TY - JOUR
T1 - Prevalence and clinical characterization of patients with acute hepatitis B induced by lamivudine-resistant strains
AU - Hayashi, Kazuhiko
AU - Katano, Yoshiaki
AU - Ishigami, Masatoshi
AU - Itoh, Akihiro
AU - Hirooka, Yoshiki
AU - Nakano, Isao
AU - Yoshioka, Kentaro
AU - Yano, Motoyoshi
AU - Toyoda, Hidenori
AU - Kumada, Takashi
AU - Goto, Hidemi
PY - 2010/4
Y1 - 2010/4
N2 - Background and Aims: Acute hepatitis caused by lamivudine (LMV)-resistant strains has not been reported, and the clinical impact of LMV-resistant strains on acute hepatitis is not known. The aim of this study was to investigate the molecular and clinical characteristics of patients with acute hepatitis B caused by LMV-resistant strains. Methods: Forty-five patients with acute hepatitis B were studied. Hepatitis B virus (HBV) subgenotypes and LMV-resistance mutations were determined by direct sequencing of the preS and polymerase regions, respectively. Results: HBV subgenotypes A2 (n = 18), B1 (n = 1), B2 (n = 3), B3 (n = 2), C1 (n = 1), C2 (n = 19) and C6 (n = 1) were detected in patients with acute hepatitis. LMV-resistance mutations were detected in two patients. LMV-resistance mutations (L180M, M204I) were detected in a patient with subgenotype C2 who had acute self-limited hepatitis. The other patient with LMV-resistance mutations (L180M, M204V) was infected with subgenotype A2 and had severe hepatitis. Conclusion: LMV-resistant strains are rare, but they are starting to be found in patients with acute hepatitis B. Surveillance for detecting drug-resistant HBV strains would be important for clinical practice.
AB - Background and Aims: Acute hepatitis caused by lamivudine (LMV)-resistant strains has not been reported, and the clinical impact of LMV-resistant strains on acute hepatitis is not known. The aim of this study was to investigate the molecular and clinical characteristics of patients with acute hepatitis B caused by LMV-resistant strains. Methods: Forty-five patients with acute hepatitis B were studied. Hepatitis B virus (HBV) subgenotypes and LMV-resistance mutations were determined by direct sequencing of the preS and polymerase regions, respectively. Results: HBV subgenotypes A2 (n = 18), B1 (n = 1), B2 (n = 3), B3 (n = 2), C1 (n = 1), C2 (n = 19) and C6 (n = 1) were detected in patients with acute hepatitis. LMV-resistance mutations were detected in two patients. LMV-resistance mutations (L180M, M204I) were detected in a patient with subgenotype C2 who had acute self-limited hepatitis. The other patient with LMV-resistance mutations (L180M, M204V) was infected with subgenotype A2 and had severe hepatitis. Conclusion: LMV-resistant strains are rare, but they are starting to be found in patients with acute hepatitis B. Surveillance for detecting drug-resistant HBV strains would be important for clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=77950124622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950124622&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1746.2009.06118.x
DO - 10.1111/j.1440-1746.2009.06118.x
M3 - Article
C2 - 20074155
AN - SCOPUS:77950124622
SN - 0815-9319
VL - 25
SP - 745
EP - 749
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
IS - 4
ER -
