Present and future of reverse genetics of rotavirus

Research output: Contribution to journalReview articlepeer-review

Abstract

Rotavirus is the leading pathogen for acute gastroenteritis in mammals and birds. Although the reverse genetics system has been utilized in many viruses, the system using a helper virus was developed for rotavirus in 2006. As a step for antigenic analysis of VP4 antigen of rotavirus, we prepared an infectious rotavirus with a spike protein VP4 having an antigenic mosaic by substituting one of the cross-reactive neutralization epitopes of a simian strain SA-11 with the corresponding one of a human strain DS-1. The future improvement and application of the rotavirus reverse genetics were discussed in this review.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalUirusu. Journal of virology
Volume59
Issue number1
DOIs
Publication statusPublished - 06-2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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