Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient

Enyu Imai, Masaru Horio, Kunitoshi Iseki, Kunihiro Yamagata, Tsuyoshi Watanabe, Shigeko Hara, Nobuyuki Ura, Yutaka Kiyohara, Hideki Hirakata, Toshiki Moriyama, Yasuhiro Ando, Kosaku Nitta, Daijo Inaguma, Ichiei Narita, Hiroyasu Iso, Kenji Wakai, Yoshinari Yasuda, Yusuke Tsukamoto, Sadayoshi Ito, Hirofumi MakinoAkira Hishida, Seiichi Matsuo

Research output: Contribution to journalArticle

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Abstract

Background. The number of patients with end-stage renal disease (ESRD) in Japan has continuously increased in the past three decades. In 2005, 36 063 patients whose average age was 66 years entered a new dialysis program. This large number of ESRD patients could be just the tip of the iceberg of an increasing number of patients with chronic kidney disease (CKD). However, to date, a nationwide epidemiological study has not been conducted yet to survey the CKD population. Methods. Data for 527 594 (male, 211 034; female, 316 560) participants were obtained from the general adult population aged over 20 years who received annual health check programs in 2000-2004, from seven different prefectures in Japan: Hokkaido, Fukushima, Ibaraki, Tokyo, Osaka, Fukuoka, and Okinawa prefectures. The glomerular filtration rate (GFR) for each participant was estimated from the serum creatinine values, using the abbreviated Modification of Diet in Renal Disease (MDRD) study equation modified by the Japanese coefficient. Results. The prevalences of CKD stage 3 in the study population, stratified by age groups of 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, and 80-89 years, were 1.4%, 3.6%, 10.8%, 15.9%, 31.8%, 44.0%, and 59.1%, respectively, predicting 19.1 million patients with stage 3 CKD in the Japanese general adult population of 103.2 million in 2004. CKD stage 4 + 5 was predicted in 200 000 patients in the Japanese general adult population. Comorbidity of hypertension, diabetes, and proteinuria increased as the estimated GFR (eGFR) decreased. The prevalence of concurrent CKD was significantly higher in hypertensive and diabetic populations than in the study population overall when CKD was defined as being present with an eGFR of less than 40 ml/min per 1.73 m2 instead of less than 60 ml/min per 1.73 m2. Conclusions. About 20% of the Japanese adult population (i.e., approximately 19 million people) are predicted to have stage 3 to 5 CKD, as defined by a GFR of less than 60 ml/min per 1.73 m2.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalClinical and Experimental Nephrology
Volume11
Issue number2
DOIs
Publication statusPublished - 01-06-2007

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Diet Therapy
Chronic Renal Insufficiency
Kidney
Population
Glomerular Filtration Rate
Chronic Kidney Failure
Japan
Tokyo
Proteinuria
Comorbidity
Epidemiologic Studies
Dialysis
Creatinine
Age Groups
Hypertension
Health

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Imai, Enyu ; Horio, Masaru ; Iseki, Kunitoshi ; Yamagata, Kunihiro ; Watanabe, Tsuyoshi ; Hara, Shigeko ; Ura, Nobuyuki ; Kiyohara, Yutaka ; Hirakata, Hideki ; Moriyama, Toshiki ; Ando, Yasuhiro ; Nitta, Kosaku ; Inaguma, Daijo ; Narita, Ichiei ; Iso, Hiroyasu ; Wakai, Kenji ; Yasuda, Yoshinari ; Tsukamoto, Yusuke ; Ito, Sadayoshi ; Makino, Hirofumi ; Hishida, Akira ; Matsuo, Seiichi. / Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient. In: Clinical and Experimental Nephrology. 2007 ; Vol. 11, No. 2. pp. 156-163.
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abstract = "Background. The number of patients with end-stage renal disease (ESRD) in Japan has continuously increased in the past three decades. In 2005, 36 063 patients whose average age was 66 years entered a new dialysis program. This large number of ESRD patients could be just the tip of the iceberg of an increasing number of patients with chronic kidney disease (CKD). However, to date, a nationwide epidemiological study has not been conducted yet to survey the CKD population. Methods. Data for 527 594 (male, 211 034; female, 316 560) participants were obtained from the general adult population aged over 20 years who received annual health check programs in 2000-2004, from seven different prefectures in Japan: Hokkaido, Fukushima, Ibaraki, Tokyo, Osaka, Fukuoka, and Okinawa prefectures. The glomerular filtration rate (GFR) for each participant was estimated from the serum creatinine values, using the abbreviated Modification of Diet in Renal Disease (MDRD) study equation modified by the Japanese coefficient. Results. The prevalences of CKD stage 3 in the study population, stratified by age groups of 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, and 80-89 years, were 1.4{\%}, 3.6{\%}, 10.8{\%}, 15.9{\%}, 31.8{\%}, 44.0{\%}, and 59.1{\%}, respectively, predicting 19.1 million patients with stage 3 CKD in the Japanese general adult population of 103.2 million in 2004. CKD stage 4 + 5 was predicted in 200 000 patients in the Japanese general adult population. Comorbidity of hypertension, diabetes, and proteinuria increased as the estimated GFR (eGFR) decreased. The prevalence of concurrent CKD was significantly higher in hypertensive and diabetic populations than in the study population overall when CKD was defined as being present with an eGFR of less than 40 ml/min per 1.73 m2 instead of less than 60 ml/min per 1.73 m2. Conclusions. About 20{\%} of the Japanese adult population (i.e., approximately 19 million people) are predicted to have stage 3 to 5 CKD, as defined by a GFR of less than 60 ml/min per 1.73 m2.",
author = "Enyu Imai and Masaru Horio and Kunitoshi Iseki and Kunihiro Yamagata and Tsuyoshi Watanabe and Shigeko Hara and Nobuyuki Ura and Yutaka Kiyohara and Hideki Hirakata and Toshiki Moriyama and Yasuhiro Ando and Kosaku Nitta and Daijo Inaguma and Ichiei Narita and Hiroyasu Iso and Kenji Wakai and Yoshinari Yasuda and Yusuke Tsukamoto and Sadayoshi Ito and Hirofumi Makino and Akira Hishida and Seiichi Matsuo",
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Imai, E, Horio, M, Iseki, K, Yamagata, K, Watanabe, T, Hara, S, Ura, N, Kiyohara, Y, Hirakata, H, Moriyama, T, Ando, Y, Nitta, K, Inaguma, D, Narita, I, Iso, H, Wakai, K, Yasuda, Y, Tsukamoto, Y, Ito, S, Makino, H, Hishida, A & Matsuo, S 2007, 'Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient', Clinical and Experimental Nephrology, vol. 11, no. 2, pp. 156-163. https://doi.org/10.1007/s10157-007-0463-x

Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient. / Imai, Enyu; Horio, Masaru; Iseki, Kunitoshi; Yamagata, Kunihiro; Watanabe, Tsuyoshi; Hara, Shigeko; Ura, Nobuyuki; Kiyohara, Yutaka; Hirakata, Hideki; Moriyama, Toshiki; Ando, Yasuhiro; Nitta, Kosaku; Inaguma, Daijo; Narita, Ichiei; Iso, Hiroyasu; Wakai, Kenji; Yasuda, Yoshinari; Tsukamoto, Yusuke; Ito, Sadayoshi; Makino, Hirofumi; Hishida, Akira; Matsuo, Seiichi.

