TY - JOUR
T1 - Primary human herpesvirus 6 infection in liver transplant recipients
AU - Yoshikawa, Tetsushi
AU - Ihira, Masaru
AU - Suzuki, Kyoko
AU - Suga, Sadao
AU - Asano, Yoshizo
AU - Asonuma, Katsuhiro
AU - Tanaka, Koichi
AU - Nishiyama, Yukihiro
N1 - Funding Information:
Supported in part by grants from Fujita Health University, a grant from Japan Society for the Promotion of Science (JSPS-RFTF97L00703), and also by a Grant-in-Aid for Scientific Research, the Ministry of Education, Science and Culture, Japan.
PY - 2001
Y1 - 2001
N2 - We detected primary human herpesvirus 6 (HHV-6) infection in 5 infants who received living related liver transplantation from their HHV-6 seropositive mothers. Primary HHV-6 infection was confirmed by demonstrating the seroconversion of HHV-6 antibodies with an immunofluorescence assay, by the isolation of the virus, or both. Seroconversion of HHV-6 immunoglobulin G antibody was demonstrated in all 5 recipients. HHV-6 was isolated from 3 of the 5 recipients between 2 and 3 weeks after transplantation. Moreover, the virus genome was detected in plasma by polymerase chain reaction in 4 of the 5 recipients during the same period. Although the 5 recipients had pyrexia at the time of primary HHV-6 infection, none of the recipients had a skin rash after defervescence. Clinical symptoms disappeared without specific antiviral treatment in all but 1 of the recipients.
AB - We detected primary human herpesvirus 6 (HHV-6) infection in 5 infants who received living related liver transplantation from their HHV-6 seropositive mothers. Primary HHV-6 infection was confirmed by demonstrating the seroconversion of HHV-6 antibodies with an immunofluorescence assay, by the isolation of the virus, or both. Seroconversion of HHV-6 immunoglobulin G antibody was demonstrated in all 5 recipients. HHV-6 was isolated from 3 of the 5 recipients between 2 and 3 weeks after transplantation. Moreover, the virus genome was detected in plasma by polymerase chain reaction in 4 of the 5 recipients during the same period. Although the 5 recipients had pyrexia at the time of primary HHV-6 infection, none of the recipients had a skin rash after defervescence. Clinical symptoms disappeared without specific antiviral treatment in all but 1 of the recipients.
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U2 - 10.1067/mpd.2001.113622
DO - 10.1067/mpd.2001.113622
M3 - Article
C2 - 11391342
AN - SCOPUS:0034970039
SN - 0022-3476
VL - 138
SP - 921
EP - 925
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 6
ER -