Abstract
Background and Objective Pharmacological treatment of schizophrenic patients in Japan is characterized by polypharmacy with high doses of antipsychotics. In this study, we examined the profiles of antipsychotic drug therapy in 2007 and 2009 to determine if there have been any recent shifts in treatment strategy. Method The subjects were schizophrenic inpatients (ICD-10-F20) admitted to 100 hospitals in 2007 and 152 hospitals in 2009. Information on the psychotropic agents prescribed on specified days in November 2007 and 2009 was acquired for each patient. Results Although no changes were observed in the rate of antipsychotic medications being prescribed, the rate of antipsychotic monotherapy in 2009 increased significantly. In 2007, among 15,761 patients, 4977 (31.6%) received antipsychotic monotherapy (i.e., administration of a single antipsychotic medication). In 2009, among 22,911 patients, 7741 (33.8%) received antipsychotic monotherapy. Conclusion The rate of use of antipsychotic monotherapy has gradually increased, although the total dose has not changed significantly. The increase in the concomitant use of two or more second-generation antipsychotics is a recent trend in Japan, despite the lack of information on the efficacy and safety of this treatment strategy.
| Original language | English |
|---|---|
| Pages (from-to) | 70-75 |
| Number of pages | 6 |
| Journal | Human Psychopharmacology |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 01-01-2012 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Pharmacology (medical)
Cite this
}
Prescription profiles for pharmacological treatment of Japanese inpatients with schizophrenia : Comparison between 2007 and 2009. / Yoshio, Takashi; Inada, Toshiya; Uno, Junji; Miwa, Takaichi; Kitagawa, Kohei; Miyahara, Yoshiki; Umeda, Kenta; Kato, Tsuyoshi; Inagaki, Ataru; Nabeshima, Toshitaka.
In: Human Psychopharmacology, Vol. 27, No. 1, 01.01.2012, p. 70-75.Research output: Contribution to journal › Article
TY - JOUR
T1 - Prescription profiles for pharmacological treatment of Japanese inpatients with schizophrenia
T2 - Comparison between 2007 and 2009
AU - Yoshio, Takashi
AU - Inada, Toshiya
AU - Uno, Junji
AU - Miwa, Takaichi
AU - Kitagawa, Kohei
AU - Miyahara, Yoshiki
AU - Umeda, Kenta
AU - Kato, Tsuyoshi
AU - Inagaki, Ataru
AU - Nabeshima, Toshitaka
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Background and Objective Pharmacological treatment of schizophrenic patients in Japan is characterized by polypharmacy with high doses of antipsychotics. In this study, we examined the profiles of antipsychotic drug therapy in 2007 and 2009 to determine if there have been any recent shifts in treatment strategy. Method The subjects were schizophrenic inpatients (ICD-10-F20) admitted to 100 hospitals in 2007 and 152 hospitals in 2009. Information on the psychotropic agents prescribed on specified days in November 2007 and 2009 was acquired for each patient. Results Although no changes were observed in the rate of antipsychotic medications being prescribed, the rate of antipsychotic monotherapy in 2009 increased significantly. In 2007, among 15,761 patients, 4977 (31.6%) received antipsychotic monotherapy (i.e., administration of a single antipsychotic medication). In 2009, among 22,911 patients, 7741 (33.8%) received antipsychotic monotherapy. Conclusion The rate of use of antipsychotic monotherapy has gradually increased, although the total dose has not changed significantly. The increase in the concomitant use of two or more second-generation antipsychotics is a recent trend in Japan, despite the lack of information on the efficacy and safety of this treatment strategy.
AB - Background and Objective Pharmacological treatment of schizophrenic patients in Japan is characterized by polypharmacy with high doses of antipsychotics. In this study, we examined the profiles of antipsychotic drug therapy in 2007 and 2009 to determine if there have been any recent shifts in treatment strategy. Method The subjects were schizophrenic inpatients (ICD-10-F20) admitted to 100 hospitals in 2007 and 152 hospitals in 2009. Information on the psychotropic agents prescribed on specified days in November 2007 and 2009 was acquired for each patient. Results Although no changes were observed in the rate of antipsychotic medications being prescribed, the rate of antipsychotic monotherapy in 2009 increased significantly. In 2007, among 15,761 patients, 4977 (31.6%) received antipsychotic monotherapy (i.e., administration of a single antipsychotic medication). In 2009, among 22,911 patients, 7741 (33.8%) received antipsychotic monotherapy. Conclusion The rate of use of antipsychotic monotherapy has gradually increased, although the total dose has not changed significantly. The increase in the concomitant use of two or more second-generation antipsychotics is a recent trend in Japan, despite the lack of information on the efficacy and safety of this treatment strategy.
UR - http://www.scopus.com/inward/record.url?scp=84856321088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856321088&partnerID=8YFLogxK
U2 - 10.1002/hup.1272
DO - 10.1002/hup.1272
M3 - Article
C2 - 22249957
AN - SCOPUS:84856321088
VL - 27
SP - 70
EP - 75
JO - Human Psychopharmacology
JF - Human Psychopharmacology
SN - 0885-6222
IS - 1
ER -