Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats

Yoshiji Ohta, Takashi Kobayashi, Kazuo Inui, Junji Yoshino, Akira Kitagawa, Saburo Nakazawa

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The preventive effect of teprenone (6,10,14,18-teramethyl-5,9,13,17- nonadecatetaene-2-one), an anti-ulcer drug, on acute gastric mucosal lesion progression was examined in rats with a single intraperitoneal (i.p.) injection of compound 48/80 (0.75 mg/kg). Teprenone (20, 100 or 200 mg/kg), which was orally administered 0.5 h after compound 48/80 treatment at which time gastric mucosal lesions appeared, prevented gastric mucosal lesion development at 3 h after the treatment dose-dependently. Gastric mucosal tissues of compound 48/80-treated rats showed increases in myeloperoxidase (an index of neutrophil infiltration) and xanthine oxidase activities and thiobarbituric acid reactive substances (an index of lipid peroxidation) content and decreases in Se-glutathione peroxidase activity and hexosamine and vitamin E contents at 3 h after the treatment. Post-administered teprenone attenuated all these changes dose-dependently. These results indicate that teprenone prevents acute gastric mucosal lesion progression in compound 48/80-treated rats possibly by suppressing gastric mucus depletion, neutrophil infiltration and oxidative stress in the gastric mucosal tissue.

Original languageEnglish
Pages (from-to)223-232
Number of pages10
JournalEuropean Journal of Pharmacology
Volume487
Issue number1-3
DOIs
Publication statusPublished - 08-03-2004

All Science Journal Classification (ASJC) codes

  • Pharmacology

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