Preventive effects of risedronate and calcitriol on cancellous osteopenia in rats treated with high-dose glucocorticoid

Jun Iwamoto, Azusa Seki, Tsuyoshi Takeda, Yoshihiro Sato, Harumoto Yamada, Chwan Li Shen, James K. Yeh

Research output: Contribution to journalArticle

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Abstract

We compared the effects of risedronate (Ris) and calcitriol (Cal) on cancellous osteopenia in rats treated with high-dose glucocorticoid (GC). Forty female Sprague-Dawley rats, 4 months of age, were randomized by the stratified weight method into four groups of 10 rats each according to the following treatment schedule: intact control, and GC administration with vehicle, Ris, or Cal. The GC (methylprednisolone sodium succinate, 5.0 mg/kg, s.c.), Ris.(10 μg/kg, s.c.), and Cal (0.1 μg/kg, p.o.) were administered 3 times a week. At the end of the 4-week treatment period, bone histomorphometric analysis was performed for cancellous bone of the proximal tibial metaphysis. The GC administration decreased cancellous bone volume (BV/total tissue volume [TV]), trabecular number (Tb N), and trabecuiar thickness (Tb Th), as a result of increased bone resorption and decreased bone formation. Ris treatment markedly increased cancellous BV/TV and Tb N above the control level as a result of suppressed bone turnover. On the other hand, Cal treatment attenuated the GC-induced decrease in cancellous BV/TV and Tb Th as a result of suppressed bone resorption and maintained bone formation. This study showed the differential effects of Ris and Cal on cancellous osteopenia in rats treated with high-dose GC.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalExperimental Animals
Volume55
Issue number4
DOIs
Publication statusPublished - 01-08-2006

Fingerprint

osteopenia
calcitriol
Calcitriol
Metabolic Bone Diseases
glucocorticoids
Glucocorticoids
Rats
Bone
rats
dosage
bones
bone resorption
Bone Resorption
bone formation
Osteogenesis
Tissue
Methylprednisolone Hemisuccinate
Bone Remodeling
succinic acid
Sprague Dawley Rats

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Iwamoto, Jun ; Seki, Azusa ; Takeda, Tsuyoshi ; Sato, Yoshihiro ; Yamada, Harumoto ; Shen, Chwan Li ; Yeh, James K. / Preventive effects of risedronate and calcitriol on cancellous osteopenia in rats treated with high-dose glucocorticoid. In: Experimental Animals. 2006 ; Vol. 55, No. 4. pp. 349-355.
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Preventive effects of risedronate and calcitriol on cancellous osteopenia in rats treated with high-dose glucocorticoid. / Iwamoto, Jun; Seki, Azusa; Takeda, Tsuyoshi; Sato, Yoshihiro; Yamada, Harumoto; Shen, Chwan Li; Yeh, James K.

In: Experimental Animals, Vol. 55, No. 4, 01.08.2006, p. 349-355.

Research output: Contribution to journalArticle

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T1 - Preventive effects of risedronate and calcitriol on cancellous osteopenia in rats treated with high-dose glucocorticoid

AU - Iwamoto, Jun

AU - Seki, Azusa

AU - Takeda, Tsuyoshi

AU - Sato, Yoshihiro

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AU - Yeh, James K.

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