Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes

Jun Ichi Wachino; Kunikazu Yamane; Satowa Suzuki; Kouji Kimura; Yoshichika Arakawa

doi:10.1128/AAC.01834-09

Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes

Jun Ichi Wachino
, Kunikazu Yamane
, Satowa Suzuki
, Kouji Kimura
, Yoshichika Arakawa

Research output: Contribution to journal › Article › peer-review

148 Citations (Scopus)

Abstract

We evaluated the in vitro activity of fosfomycin against a total of 192 CTX-M β-lactamase-producing Escherichia coli strains isolated in 70 Japanese clinical settings. Most of the isolates (96.4%) were found to be susceptible to fosfomycin. On the other hand, some of the resistant isolates were confirmed to harbor the novel transferable fosfomycin resistance determinants named FosA3 and FosC2, which efficaciously inactivate fosfomycin through glutathione S-transferase activity.

Original language	English
Pages (from-to)	3061-3064
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	54
Issue number	7
DOIs	https://doi.org/10.1128/AAC.01834-09
Publication status	Published - 07-2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01834-09

Cite this

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title = "Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes",

abstract = "We evaluated the in vitro activity of fosfomycin against a total of 192 CTX-M β-lactamase-producing Escherichia coli strains isolated in 70 Japanese clinical settings. Most of the isolates (96.4\%) were found to be susceptible to fosfomycin. On the other hand, some of the resistant isolates were confirmed to harbor the novel transferable fosfomycin resistance determinants named FosA3 and FosC2, which efficaciously inactivate fosfomycin through glutathione S-transferase activity.",

author = "Wachino, \{Jun Ichi\} and Kunikazu Yamane and Satowa Suzuki and Kouji Kimura and Yoshichika Arakawa",

year = "2010",

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volume = "54",

pages = "3061--3064",

journal = "Antimicrobial agents and chemotherapy",

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publisher = "American Society for Microbiology",

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Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes. / Wachino, Jun Ichi; Yamane, Kunikazu; Suzuki, Satowa et al.
In: Antimicrobial agents and chemotherapy, Vol. 54, No. 7, 07.2010, p. 3061-3064.

Research output: Contribution to journal › Article › peer-review

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AU - Wachino, Jun Ichi

AU - Yamane, Kunikazu

AU - Suzuki, Satowa

AU - Kimura, Kouji

AU - Arakawa, Yoshichika

PY - 2010/7

Y1 - 2010/7

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AB - We evaluated the in vitro activity of fosfomycin against a total of 192 CTX-M β-lactamase-producing Escherichia coli strains isolated in 70 Japanese clinical settings. Most of the isolates (96.4%) were found to be susceptible to fosfomycin. On the other hand, some of the resistant isolates were confirmed to harbor the novel transferable fosfomycin resistance determinants named FosA3 and FosC2, which efficaciously inactivate fosfomycin through glutathione S-transferase activity.

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U2 - 10.1128/AAC.01834-09

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JO - Antimicrobial agents and chemotherapy

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ER -

Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes

Abstract

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All Science Journal Classification (ASJC) codes

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