Abstract
Rotavirus is the leading pathogen for acute gastroenteritis in mammals and birds. Although the reverse genetics system has been utilized in many viruses, the system using a helper virus was developed for rotavirus in 2006. As a step for antigenic analysis of VP4 antigen of rotavirus, we prepared an infectious rotavirus with a spike protein VP4 having an antigenic mosaic by substituting one of the cross-reactive neutralization epitopes of a simian strain SA-11 with the corresponding one of a human strain DS-1. The future improvement and application of the rotavirus reverse genetics were discussed in this review.
Original language | English |
---|---|
Pages (from-to) | 91-98 |
Number of pages | 8 |
Journal | Uirusu. Journal of virology |
Volume | 59 |
Issue number | 1 |
DOIs | |
Publication status | Published - 06-2009 |
All Science Journal Classification (ASJC) codes
- General Medicine