Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study

Kanji Mori; Toshitaka Yoshii; Takashi Hirai; Akio Iwanami; Kazuhiro Takeuchi; Tsuyoshi Yamada; Shoji Seki; Takashi Tsuji; Kanehiro Fujiyoshi; Mitsuru Furukawa; Soraya Nishimura; Kanichiro Wada; Masao Koda; Takeo Furuya; Yukihiro Matsuyama; Tomohiko Hasegawa; Katsushi Takeshita; Atsushi Kimura; Masahiko Abematsu; Hirotaka Haro; Tetsuro Ohba; Masahiko Watanabe; Hiroyuki Katoh; Kei Watanabe; Hiroshi Ozawa; Haruo Kanno; Shiro Imagama; Zenya Ito; Shunsuke Fujibayashi; Masashi Yamazaki; Morio Matsumoto; Masaya Nakamura; Atsushi Okawa; Yoshiharu Kawaguchi

doi:10.1186/s12891-016-1350-y

Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study

Kanji Mori, Toshitaka Yoshii, Takashi Hirai, Akio Iwanami, Kazuhiro Takeuchi, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Soraya Nishimura, Kanichiro Wada, Masao Koda, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko Abematsu, Hirotaka HaroTetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Zenya Ito, Shunsuke Fujibayashi, Masashi Yamazaki, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi

Spine and Spinal Cord Surgery

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Background: Supra/interspinous ligaments connect adjacent spinous processes and act as a stabilizer of the spine. As with other spinal ligaments, it can become ossified. However, few report have discussed ossification supra/interspinous ligaments (OSIL), so its epidemiology remains unknown. We therefore aimed to investigate the prevalence and distribution of OSIL in symptomatic patients with cervical ossification of the posterior longitudinal ligament (OPLL). Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. The whole spine CT data as well as clinical parameters such as age and sex were obtained from 20 institutions belong to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament (JOSL). The prevalence and distribution of OSIL and the association between OSIL and clinical parameters were reviewed. The sum of the levels involved by OPLL (OP-index) and OSIL (OSI-index) as well as the prevalence of ossification of the nuchal ligament (ONL) were also investigated. Results: A total of 234 patients with a mean age of 65 years was recruited. The CT-based evidence of OSIL was noted in 68 (54 males and 14 females) patients (29%). The distribution of OSIL showed a significant thoracic preponderance. In OSIL-positive patients, single-level involvement was noted in 19 cases (28%), whereas 49 cases (72%) presented multi-level involvement. We found a significant positive correlation between the OP-index grade and OSI-index. ONL was noted at a significantly higher rate in OSIL-positive patients compared to negative patients. Conclusions: The prevalence of OSIL in symptomatic patients with cervical OPLL was 29%. The distribution of OSIL showed a significant thoracic preponderance.

Original language	English
Article number	492
Pages (from-to)	1-7
Number of pages	7
Journal	BMC Musculoskeletal Disorders
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12891-016-1350-y
Publication status	Published - 01-12-2016

All Science Journal Classification (ASJC) codes

Rheumatology
Orthopedics and Sports Medicine

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10.1186/s12891-016-1350-y

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Mori, K., Yoshii, T., Hirai, T., Iwanami, A., Takeuchi, K., Yamada, T., Seki, S., Tsuji, T., Fujiyoshi, K., Furukawa, M., Nishimura, S., Wada, K., Koda, M., Furuya, T., Matsuyama, Y., Hasegawa, T., Takeshita, K., Kimura, A., Abematsu, M., ... Kawaguchi, Y. (2016). Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study. BMC Musculoskeletal Disorders, 17(1), 1-7. Article 492. https://doi.org/10.1186/s12891-016-1350-y

