 - Article

VL - 65

SP - 259

EP - 262

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 3

ER -

Moriwaki M, Kishi T, Takahashi H, Hashimoto R, Kawashima K, Okochi T et al. Prepulse inhibition of the startle response with chronic schizophrenia: A replication study. Neuroscience Research. 2009 Nov 1;65(3):259-262. https://doi.org/10.1016/j.neures.2009.07.009