TY - JOUR
T1 - Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes
AU - Wachino, Jun Ichi
AU - Yamane, Kunikazu
AU - Suzuki, Satowa
AU - Kimura, Kouji
AU - Arakawa, Yoshichika
PY - 2010/7
Y1 - 2010/7
N2 - We evaluated the in vitro activity of fosfomycin against a total of 192 CTX-M β-lactamase-producing Escherichia coli strains isolated in 70 Japanese clinical settings. Most of the isolates (96.4%) were found to be susceptible to fosfomycin. On the other hand, some of the resistant isolates were confirmed to harbor the novel transferable fosfomycin resistance determinants named FosA3 and FosC2, which efficaciously inactivate fosfomycin through glutathione S-transferase activity.
AB - We evaluated the in vitro activity of fosfomycin against a total of 192 CTX-M β-lactamase-producing Escherichia coli strains isolated in 70 Japanese clinical settings. Most of the isolates (96.4%) were found to be susceptible to fosfomycin. On the other hand, some of the resistant isolates were confirmed to harbor the novel transferable fosfomycin resistance determinants named FosA3 and FosC2, which efficaciously inactivate fosfomycin through glutathione S-transferase activity.
UR - http://www.scopus.com/inward/record.url?scp=77953738805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953738805&partnerID=8YFLogxK
U2 - 10.1128/AAC.01834-09
DO - 10.1128/AAC.01834-09
M3 - Article
C2 - 20404116
AN - SCOPUS:77953738805
SN - 0066-4804
VL - 54
SP - 3061
EP - 3064
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 7
ER -
