TY - JOUR
T1 - Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats
AU - Ohta, Yoshiji
AU - Kobayashi, Takashi
AU - Inui, Kazuo
AU - Yoshino, Junji
AU - Kitagawa, Akira
AU - Nakazawa, Saburo
PY - 2004/3/8
Y1 - 2004/3/8
N2 - The preventive effect of teprenone (6,10,14,18-teramethyl-5,9,13,17- nonadecatetaene-2-one), an anti-ulcer drug, on acute gastric mucosal lesion progression was examined in rats with a single intraperitoneal (i.p.) injection of compound 48/80 (0.75 mg/kg). Teprenone (20, 100 or 200 mg/kg), which was orally administered 0.5 h after compound 48/80 treatment at which time gastric mucosal lesions appeared, prevented gastric mucosal lesion development at 3 h after the treatment dose-dependently. Gastric mucosal tissues of compound 48/80-treated rats showed increases in myeloperoxidase (an index of neutrophil infiltration) and xanthine oxidase activities and thiobarbituric acid reactive substances (an index of lipid peroxidation) content and decreases in Se-glutathione peroxidase activity and hexosamine and vitamin E contents at 3 h after the treatment. Post-administered teprenone attenuated all these changes dose-dependently. These results indicate that teprenone prevents acute gastric mucosal lesion progression in compound 48/80-treated rats possibly by suppressing gastric mucus depletion, neutrophil infiltration and oxidative stress in the gastric mucosal tissue.
AB - The preventive effect of teprenone (6,10,14,18-teramethyl-5,9,13,17- nonadecatetaene-2-one), an anti-ulcer drug, on acute gastric mucosal lesion progression was examined in rats with a single intraperitoneal (i.p.) injection of compound 48/80 (0.75 mg/kg). Teprenone (20, 100 or 200 mg/kg), which was orally administered 0.5 h after compound 48/80 treatment at which time gastric mucosal lesions appeared, prevented gastric mucosal lesion development at 3 h after the treatment dose-dependently. Gastric mucosal tissues of compound 48/80-treated rats showed increases in myeloperoxidase (an index of neutrophil infiltration) and xanthine oxidase activities and thiobarbituric acid reactive substances (an index of lipid peroxidation) content and decreases in Se-glutathione peroxidase activity and hexosamine and vitamin E contents at 3 h after the treatment. Post-administered teprenone attenuated all these changes dose-dependently. These results indicate that teprenone prevents acute gastric mucosal lesion progression in compound 48/80-treated rats possibly by suppressing gastric mucus depletion, neutrophil infiltration and oxidative stress in the gastric mucosal tissue.
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U2 - 10.1016/j.ejphar.2004.01.032
DO - 10.1016/j.ejphar.2004.01.032
M3 - Article
C2 - 15033395
AN - SCOPUS:1642395753
SN - 0014-2999
VL - 487
SP - 223
EP - 232
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -