Prevention of oxaliplatin-related neurotoxicity by glutathione infusions

Norio Takimoto, Shiho Sugawara, Akiko Iida, Takashi Sakakibara, Kenji Mori, Mitsuru Sugiura, Minoru Yamamoto, Moritsugu Tanaka, Tetsushi Hayakawa, Keiko Yamamura, Mamoru Adachi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We have used glutathione for prevention of oxaliplatin-related neurotoxicity with reference to the article of Cascinu et al. We investigated oxaliplatin-related neurotoxicity in Kariya Toyota General Hospital(KTGH)and compared with the data described in the article of Gamelin about the severity of its neurotoxicity. Grade 3 neurotoxicity was observed in only 5 of 44 patients(11.4%). The median number of cycles and cumulative dose of oxaliplatin were 12 cycles(5-27 / cycles)and 802.2(273.2-1,952.4)mg/m(2), respectively, at Grade 3 neuropathy. We evaluated retrospectively neuro-toxicity grade at cumulative oxaliplatin doses of approximately 500-520 mg/m(2). The severity of neurotoxicity observed in KTGH was significantly lower than in the group without Ca/Mg. We found no difference between the group with glutathione and / with Ca/Mg. Glutathione infusions seemed to prevent oxaliplatin-related neurotoxicity.

Original languageEnglish
Pages (from-to)2373-2376
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume35
Issue number13
Publication statusPublished - 12-2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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