TY - JOUR
T1 - Prevalence and Risk Factor Analysis of Post-Intensive Care Syndrome in Patients with COVID-19 Requiring Mechanical Ventilation
T2 - A Multicenter Prospective Observational Study
AU - Hatakeyama, Junji
AU - Inoue, Shigeaki
AU - Liu, Keibun
AU - Yamakawa, Kazuma
AU - Nishida, Takeshi
AU - Ohshimo, Shinichiro
AU - Hashimoto, Satoru
AU - Kanda, Naoki
AU - Maruyama, Shuhei
AU - Ogata, Yoshitaka
AU - Kawakami, Daisuke
AU - Shimizu, Hiroaki
AU - Hayakawa, Katsura
AU - Tanaka, Aiko
AU - Oshima, Taku
AU - Fuchigami, Tatsuya
AU - Yawata, Hironori
AU - Oe, Kyoji
AU - Kawauchi, Akira
AU - Yamagata, Hidehiro
AU - Harada, Masahiro
AU - Sato, Yuichi
AU - Nakamura, Tomoyuki
AU - Sugiki, Kei
AU - Hakozaki, Takahiro
AU - Beppu, Satoru
AU - Anraku, Masaki
AU - Kato, Noboru
AU - Iwashita, Tomomi
AU - Kamijo, Hiroshi
AU - Kitagawa, Yuichiro
AU - Nagashima, Michio
AU - Nishimaki, Hirona
AU - Tokuda, Kentaro
AU - Nishida, Osamu
AU - Nakamura, Kensuke
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/10
Y1 - 2022/10
N2 - Introduction: Post-intensive care syndrome (PICS) is an emerging problem in critically ill patients and the prevalence and risk factors are unclear in patients with severe coronavirus disease 2019 (COVID-19). This multicenter prospective observational study aimed to investigate the prevalence and risk factors of PICS in ventilated patients with COVID-19 after ICU discharge. Methods: Questionnaires were administered twice in surviving patients with COVID-19 who had required mechanical ventilation, concerning Barthel Index, Short-Memory Questionnaire, and Hospital Anxiety and Depression Scale scores. The risk factors for PICS were examined using a multivariate logistic regression analysis. Results: The first and second PICS surveys were obtained at 5.5 and 13.5 months (mean) after ICU discharge, with 251 and 209 patients completing the questionnaires and with a prevalence of PICS of 58.6% and 60.8%, respectively, along with the highest percentages of cognitive impairment. Delirium (with an odds ratio of (OR) 2.34, 95% CI 1.1–4.9, and p = 0.03) and the duration of mechanical ventilation (with an OR of 1.29, 95% CI 1.05–1.58, and p = 0.02) were independently identified as the risk factors for PICS in the first PICS survey. Conclusion: Approximately 60% of the ventilated patients with COVID-19 experienced persistent PICS, especially delirium, and required longer mechanical ventilation.
AB - Introduction: Post-intensive care syndrome (PICS) is an emerging problem in critically ill patients and the prevalence and risk factors are unclear in patients with severe coronavirus disease 2019 (COVID-19). This multicenter prospective observational study aimed to investigate the prevalence and risk factors of PICS in ventilated patients with COVID-19 after ICU discharge. Methods: Questionnaires were administered twice in surviving patients with COVID-19 who had required mechanical ventilation, concerning Barthel Index, Short-Memory Questionnaire, and Hospital Anxiety and Depression Scale scores. The risk factors for PICS were examined using a multivariate logistic regression analysis. Results: The first and second PICS surveys were obtained at 5.5 and 13.5 months (mean) after ICU discharge, with 251 and 209 patients completing the questionnaires and with a prevalence of PICS of 58.6% and 60.8%, respectively, along with the highest percentages of cognitive impairment. Delirium (with an odds ratio of (OR) 2.34, 95% CI 1.1–4.9, and p = 0.03) and the duration of mechanical ventilation (with an OR of 1.29, 95% CI 1.05–1.58, and p = 0.02) were independently identified as the risk factors for PICS in the first PICS survey. Conclusion: Approximately 60% of the ventilated patients with COVID-19 experienced persistent PICS, especially delirium, and required longer mechanical ventilation.
KW - COVID-19
KW - critically ill patients
KW - delirium
KW - post-intensive care syndrome
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U2 - 10.3390/jcm11195758
DO - 10.3390/jcm11195758
M3 - Article
AN - SCOPUS:85139904518
SN - 2077-0383
VL - 11
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 19
M1 - 5758
ER -