Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis

Takuya Ishikawa, Kinichi Takeda, Masatsugu Itoh, Tadashi Imaizumi, Kenji Oguri, Hiroshi Takahashi, Hirotake Kasuga, Takanobu Toriyama, Seiichi Matsuo, Yoshiki Hirooka, Akihiro Itoh, Hiroki Kawashima, Toshifumi Kasugai, Eizaburo Ohno, Ryoji Miyahara, Masatoshi Ishigami, Yoshiaki Katano, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

OBJECTIVES: Pancreatic cystic (PC) lesions are not necessarily rare, and it is important to diagnose whether PC lesions are neoplastic such as intraductal papillary mucinous neoplasm (IPMN) because of its malignant potential. Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients. METHODS: We reviewed 1012 consecutive HD patients and 11,100 patients (controls) without renal disease who underwent transabdominal ultrasonography between January 2003 and December 2005. Patients' sex ratio (female-to-male) was less, and the age was older in HD patients. Clinical findings of these patients were examined. RESULTS: The prevalence both of PC lesions and IPMNs was significantly higher in HD patients than in controls (9.3% vs 1.3% and 2.8% vs 0.2%, P < 0.0001). The incidence of IPMNs in HD patients with PC lesions was higher than that in controls with PC lesions (29.8% vs 17.0%, P = 0.021). Multivariate logistic regression analysis revealed that the odds ratios of PC lesions and IPMNs were 6.38 (95% confidence interval, 4.82-8.45) and 9.39 (95% confidence interval, 5.36-16.49) in HD patients compared with controls. CONCLUSION:: The prevalence of PC lesions in HD patients is higher, and HD patients with PC lesions have high prevalence of IPMNs.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalPancreas
Volume38
Issue number2
DOIs
Publication statusPublished - 01-03-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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    Ishikawa, T., Takeda, K., Itoh, M., Imaizumi, T., Oguri, K., Takahashi, H., Kasuga, H., Toriyama, T., Matsuo, S., Hirooka, Y., Itoh, A., Kawashima, H., Kasugai, T., Ohno, E., Miyahara, R., Ishigami, M., Katano, Y., Ohmiya, N., Niwa, Y., & Goto, H. (2009). Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis. Pancreas, 38(2), 175-179. https://doi.org/10.1097/MPA.0b013e31818786c9