In: Clinical and Experimental Nephrology, Vol. 11, No. 2, 01.06.2007, p. 156-163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient

AU - Imai, Enyu

AU - Horio, Masaru

AU - Iseki, Kunitoshi

AU - Yamagata, Kunihiro

AU - Watanabe, Tsuyoshi

AU - Hara, Shigeko

AU - Ura, Nobuyuki

AU - Kiyohara, Yutaka

AU - Hirakata, Hideki

AU - Moriyama, Toshiki

AU - Ando, Yasuhiro

AU - Nitta, Kosaku

AU - Inaguma, Daijo

AU - Narita, Ichiei

AU - Iso, Hiroyasu

AU - Wakai, Kenji

AU - Yasuda, Yoshinari

AU - Tsukamoto, Yusuke

AU - Ito, Sadayoshi

AU - Makino, Hirofumi

AU - Hishida, Akira

AU - Matsuo, Seiichi

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Background. The number of patients with end-stage renal disease (ESRD) in Japan has continuously increased in the past three decades. In 2005, 36 063 patients whose average age was 66 years entered a new dialysis program. This large number of ESRD patients could be just the tip of the iceberg of an increasing number of patients with chronic kidney disease (CKD). However, to date, a nationwide epidemiological study has not been conducted yet to survey the CKD population. Methods. Data for 527 594 (male, 211 034; female, 316 560) participants were obtained from the general adult population aged over 20 years who received annual health check programs in 2000-2004, from seven different prefectures in Japan: Hokkaido, Fukushima, Ibaraki, Tokyo, Osaka, Fukuoka, and Okinawa prefectures. The glomerular filtration rate (GFR) for each participant was estimated from the serum creatinine values, using the abbreviated Modification of Diet in Renal Disease (MDRD) study equation modified by the Japanese coefficient. Results. The prevalences of CKD stage 3 in the study population, stratified by age groups of 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, and 80-89 years, were 1.4%, 3.6%, 10.8%, 15.9%, 31.8%, 44.0%, and 59.1%, respectively, predicting 19.1 million patients with stage 3 CKD in the Japanese general adult population of 103.2 million in 2004. CKD stage 4 + 5 was predicted in 200 000 patients in the Japanese general adult population. Comorbidity of hypertension, diabetes, and proteinuria increased as the estimated GFR (eGFR) decreased. The prevalence of concurrent CKD was significantly higher in hypertensive and diabetic populations than in the study population overall when CKD was defined as being present with an eGFR of less than 40 ml/min per 1.73 m2 instead of less than 60 ml/min per 1.73 m2. Conclusions. About 20% of the Japanese adult population (i.e., approximately 19 million people) are predicted to have stage 3 to 5 CKD, as defined by a GFR of less than 60 ml/min per 1.73 m2.

AB - Background. The number of patients with end-stage renal disease (ESRD) in Japan has continuously increased in the past three decades. In 2005, 36 063 patients whose average age was 66 years entered a new dialysis program. This large number of ESRD patients could be just the tip of the iceberg of an increasing number of patients with chronic kidney disease (CKD). However, to date, a nationwide epidemiological study has not been conducted yet to survey the CKD population. Methods. Data for 527 594 (male, 211 034; female, 316 560) participants were obtained from the general adult population aged over 20 years who received annual health check programs in 2000-2004, from seven different prefectures in Japan: Hokkaido, Fukushima, Ibaraki, Tokyo, Osaka, Fukuoka, and Okinawa prefectures. The glomerular filtration rate (GFR) for each participant was estimated from the serum creatinine values, using the abbreviated Modification of Diet in Renal Disease (MDRD) study equation modified by the Japanese coefficient. Results. The prevalences of CKD stage 3 in the study population, stratified by age groups of 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, and 80-89 years, were 1.4%, 3.6%, 10.8%, 15.9%, 31.8%, 44.0%, and 59.1%, respectively, predicting 19.1 million patients with stage 3 CKD in the Japanese general adult population of 103.2 million in 2004. CKD stage 4 + 5 was predicted in 200 000 patients in the Japanese general adult population. Comorbidity of hypertension, diabetes, and proteinuria increased as the estimated GFR (eGFR) decreased. The prevalence of concurrent CKD was significantly higher in hypertensive and diabetic populations than in the study population overall when CKD was defined as being present with an eGFR of less than 40 ml/min per 1.73 m2 instead of less than 60 ml/min per 1.73 m2. Conclusions. About 20% of the Japanese adult population (i.e., approximately 19 million people) are predicted to have stage 3 to 5 CKD, as defined by a GFR of less than 60 ml/min per 1.73 m2.

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