Prevalence of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) in patients with interstitial pneumonia

Akira Shiraki; Morihide Ando; Joe Shindoh; Takashi Abe; Keiko Wakahara; Yasushi Makino; Toshiaki Asano; Harunori Nakashima; Tetsunari Hase; Kikuo Shigemitsu; Michiaki Horiba; Kaoru Shimokata

Prevalence of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) in patients with interstitial pneumonia

Akira Shiraki
, Morihide Ando
, Joe Shindoh
, Takashi Abe
, Keiko Wakahara
, Yasushi Makino
, Toshiaki Asano
, Harunori Nakashima
, Tetsunari Hase
, Kikuo Shigemitsu
, Michiaki Horiba
, Kaoru Shimokata

Research output: Contribution to journal › Article › peer-review

Abstract

Myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) is an autoantibody that is frequently found in patients with vasculitides. We encountered some MPO-ANCA positive patients with interstitial pneumonia who lacked vasculitides, but its meaning remains unclear. We measured MPO-ANCA titers in 69 patients with interstitial pneumonia (IP) who did not have collagen vascular diseases and observed their outcome. MPO-ANCA was positive in 5 patients and its prevalence was 7.2%. Patients with MPO-ANCA positive showed higher positivity in rheumatoid factor (RF) than patients with MPO-ANCA negative. The sensitivity and specificity of a combination of anti-nuclear antibody-negative and RF-positive were 80.0% and 87.7%, respectively. Two patients were accompanied by microscopic polyangiitis and the 3-year survival rate was 40% in all patients with MPO-ANCA. Measurement of MPO-ANCA titers in patients with IPs is meaningful for determining therapeutic strategy.

Original language	English
Pages (from-to)	921-926
Number of pages	6
Journal	Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume	45
Issue number	12
Publication status	Published - 12-2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

Cite this

Shiraki, A., Ando, M., Shindoh, J., Abe, T., Wakahara, K., Makino, Y., Asano, T., Nakashima, H., Hase, T., Shigemitsu, K., Horiba, M., & Shimokata, K. (2007). Prevalence of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) in patients with interstitial pneumonia. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 45(12), 921-926.

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title = "Prevalence of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) in patients with interstitial pneumonia",

abstract = "Myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) is an autoantibody that is frequently found in patients with vasculitides. We encountered some MPO-ANCA positive patients with interstitial pneumonia who lacked vasculitides, but its meaning remains unclear. We measured MPO-ANCA titers in 69 patients with interstitial pneumonia (IP) who did not have collagen vascular diseases and observed their outcome. MPO-ANCA was positive in 5 patients and its prevalence was 7.2\%. Patients with MPO-ANCA positive showed higher positivity in rheumatoid factor (RF) than patients with MPO-ANCA negative. The sensitivity and specificity of a combination of anti-nuclear antibody-negative and RF-positive were 80.0\% and 87.7\%, respectively. Two patients were accompanied by microscopic polyangiitis and the 3-year survival rate was 40\% in all patients with MPO-ANCA. Measurement of MPO-ANCA titers in patients with IPs is meaningful for determining therapeutic strategy.",

author = "Akira Shiraki and Morihide Ando and Joe Shindoh and Takashi Abe and Keiko Wakahara and Yasushi Makino and Toshiaki Asano and Harunori Nakashima and Tetsunari Hase and Kikuo Shigemitsu and Michiaki Horiba and Kaoru Shimokata",

year = "2007",

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volume = "45",

pages = "921--926",

journal = "Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society",

issn = "1343-3490",

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Shiraki, A, Ando, M, Shindoh, J, Abe, T, Wakahara, K, Makino, Y, Asano, T, Nakashima, H, Hase, T, Shigemitsu, K, Horiba, M & Shimokata, K 2007, 'Prevalence of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) in patients with interstitial pneumonia', Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, vol. 45, no. 12, pp. 921-926.

TY - JOUR

T1 - Prevalence of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) in patients with interstitial pneumonia

AU - Shiraki, Akira

AU - Ando, Morihide

AU - Shindoh, Joe

AU - Abe, Takashi

AU - Wakahara, Keiko

AU - Makino, Yasushi

AU - Asano, Toshiaki

AU - Nakashima, Harunori

AU - Hase, Tetsunari

AU - Shigemitsu, Kikuo

AU - Horiba, Michiaki

AU - Shimokata, Kaoru

PY - 2007/12

Y1 - 2007/12

N2 - Myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) is an autoantibody that is frequently found in patients with vasculitides. We encountered some MPO-ANCA positive patients with interstitial pneumonia who lacked vasculitides, but its meaning remains unclear. We measured MPO-ANCA titers in 69 patients with interstitial pneumonia (IP) who did not have collagen vascular diseases and observed their outcome. MPO-ANCA was positive in 5 patients and its prevalence was 7.2%. Patients with MPO-ANCA positive showed higher positivity in rheumatoid factor (RF) than patients with MPO-ANCA negative. The sensitivity and specificity of a combination of anti-nuclear antibody-negative and RF-positive were 80.0% and 87.7%, respectively. Two patients were accompanied by microscopic polyangiitis and the 3-year survival rate was 40% in all patients with MPO-ANCA. Measurement of MPO-ANCA titers in patients with IPs is meaningful for determining therapeutic strategy.

AB - Myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) is an autoantibody that is frequently found in patients with vasculitides. We encountered some MPO-ANCA positive patients with interstitial pneumonia who lacked vasculitides, but its meaning remains unclear. We measured MPO-ANCA titers in 69 patients with interstitial pneumonia (IP) who did not have collagen vascular diseases and observed their outcome. MPO-ANCA was positive in 5 patients and its prevalence was 7.2%. Patients with MPO-ANCA positive showed higher positivity in rheumatoid factor (RF) than patients with MPO-ANCA negative. The sensitivity and specificity of a combination of anti-nuclear antibody-negative and RF-positive were 80.0% and 87.7%, respectively. Two patients were accompanied by microscopic polyangiitis and the 3-year survival rate was 40% in all patients with MPO-ANCA. Measurement of MPO-ANCA titers in patients with IPs is meaningful for determining therapeutic strategy.

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JO - Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

JF - Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

IS - 12

ER -

Prevalence of myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) in patients with interstitial pneumonia

Abstract

All Science Journal Classification (ASJC) codes

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