Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis

Takuya Ishikawa, Kinichi Takeda, Masatsugu Itoh, Tadashi Imaizumi, Kenji Oguri, Hiroshi Takahashi, Hirotake Kasuga, Takanobu Toriyama, Seiichi Matsuo, Yoshiki Hirooka, Akihiro Itoh, Hiroki Kawashima, Toshifumi Kasugai, Eizaburo Ohno, Ryoji Miyahara, Masatoshi Ishigami, Yoshiaki Katano, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVES: Pancreatic cystic (PC) lesions are not necessarily rare, and it is important to diagnose whether PC lesions are neoplastic such as intraductal papillary mucinous neoplasm (IPMN) because of its malignant potential. Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients. METHODS: We reviewed 1012 consecutive HD patients and 11,100 patients (controls) without renal disease who underwent transabdominal ultrasonography between January 2003 and December 2005. Patients' sex ratio (female-to-male) was less, and the age was older in HD patients. Clinical findings of these patients were examined. RESULTS: The prevalence both of PC lesions and IPMNs was significantly higher in HD patients than in controls (9.3% vs 1.3% and 2.8% vs 0.2%, P < 0.0001). The incidence of IPMNs in HD patients with PC lesions was higher than that in controls with PC lesions (29.8% vs 17.0%, P = 0.021). Multivariate logistic regression analysis revealed that the odds ratios of PC lesions and IPMNs were 6.38 (95% confidence interval, 4.82-8.45) and 9.39 (95% confidence interval, 5.36-16.49) in HD patients compared with controls. CONCLUSION:: The prevalence of PC lesions in HD patients is higher, and HD patients with PC lesions have high prevalence of IPMNs.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalPancreas
Volume38
Issue number2
DOIs
Publication statusPublished - 01-03-2009
Externally publishedYes

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Chronic Kidney Failure
Renal Dialysis
Neoplasms
Confidence Intervals
Sex Ratio
Ultrasonography
Logistic Models
Odds Ratio
Regression Analysis
Kidney
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Ishikawa, Takuya ; Takeda, Kinichi ; Itoh, Masatsugu ; Imaizumi, Tadashi ; Oguri, Kenji ; Takahashi, Hiroshi ; Kasuga, Hirotake ; Toriyama, Takanobu ; Matsuo, Seiichi ; Hirooka, Yoshiki ; Itoh, Akihiro ; Kawashima, Hiroki ; Kasugai, Toshifumi ; Ohno, Eizaburo ; Miyahara, Ryoji ; Ishigami, Masatoshi ; Katano, Yoshiaki ; Ohmiya, Naoki ; Niwa, Yasumasa ; Goto, Hidemi. / Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis. In: Pancreas. 2009 ; Vol. 38, No. 2. pp. 175-179.
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title = "Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis",
abstract = "OBJECTIVES: Pancreatic cystic (PC) lesions are not necessarily rare, and it is important to diagnose whether PC lesions are neoplastic such as intraductal papillary mucinous neoplasm (IPMN) because of its malignant potential. Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients. METHODS: We reviewed 1012 consecutive HD patients and 11,100 patients (controls) without renal disease who underwent transabdominal ultrasonography between January 2003 and December 2005. Patients' sex ratio (female-to-male) was less, and the age was older in HD patients. Clinical findings of these patients were examined. RESULTS: The prevalence both of PC lesions and IPMNs was significantly higher in HD patients than in controls (9.3{\%} vs 1.3{\%} and 2.8{\%} vs 0.2{\%}, P < 0.0001). The incidence of IPMNs in HD patients with PC lesions was higher than that in controls with PC lesions (29.8{\%} vs 17.0{\%}, P = 0.021). Multivariate logistic regression analysis revealed that the odds ratios of PC lesions and IPMNs were 6.38 (95{\%} confidence interval, 4.82-8.45) and 9.39 (95{\%} confidence interval, 5.36-16.49) in HD patients compared with controls. CONCLUSION:: The prevalence of PC lesions in HD patients is higher, and HD patients with PC lesions have high prevalence of IPMNs.",
author = "Takuya Ishikawa and Kinichi Takeda and Masatsugu Itoh and Tadashi Imaizumi and Kenji Oguri and Hiroshi Takahashi and Hirotake Kasuga and Takanobu Toriyama and Seiichi Matsuo and Yoshiki Hirooka and Akihiro Itoh and Hiroki Kawashima and Toshifumi Kasugai and Eizaburo Ohno and Ryoji Miyahara and Masatoshi Ishigami and Yoshiaki Katano and Naoki Ohmiya and Yasumasa Niwa and Hidemi Goto",
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Ishikawa, T, Takeda, K, Itoh, M, Imaizumi, T, Oguri, K, Takahashi, H, Kasuga, H, Toriyama, T, Matsuo, S, Hirooka, Y, Itoh, A, Kawashima, H, Kasugai, T, Ohno, E, Miyahara, R, Ishigami, M, Katano, Y, Ohmiya, N, Niwa, Y & Goto, H 2009, 'Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis', Pancreas, vol. 38, no. 2, pp. 175-179. https://doi.org/10.1097/MPA.0b013e31818786c9

Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis. / Ishikawa, Takuya; Takeda, Kinichi; Itoh, Masatsugu; Imaizumi, Tadashi; Oguri, Kenji; Takahashi, Hiroshi; Kasuga, Hirotake; Toriyama, Takanobu; Matsuo, Seiichi; Hirooka, Yoshiki; Itoh, Akihiro; Kawashima, Hiroki; Kasugai, Toshifumi; Ohno, Eizaburo; Miyahara, Ryoji; Ishigami, Masatoshi; Katano, Yoshiaki; Ohmiya, Naoki; Niwa, Yasumasa; Goto, Hidemi.

In: Pancreas, Vol. 38, No. 2, 01.03.2009, p. 175-179.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis

AU - Ishikawa, Takuya

AU - Takeda, Kinichi

AU - Itoh, Masatsugu

AU - Imaizumi, Tadashi

AU - Oguri, Kenji

AU - Takahashi, Hiroshi

AU - Kasuga, Hirotake

AU - Toriyama, Takanobu

AU - Matsuo, Seiichi

AU - Hirooka, Yoshiki

AU - Itoh, Akihiro

AU - Kawashima, Hiroki

AU - Kasugai, Toshifumi

AU - Ohno, Eizaburo

AU - Miyahara, Ryoji

AU - Ishigami, Masatoshi

AU - Katano, Yoshiaki

AU - Ohmiya, Naoki

AU - Niwa, Yasumasa

AU - Goto, Hidemi

PY - 2009/3/1

Y1 - 2009/3/1

N2 - OBJECTIVES: Pancreatic cystic (PC) lesions are not necessarily rare, and it is important to diagnose whether PC lesions are neoplastic such as intraductal papillary mucinous neoplasm (IPMN) because of its malignant potential. Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients. METHODS: We reviewed 1012 consecutive HD patients and 11,100 patients (controls) without renal disease who underwent transabdominal ultrasonography between January 2003 and December 2005. Patients' sex ratio (female-to-male) was less, and the age was older in HD patients. Clinical findings of these patients were examined. RESULTS: The prevalence both of PC lesions and IPMNs was significantly higher in HD patients than in controls (9.3% vs 1.3% and 2.8% vs 0.2%, P < 0.0001). The incidence of IPMNs in HD patients with PC lesions was higher than that in controls with PC lesions (29.8% vs 17.0%, P = 0.021). Multivariate logistic regression analysis revealed that the odds ratios of PC lesions and IPMNs were 6.38 (95% confidence interval, 4.82-8.45) and 9.39 (95% confidence interval, 5.36-16.49) in HD patients compared with controls. CONCLUSION:: The prevalence of PC lesions in HD patients is higher, and HD patients with PC lesions have high prevalence of IPMNs.

AB - OBJECTIVES: Pancreatic cystic (PC) lesions are not necessarily rare, and it is important to diagnose whether PC lesions are neoplastic such as intraductal papillary mucinous neoplasm (IPMN) because of its malignant potential. Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients. METHODS: We reviewed 1012 consecutive HD patients and 11,100 patients (controls) without renal disease who underwent transabdominal ultrasonography between January 2003 and December 2005. Patients' sex ratio (female-to-male) was less, and the age was older in HD patients. Clinical findings of these patients were examined. RESULTS: The prevalence both of PC lesions and IPMNs was significantly higher in HD patients than in controls (9.3% vs 1.3% and 2.8% vs 0.2%, P < 0.0001). The incidence of IPMNs in HD patients with PC lesions was higher than that in controls with PC lesions (29.8% vs 17.0%, P = 0.021). Multivariate logistic regression analysis revealed that the odds ratios of PC lesions and IPMNs were 6.38 (95% confidence interval, 4.82-8.45) and 9.39 (95% confidence interval, 5.36-16.49) in HD patients compared with controls. CONCLUSION:: The prevalence of PC lesions in HD patients is higher, and HD patients with PC lesions have high prevalence of IPMNs.

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U2 - 10.1097/MPA.0b013e31818786c9

DO - 10.1097/MPA.0b013e31818786c9

M3 - Article

C2 - 18824946

AN - SCOPUS:65349146428

VL - 38

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JO - Pancreas

JF - Pancreas

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