Primary human herpesvirus 6 infection in liver transplant recipients

Tetsushi Yoshikawa, Masaru Ihira, Kyoko Suzuki, Sadao Suga, Yoshizo Asano, Katsuhiro Asonuma, Koichi Tanaka, Yukihiro Nishiyama

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


We detected primary human herpesvirus 6 (HHV-6) infection in 5 infants who received living related liver transplantation from their HHV-6 seropositive mothers. Primary HHV-6 infection was confirmed by demonstrating the seroconversion of HHV-6 antibodies with an immunofluorescence assay, by the isolation of the virus, or both. Seroconversion of HHV-6 immunoglobulin G antibody was demonstrated in all 5 recipients. HHV-6 was isolated from 3 of the 5 recipients between 2 and 3 weeks after transplantation. Moreover, the virus genome was detected in plasma by polymerase chain reaction in 4 of the 5 recipients during the same period. Although the 5 recipients had pyrexia at the time of primary HHV-6 infection, none of the recipients had a skin rash after defervescence. Clinical symptoms disappeared without specific antiviral treatment in all but 1 of the recipients.

Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalJournal of Pediatrics
Issue number6
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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