Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity

A multicenter, retrospective analysis in Japan

Katsuyoshi Takata, Hiroyuki Okada, Naoki Omiya, Shotaro Nakamura, Yasuhiko Kitadai, Akira Tari, Taiji Akamatsu, Hiroki Kawai, Shu Tanaka, Hiroshi Araki, Takashi Yoshida, Hirokazu Okumura, Hogara Nishisaki, Tamotsu Sagawa, Norihiko Watanabe, Nobuyoshi Arima, Noritaka Takatsu, Masanao Nakamura, Shunichi Yanai, Hiroyasu Kaya & 11 others Toshiaki Morito, Yasuharu Sato, Hisataka Moriwaki, Choitsu Sakamoto, Yasumasa Niwa, Hidemi Goto, Tsutomu Chiba, Takayuki Matsumoto, Daisuke Ennishi, Tomohiro Kinoshita, Tadashi Yoshino

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI-FL. Of the 125 patients, the small intestine was examined in 70 patients, with double-balloon endoscopy and/or capsule endoscopy. The most frequently involved GI-FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP-positive group. During a median follow up of 40months, six patients showed disease progression. Patients with involvement of the DSP had better progression-free survival (PFS) than those without such involvement (P=0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI-FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course.

Original languageEnglish
Pages (from-to)1532-1536
Number of pages5
JournalCancer Science
Volume102
Issue number8
DOIs
Publication statusPublished - 01-08-2011
Externally publishedYes

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Follicular Lymphoma
Japan
Disease-Free Survival
Capsule Endoscopy
Jejunum
Endoscopy
Multicenter Studies
Small Intestine
Disease Progression
Multivariate Analysis
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Takata, Katsuyoshi ; Okada, Hiroyuki ; Omiya, Naoki ; Nakamura, Shotaro ; Kitadai, Yasuhiko ; Tari, Akira ; Akamatsu, Taiji ; Kawai, Hiroki ; Tanaka, Shu ; Araki, Hiroshi ; Yoshida, Takashi ; Okumura, Hirokazu ; Nishisaki, Hogara ; Sagawa, Tamotsu ; Watanabe, Norihiko ; Arima, Nobuyoshi ; Takatsu, Noritaka ; Nakamura, Masanao ; Yanai, Shunichi ; Kaya, Hiroyasu ; Morito, Toshiaki ; Sato, Yasuharu ; Moriwaki, Hisataka ; Sakamoto, Choitsu ; Niwa, Yasumasa ; Goto, Hidemi ; Chiba, Tsutomu ; Matsumoto, Takayuki ; Ennishi, Daisuke ; Kinoshita, Tomohiro ; Yoshino, Tadashi. / Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity : A multicenter, retrospective analysis in Japan. In: Cancer Science. 2011 ; Vol. 102, No. 8. pp. 1532-1536.
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abstract = "We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI-FL. Of the 125 patients, the small intestine was examined in 70 patients, with double-balloon endoscopy and/or capsule endoscopy. The most frequently involved GI-FL site was the duodenal second portion (DSP) (81{\%}), followed by the jejunum (40{\%}); 85{\%} of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP-positive group. During a median follow up of 40months, six patients showed disease progression. Patients with involvement of the DSP had better progression-free survival (PFS) than those without such involvement (P=0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI-FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course.",
author = "Katsuyoshi Takata and Hiroyuki Okada and Naoki Omiya and Shotaro Nakamura and Yasuhiko Kitadai and Akira Tari and Taiji Akamatsu and Hiroki Kawai and Shu Tanaka and Hiroshi Araki and Takashi Yoshida and Hirokazu Okumura and Hogara Nishisaki and Tamotsu Sagawa and Norihiko Watanabe and Nobuyoshi Arima and Noritaka Takatsu and Masanao Nakamura and Shunichi Yanai and Hiroyasu Kaya and Toshiaki Morito and Yasuharu Sato and Hisataka Moriwaki and Choitsu Sakamoto and Yasumasa Niwa and Hidemi Goto and Tsutomu Chiba and Takayuki Matsumoto and Daisuke Ennishi and Tomohiro Kinoshita and Tadashi Yoshino",
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Takata, K, Okada, H, Omiya, N, Nakamura, S, Kitadai, Y, Tari, A, Akamatsu, T, Kawai, H, Tanaka, S, Araki, H, Yoshida, T, Okumura, H, Nishisaki, H, Sagawa, T, Watanabe, N, Arima, N, Takatsu, N, Nakamura, M, Yanai, S, Kaya, H, Morito, T, Sato, Y, Moriwaki, H, Sakamoto, C, Niwa, Y, Goto, H, Chiba, T, Matsumoto, T, Ennishi, D, Kinoshita, T & Yoshino, T 2011, 'Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: A multicenter, retrospective analysis in Japan', Cancer Science, vol. 102, no. 8, pp. 1532-1536. https://doi.org/10.1111/j.1349-7006.2011.01980.x

Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity : A multicenter, retrospective analysis in Japan. / Takata, Katsuyoshi; Okada, Hiroyuki; Omiya, Naoki; Nakamura, Shotaro; Kitadai, Yasuhiko; Tari, Akira; Akamatsu, Taiji; Kawai, Hiroki; Tanaka, Shu; Araki, Hiroshi; Yoshida, Takashi; Okumura, Hirokazu; Nishisaki, Hogara; Sagawa, Tamotsu; Watanabe, Norihiko; Arima, Nobuyoshi; Takatsu, Noritaka; Nakamura, Masanao; Yanai, Shunichi; Kaya, Hiroyasu; Morito, Toshiaki; Sato, Yasuharu; Moriwaki, Hisataka; Sakamoto, Choitsu; Niwa, Yasumasa; Goto, Hidemi; Chiba, Tsutomu; Matsumoto, Takayuki; Ennishi, Daisuke; Kinoshita, Tomohiro; Yoshino, Tadashi.

In: Cancer Science, Vol. 102, No. 8, 01.08.2011, p. 1532-1536.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity

T2 - A multicenter, retrospective analysis in Japan

AU - Takata, Katsuyoshi

AU - Okada, Hiroyuki

AU - Omiya, Naoki

AU - Nakamura, Shotaro

AU - Kitadai, Yasuhiko

AU - Tari, Akira

AU - Akamatsu, Taiji

AU - Kawai, Hiroki

AU - Tanaka, Shu

AU - Araki, Hiroshi

AU - Yoshida, Takashi

AU - Okumura, Hirokazu

AU - Nishisaki, Hogara

AU - Sagawa, Tamotsu

AU - Watanabe, Norihiko

AU - Arima, Nobuyoshi

AU - Takatsu, Noritaka

AU - Nakamura, Masanao

AU - Yanai, Shunichi

AU - Kaya, Hiroyasu

AU - Morito, Toshiaki

AU - Sato, Yasuharu

AU - Moriwaki, Hisataka

AU - Sakamoto, Choitsu

AU - Niwa, Yasumasa

AU - Goto, Hidemi

AU - Chiba, Tsutomu

AU - Matsumoto, Takayuki

AU - Ennishi, Daisuke

AU - Kinoshita, Tomohiro

AU - Yoshino, Tadashi

PY - 2011/8/1

Y1 - 2011/8/1

N2 - We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI-FL. Of the 125 patients, the small intestine was examined in 70 patients, with double-balloon endoscopy and/or capsule endoscopy. The most frequently involved GI-FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP-positive group. During a median follow up of 40months, six patients showed disease progression. Patients with involvement of the DSP had better progression-free survival (PFS) than those without such involvement (P=0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI-FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course.

AB - We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI-FL. Of the 125 patients, the small intestine was examined in 70 patients, with double-balloon endoscopy and/or capsule endoscopy. The most frequently involved GI-FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP-positive group. During a median follow up of 40months, six patients showed disease progression. Patients with involvement of the DSP had better progression-free survival (PFS) than those without such involvement (P=0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI-FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course.

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U2 - 10.1111/j.1349-7006.2011.01980.x

DO - 10.1111/j.1349-7006.2011.01980.x

M3 - Article

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SP - 1532

EP - 1536

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

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