Abstract
We detected primary human herpesvirus 6 (HHV-6) infection in 5 infants who received living related liver transplantation from their HHV-6 seropositive mothers. Primary HHV-6 infection was confirmed by demonstrating the seroconversion of HHV-6 antibodies with an immunofluorescence assay, by the isolation of the virus, or both. Seroconversion of HHV-6 immunoglobulin G antibody was demonstrated in all 5 recipients. HHV-6 was isolated from 3 of the 5 recipients between 2 and 3 weeks after transplantation. Moreover, the virus genome was detected in plasma by polymerase chain reaction in 4 of the 5 recipients during the same period. Although the 5 recipients had pyrexia at the time of primary HHV-6 infection, none of the recipients had a skin rash after defervescence. Clinical symptoms disappeared without specific antiviral treatment in all but 1 of the recipients.
| Original language | English |
|---|---|
| Pages (from-to) | 921-925 |
| Number of pages | 5 |
| Journal | Journal of Pediatrics |
| Volume | 138 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 01-01-2001 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
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Primary human herpesvirus 6 infection in liver transplant recipients. / Yoshikawa, Tetsushi; Ihira, Masaru; Suzuki, Kyoko; Suga, Sadao; Asano, Yoshizo; Asonuma, Katsuhiro; Tanaka, Koichi; Nishiyama, Yukihiro.
In: Journal of Pediatrics, Vol. 138, No. 6, 01.01.2001, p. 921-925.Research output: Contribution to journal › Article
TY - JOUR
T1 - Primary human herpesvirus 6 infection in liver transplant recipients
AU - Yoshikawa, Tetsushi
AU - Ihira, Masaru
AU - Suzuki, Kyoko
AU - Suga, Sadao
AU - Asano, Yoshizo
AU - Asonuma, Katsuhiro
AU - Tanaka, Koichi
AU - Nishiyama, Yukihiro
PY - 2001/1/1
Y1 - 2001/1/1
N2 - We detected primary human herpesvirus 6 (HHV-6) infection in 5 infants who received living related liver transplantation from their HHV-6 seropositive mothers. Primary HHV-6 infection was confirmed by demonstrating the seroconversion of HHV-6 antibodies with an immunofluorescence assay, by the isolation of the virus, or both. Seroconversion of HHV-6 immunoglobulin G antibody was demonstrated in all 5 recipients. HHV-6 was isolated from 3 of the 5 recipients between 2 and 3 weeks after transplantation. Moreover, the virus genome was detected in plasma by polymerase chain reaction in 4 of the 5 recipients during the same period. Although the 5 recipients had pyrexia at the time of primary HHV-6 infection, none of the recipients had a skin rash after defervescence. Clinical symptoms disappeared without specific antiviral treatment in all but 1 of the recipients.
AB - We detected primary human herpesvirus 6 (HHV-6) infection in 5 infants who received living related liver transplantation from their HHV-6 seropositive mothers. Primary HHV-6 infection was confirmed by demonstrating the seroconversion of HHV-6 antibodies with an immunofluorescence assay, by the isolation of the virus, or both. Seroconversion of HHV-6 immunoglobulin G antibody was demonstrated in all 5 recipients. HHV-6 was isolated from 3 of the 5 recipients between 2 and 3 weeks after transplantation. Moreover, the virus genome was detected in plasma by polymerase chain reaction in 4 of the 5 recipients during the same period. Although the 5 recipients had pyrexia at the time of primary HHV-6 infection, none of the recipients had a skin rash after defervescence. Clinical symptoms disappeared without specific antiviral treatment in all but 1 of the recipients.
UR - http://www.scopus.com/inward/record.url?scp=0034970039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034970039&partnerID=8YFLogxK
U2 - 10.1067/mpd.2001.113622
DO - 10.1067/mpd.2001.113622
M3 - Article
C2 - 11391342
AN - SCOPUS:0034970039
VL - 138
SP - 921
EP - 925
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 6
ER -