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title = "Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study",

abstract = "Background: Supra/interspinous ligaments connect adjacent spinous processes and act as a stabilizer of the spine. As with other spinal ligaments, it can become ossified. However, few report have discussed ossification supra/interspinous ligaments (OSIL), so its epidemiology remains unknown. We therefore aimed to investigate the prevalence and distribution of OSIL in symptomatic patients with cervical ossification of the posterior longitudinal ligament (OPLL). Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. The whole spine CT data as well as clinical parameters such as age and sex were obtained from 20 institutions belong to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament (JOSL). The prevalence and distribution of OSIL and the association between OSIL and clinical parameters were reviewed. The sum of the levels involved by OPLL (OP-index) and OSIL (OSI-index) as well as the prevalence of ossification of the nuchal ligament (ONL) were also investigated. Results: A total of 234 patients with a mean age of 65 years was recruited. The CT-based evidence of OSIL was noted in 68 (54 males and 14 females) patients (29%). The distribution of OSIL showed a significant thoracic preponderance. In OSIL-positive patients, single-level involvement was noted in 19 cases (28%), whereas 49 cases (72%) presented multi-level involvement. We found a significant positive correlation between the OP-index grade and OSI-index. ONL was noted at a significantly higher rate in OSIL-positive patients compared to negative patients. Conclusions: The prevalence of OSIL in symptomatic patients with cervical OPLL was 29%. The distribution of OSIL showed a significant thoracic preponderance.",

keywords = "Ankylosed spine, Computed tomography, DISH, Epidemiology, OLF, OPLL, Ossification, Prevalence, Supra/interspinous ligaments, Whole spine",

author = "Kanji Mori and Toshitaka Yoshii and Takashi Hirai and Akio Iwanami and Kazuhiro Takeuchi and Tsuyoshi Yamada and Shoji Seki and Takashi Tsuji and Kanehiro Fujiyoshi and Mitsuru Furukawa and Soraya Nishimura and Kanichiro Wada and Masao Koda and Takeo Furuya and Yukihiro Matsuyama and Tomohiko Hasegawa and Katsushi Takeshita and Atsushi Kimura and Masahiko Abematsu and Hirotaka Haro and Tetsuro Ohba and Masahiko Watanabe and Hiroyuki Katoh and Kei Watanabe and Hiroshi Ozawa and Haruo Kanno and Shiro Imagama and Zenya Ito and Shunsuke Fujibayashi and Masashi Yamazaki and Morio Matsumoto and Masaya Nakamura and Atsushi Okawa and Yoshiharu Kawaguchi",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

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day = "1",

doi = "10.1186/s12891-016-1350-y",

language = "English",

volume = "17",

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Mori, K, Yoshii, T, Hirai, T, Iwanami, A, Takeuchi, K, Yamada, T, Seki, S, Tsuji, T, Fujiyoshi, K, Furukawa, M, Nishimura, S, Wada, K, Koda, M, Furuya, T, Matsuyama, Y, Hasegawa, T, Takeshita, K, Kimura, A, Abematsu, M, Haro, H, Ohba, T, Watanabe, M, Katoh, H, Watanabe, K, Ozawa, H, Kanno, H, Imagama, S, Ito, Z, Fujibayashi, S, Yamazaki, M, Matsumoto, M, Nakamura, M, Okawa, A & Kawaguchi, Y 2016, 'Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study', BMC Musculoskeletal Disorders, vol. 17, no. 1, 492, pp. 1-7. https://doi.org/10.1186/s12891-016-1350-y

Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study. / Mori, Kanji; Yoshii, Toshitaka; Hirai, Takashi et al.
In: BMC Musculoskeletal Disorders, Vol. 17, No. 1, 492, 01.12.2016, p. 1-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine

