Primary human herpesvirus 6 infection in liver transplant recipients

Tetsushi Yoshikawa, Masaru Ihira, Kyoko Suzuki, Sadao Suga, Yoshizo Asano, Katsuhiro Asonuma, Koichi Tanaka, Yukihiro Nishiyama

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We detected primary human herpesvirus 6 (HHV-6) infection in 5 infants who received living related liver transplantation from their HHV-6 seropositive mothers. Primary HHV-6 infection was confirmed by demonstrating the seroconversion of HHV-6 antibodies with an immunofluorescence assay, by the isolation of the virus, or both. Seroconversion of HHV-6 immunoglobulin G antibody was demonstrated in all 5 recipients. HHV-6 was isolated from 3 of the 5 recipients between 2 and 3 weeks after transplantation. Moreover, the virus genome was detected in plasma by polymerase chain reaction in 4 of the 5 recipients during the same period. Although the 5 recipients had pyrexia at the time of primary HHV-6 infection, none of the recipients had a skin rash after defervescence. Clinical symptoms disappeared without specific antiviral treatment in all but 1 of the recipients.

Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalJournal of Pediatrics
Volume138
Issue number6
DOIs
Publication statusPublished - 01-01-2001

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Human Herpesvirus 6
Herpesviridae Infections
Liver
Viruses
Antibodies
Transplant Recipients
Exanthema
Liver Transplantation
Antiviral Agents
Fluorescent Antibody Technique
Fever
Immunoglobulin G
Transplantation
Mothers
Genome
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Yoshikawa, Tetsushi ; Ihira, Masaru ; Suzuki, Kyoko ; Suga, Sadao ; Asano, Yoshizo ; Asonuma, Katsuhiro ; Tanaka, Koichi ; Nishiyama, Yukihiro. / Primary human herpesvirus 6 infection in liver transplant recipients. In: Journal of Pediatrics. 2001 ; Vol. 138, No. 6. pp. 921-925.
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Yoshikawa, T, Ihira, M, Suzuki, K, Suga, S, Asano, Y, Asonuma, K, Tanaka, K & Nishiyama, Y 2001, 'Primary human herpesvirus 6 infection in liver transplant recipients', Journal of Pediatrics, vol. 138, no. 6, pp. 921-925. https://doi.org/10.1067/mpd.2001.113622

Primary human herpesvirus 6 infection in liver transplant recipients. / Yoshikawa, Tetsushi; Ihira, Masaru; Suzuki, Kyoko; Suga, Sadao; Asano, Yoshizo; Asonuma, Katsuhiro; Tanaka, Koichi; Nishiyama, Yukihiro.

In: Journal of Pediatrics, Vol. 138, No. 6, 01.01.2001, p. 921-925.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Tetsushi

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