Present and future of reverse genetics of rotavirus

Koki Taniguchi; Satoshi Komoto; Jun Sasaki; Masanori Kugita

doi:10.2222/jsv.59.91

Present and future of reverse genetics of rotavirus

Koki Taniguchi
, Satoshi Komoto
, Jun Sasaki
, Masanori Kugita

Research output: Contribution to journal › Review article › peer-review

Abstract

Rotavirus is the leading pathogen for acute gastroenteritis in mammals and birds. Although the reverse genetics system has been utilized in many viruses, the system using a helper virus was developed for rotavirus in 2006. As a step for antigenic analysis of VP4 antigen of rotavirus, we prepared an infectious rotavirus with a spike protein VP4 having an antigenic mosaic by substituting one of the cross-reactive neutralization epitopes of a simian strain SA-11 with the corresponding one of a human strain DS-1. The future improvement and application of the rotavirus reverse genetics were discussed in this review.

Original language	English
Pages (from-to)	91-98
Number of pages	8
Journal	Uirusu. Journal of virology
Volume	59
Issue number	1
DOIs	https://doi.org/10.2222/jsv.59.91
Publication status	Published - 06-2009

All Science Journal Classification (ASJC) codes

General Medicine

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10.2222/jsv.59.91

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title = "Present and future of reverse genetics of rotavirus",

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AU - Komoto, Satoshi

AU - Sasaki, Jun

AU - Kugita, Masanori

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N2 - Rotavirus is the leading pathogen for acute gastroenteritis in mammals and birds. Although the reverse genetics system has been utilized in many viruses, the system using a helper virus was developed for rotavirus in 2006. As a step for antigenic analysis of VP4 antigen of rotavirus, we prepared an infectious rotavirus with a spike protein VP4 having an antigenic mosaic by substituting one of the cross-reactive neutralization epitopes of a simian strain SA-11 with the corresponding one of a human strain DS-1. The future improvement and application of the rotavirus reverse genetics were discussed in this review.

AB - Rotavirus is the leading pathogen for acute gastroenteritis in mammals and birds. Although the reverse genetics system has been utilized in many viruses, the system using a helper virus was developed for rotavirus in 2006. As a step for antigenic analysis of VP4 antigen of rotavirus, we prepared an infectious rotavirus with a spike protein VP4 having an antigenic mosaic by substituting one of the cross-reactive neutralization epitopes of a simian strain SA-11 with the corresponding one of a human strain DS-1. The future improvement and application of the rotavirus reverse genetics were discussed in this review.

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Present and future of reverse genetics of rotavirus

Abstract

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