Prevention of oxaliplatin-related neurotoxicity by glutathione infusions

Norio Takimoto; Shiho Sugawara; Akiko Iida; Takashi Sakakibara; Kenji Mori; Mitsuru Sugiura; Minoru Yamamoto; Moritsugu Tanaka; Tetsushi Hayakawa; Keiko Yamamura; Mamoru Adachi

Prevention of oxaliplatin-related neurotoxicity by glutathione infusions

Norio Takimoto, Shiho Sugawara, Akiko Iida, Takashi Sakakibara, Kenji Mori, Mitsuru Sugiura, Minoru Yamamoto, Moritsugu Tanaka, Tetsushi Hayakawa, Keiko Yamamura, Mamoru Adachi

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We have used glutathione for prevention of oxaliplatin-related neurotoxicity with reference to the article of Cascinu et al. We investigated oxaliplatin-related neurotoxicity in Kariya Toyota General Hospital(KTGH)and compared with the data described in the article of Gamelin about the severity of its neurotoxicity. Grade 3 neurotoxicity was observed in only 5 of 44 patients(11.4%). The median number of cycles and cumulative dose of oxaliplatin were 12 cycles(5-27 / cycles)and 802.2(273.2-1,952.4)mg/m(2), respectively, at Grade 3 neuropathy. We evaluated retrospectively neuro-toxicity grade at cumulative oxaliplatin doses of approximately 500-520 mg/m(2). The severity of neurotoxicity observed in KTGH was significantly lower than in the group without Ca/Mg. We found no difference between the group with glutathione and / with Ca/Mg. Glutathione infusions seemed to prevent oxaliplatin-related neurotoxicity.

Original language	English
Pages (from-to)	2373-2376
Number of pages	4
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
Volume	35
Issue number	13
Publication status	Published - 12-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

Cite this

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title = "Prevention of oxaliplatin-related neurotoxicity by glutathione infusions",

abstract = "We have used glutathione for prevention of oxaliplatin-related neurotoxicity with reference to the article of Cascinu et al. We investigated oxaliplatin-related neurotoxicity in Kariya Toyota General Hospital(KTGH)and compared with the data described in the article of Gamelin about the severity of its neurotoxicity. Grade 3 neurotoxicity was observed in only 5 of 44 patients(11.4%). The median number of cycles and cumulative dose of oxaliplatin were 12 cycles(5-27 / cycles)and 802.2(273.2-1,952.4)mg/m(2), respectively, at Grade 3 neuropathy. We evaluated retrospectively neuro-toxicity grade at cumulative oxaliplatin doses of approximately 500-520 mg/m(2). The severity of neurotoxicity observed in KTGH was significantly lower than in the group without Ca/Mg. We found no difference between the group with glutathione and / with Ca/Mg. Glutathione infusions seemed to prevent oxaliplatin-related neurotoxicity.",

author = "Norio Takimoto and Shiho Sugawara and Akiko Iida and Takashi Sakakibara and Kenji Mori and Mitsuru Sugiura and Minoru Yamamoto and Moritsugu Tanaka and Tetsushi Hayakawa and Keiko Yamamura and Mamoru Adachi",

year = "2008",

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language = "English",

volume = "35",

pages = "2373--2376",

journal = "Gan to kagaku ryoho. Cancer & chemotherapy",

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publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

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T1 - Prevention of oxaliplatin-related neurotoxicity by glutathione infusions

AU - Takimoto, Norio

AU - Sugawara, Shiho

AU - Iida, Akiko

AU - Sakakibara, Takashi

AU - Mori, Kenji

AU - Sugiura, Mitsuru

AU - Yamamoto, Minoru

AU - Tanaka, Moritsugu

AU - Hayakawa, Tetsushi

AU - Yamamura, Keiko

AU - Adachi, Mamoru

PY - 2008/12

Y1 - 2008/12

N2 - We have used glutathione for prevention of oxaliplatin-related neurotoxicity with reference to the article of Cascinu et al. We investigated oxaliplatin-related neurotoxicity in Kariya Toyota General Hospital(KTGH)and compared with the data described in the article of Gamelin about the severity of its neurotoxicity. Grade 3 neurotoxicity was observed in only 5 of 44 patients(11.4%). The median number of cycles and cumulative dose of oxaliplatin were 12 cycles(5-27 / cycles)and 802.2(273.2-1,952.4)mg/m(2), respectively, at Grade 3 neuropathy. We evaluated retrospectively neuro-toxicity grade at cumulative oxaliplatin doses of approximately 500-520 mg/m(2). The severity of neurotoxicity observed in KTGH was significantly lower than in the group without Ca/Mg. We found no difference between the group with glutathione and / with Ca/Mg. Glutathione infusions seemed to prevent oxaliplatin-related neurotoxicity.

AB - We have used glutathione for prevention of oxaliplatin-related neurotoxicity with reference to the article of Cascinu et al. We investigated oxaliplatin-related neurotoxicity in Kariya Toyota General Hospital(KTGH)and compared with the data described in the article of Gamelin about the severity of its neurotoxicity. Grade 3 neurotoxicity was observed in only 5 of 44 patients(11.4%). The median number of cycles and cumulative dose of oxaliplatin were 12 cycles(5-27 / cycles)and 802.2(273.2-1,952.4)mg/m(2), respectively, at Grade 3 neuropathy. We evaluated retrospectively neuro-toxicity grade at cumulative oxaliplatin doses of approximately 500-520 mg/m(2). The severity of neurotoxicity observed in KTGH was significantly lower than in the group without Ca/Mg. We found no difference between the group with glutathione and / with Ca/Mg. Glutathione infusions seemed to prevent oxaliplatin-related neurotoxicity.

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SN - 0385-0684

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JO - Gan to kagaku ryoho. Cancer & chemotherapy

JF - Gan to kagaku ryoho. Cancer & chemotherapy

IS - 13

ER -

Prevention of oxaliplatin-related neurotoxicity by glutathione infusions

Abstract

All Science Journal Classification (ASJC) codes

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