Probing, inhibition, and crystallographic characterization of metallo-β-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups

Hiromasa Kurosaki; Yoshihiro Yamaguchi; Hisami Yasuzawa; Wanchun Jin; Yuriko Yamagata; Yoshichika Arakawa

doi:10.1002/cmdc.200600115

Probing, inhibition, and crystallographic characterization of metallo-β-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups

Hiromasa Kurosaki, Yoshihiro Yamaguchi, Hisami Yasuzawa, Wanchun Jin, Yuriko Yamagata, Yoshichika Arakawa

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A series of fluorescent probes, N-(5-(dimethylamino)-1- naphthalenesulfonamido(alkyl)_n)-3-thiopropionamide (DansylC _nSHs), were rationally designed to detect and inhibit metallo-β-lactamase (IMP-1). These compounds were shown to function as fluorescent probes for and inhibitors of metallo-β-lactamases. The X-ray crystallographic structure shown indicates the potential of these agents for use as a new fluorescent probes for metallo-β-lactamases.

Original language	English
Pages (from-to)	969-972
Number of pages	4
Journal	ChemMedChem
Volume	1
Issue number	9
DOIs	https://doi.org/10.1002/cmdc.200600115
Publication status	Published - 09-2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
General Pharmacology, Toxicology and Pharmaceutics
Organic Chemistry

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10.1002/cmdc.200600115

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abstract = "A series of fluorescent probes, N-(5-(dimethylamino)-1- naphthalenesulfonamido(alkyl)n)-3-thiopropionamide (DansylC nSHs), were rationally designed to detect and inhibit metallo-β-lactamase (IMP-1). These compounds were shown to function as fluorescent probes for and inhibitors of metallo-β-lactamases. The X-ray crystallographic structure shown indicates the potential of these agents for use as a new fluorescent probes for metallo-β-lactamases.",

author = "Hiromasa Kurosaki and Yoshihiro Yamaguchi and Hisami Yasuzawa and Wanchun Jin and Yuriko Yamagata and Yoshichika Arakawa",

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AU - Kurosaki, Hiromasa

AU - Yamaguchi, Yoshihiro

AU - Yasuzawa, Hisami

AU - Jin, Wanchun

AU - Yamagata, Yuriko

AU - Arakawa, Yoshichika

PY - 2006/9

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ER -

Probing, inhibition, and crystallographic characterization of metallo-β-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups

Abstract

All Science Journal Classification (ASJC) codes

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