TY - JOUR
T1 - Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity
T2 - A multicenter, retrospective analysis in Japan
AU - Takata, Katsuyoshi
AU - Okada, Hiroyuki
AU - Ohmiya, Naoki
AU - Nakamura, Shotaro
AU - Kitadai, Yasuhiko
AU - Tari, Akira
AU - Akamatsu, Taiji
AU - Kawai, Hiroki
AU - Tanaka, Shu
AU - Araki, Hiroshi
AU - Yoshida, Takashi
AU - Okumura, Hirokazu
AU - Nishisaki, Hogara
AU - Sagawa, Tamotsu
AU - Watanabe, Norihiko
AU - Arima, Nobuyoshi
AU - Takatsu, Noritaka
AU - Nakamura, Masanao
AU - Yanai, Shunichi
AU - Kaya, Hiroyasu
AU - Morito, Toshiaki
AU - Sato, Yasuharu
AU - Moriwaki, Hisataka
AU - Sakamoto, Choitsu
AU - Niwa, Yasumasa
AU - Goto, Hidemi
AU - Chiba, Tsutomu
AU - Matsumoto, Takayuki
AU - Ennishi, Daisuke
AU - Kinoshita, Tomohiro
AU - Yoshino, Tadashi
PY - 2011/8
Y1 - 2011/8
N2 - We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI-FL. Of the 125 patients, the small intestine was examined in 70 patients, with double-balloon endoscopy and/or capsule endoscopy. The most frequently involved GI-FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP-positive group. During a median follow up of 40months, six patients showed disease progression. Patients with involvement of the DSP had better progression-free survival (PFS) than those without such involvement (P=0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI-FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course.
AB - We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI-FL. Of the 125 patients, the small intestine was examined in 70 patients, with double-balloon endoscopy and/or capsule endoscopy. The most frequently involved GI-FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP-positive group. During a median follow up of 40months, six patients showed disease progression. Patients with involvement of the DSP had better progression-free survival (PFS) than those without such involvement (P=0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI-FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course.
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U2 - 10.1111/j.1349-7006.2011.01980.x
DO - 10.1111/j.1349-7006.2011.01980.x
M3 - Article
C2 - 21561531
AN - SCOPUS:79960385339
SN - 1347-9032
VL - 102
SP - 1532
EP - 1536
JO - Cancer science
JF - Cancer science
IS - 8
ER -