T2 - a CT-based multicenter cross-sectional study

AU - Mori, Kanji

AU - Yoshii, Toshitaka

AU - Hirai, Takashi

AU - Iwanami, Akio

AU - Takeuchi, Kazuhiro

AU - Yamada, Tsuyoshi

AU - Seki, Shoji

AU - Tsuji, Takashi

AU - Fujiyoshi, Kanehiro

AU - Furukawa, Mitsuru

AU - Nishimura, Soraya

AU - Wada, Kanichiro

AU - Koda, Masao

AU - Furuya, Takeo

AU - Matsuyama, Yukihiro

AU - Hasegawa, Tomohiko

AU - Takeshita, Katsushi

AU - Kimura, Atsushi

AU - Abematsu, Masahiko

AU - Haro, Hirotaka

AU - Ohba, Tetsuro

AU - Watanabe, Masahiko

AU - Katoh, Hiroyuki

AU - Watanabe, Kei

AU - Ozawa, Hiroshi

AU - Kanno, Haruo

AU - Imagama, Shiro

AU - Ito, Zenya

AU - Fujibayashi, Shunsuke

AU - Yamazaki, Masashi

AU - Matsumoto, Morio

AU - Nakamura, Masaya

AU - Okawa, Atsushi

AU - Kawaguchi, Yoshiharu

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: Supra/interspinous ligaments connect adjacent spinous processes and act as a stabilizer of the spine. As with other spinal ligaments, it can become ossified. However, few report have discussed ossification supra/interspinous ligaments (OSIL), so its epidemiology remains unknown. We therefore aimed to investigate the prevalence and distribution of OSIL in symptomatic patients with cervical ossification of the posterior longitudinal ligament (OPLL). Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. The whole spine CT data as well as clinical parameters such as age and sex were obtained from 20 institutions belong to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament (JOSL). The prevalence and distribution of OSIL and the association between OSIL and clinical parameters were reviewed. The sum of the levels involved by OPLL (OP-index) and OSIL (OSI-index) as well as the prevalence of ossification of the nuchal ligament (ONL) were also investigated. Results: A total of 234 patients with a mean age of 65 years was recruited. The CT-based evidence of OSIL was noted in 68 (54 males and 14 females) patients (29%). The distribution of OSIL showed a significant thoracic preponderance. In OSIL-positive patients, single-level involvement was noted in 19 cases (28%), whereas 49 cases (72%) presented multi-level involvement. We found a significant positive correlation between the OP-index grade and OSI-index. ONL was noted at a significantly higher rate in OSIL-positive patients compared to negative patients. Conclusions: The prevalence of OSIL in symptomatic patients with cervical OPLL was 29%. The distribution of OSIL showed a significant thoracic preponderance.

AB - Background: Supra/interspinous ligaments connect adjacent spinous processes and act as a stabilizer of the spine. As with other spinal ligaments, it can become ossified. However, few report have discussed ossification supra/interspinous ligaments (OSIL), so its epidemiology remains unknown. We therefore aimed to investigate the prevalence and distribution of OSIL in symptomatic patients with cervical ossification of the posterior longitudinal ligament (OPLL). Methods: The participants of our study were symptomatic patients with cervical OPLL who were diagnosed by standard radiographs of the cervical spine. The whole spine CT data as well as clinical parameters such as age and sex were obtained from 20 institutions belong to the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament (JOSL). The prevalence and distribution of OSIL and the association between OSIL and clinical parameters were reviewed. The sum of the levels involved by OPLL (OP-index) and OSIL (OSI-index) as well as the prevalence of ossification of the nuchal ligament (ONL) were also investigated. Results: A total of 234 patients with a mean age of 65 years was recruited. The CT-based evidence of OSIL was noted in 68 (54 males and 14 females) patients (29%). The distribution of OSIL showed a significant thoracic preponderance. In OSIL-positive patients, single-level involvement was noted in 19 cases (28%), whereas 49 cases (72%) presented multi-level involvement. We found a significant positive correlation between the OP-index grade and OSI-index. ONL was noted at a significantly higher rate in OSIL-positive patients compared to negative patients. Conclusions: The prevalence of OSIL in symptomatic patients with cervical OPLL was 29%. The distribution of OSIL showed a significant thoracic preponderance.

KW - Ankylosed spine

KW - Computed tomography

KW - DISH

KW - Epidemiology

KW - OLF

KW - OPLL

KW - Ossification

KW - Prevalence

KW - Supra/interspinous ligaments

KW - Whole spine

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UR - http://www.scopus.com/inward/citedby.url?scp=85000416492&partnerID=8YFLogxK

U2 - 10.1186/s12891-016-1350-y

DO - 10.1186/s12891-016-1350-y

M3 - Article

C2 - 27903251

AN - SCOPUS:85000416492

SN - 1471-2474

VL - 17

SP - 1

EP - 7

JO - BMC Musculoskeletal Disorders

JF - BMC Musculoskeletal Disorders

IS - 1

M1 - 492

ER -

Mori K, Yoshii T, Hirai T, Iwanami A, Takeuchi K, Yamada T et al. Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study. BMC Musculoskeletal Disorders. 2016 Dec 1;17(1):1-7. 492. doi: 10.1186/s12891-016-1350-y

Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study

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