Probiotics-related Clostridium butyricum bacteraemia after COVID-19, confirmed by whole-genome sequencing

Yuya Kawamoto; Masahiro Suzuki; Mitsunaga Iwata; Yuki Uehara

doi:10.1136/bcr-2024-261578

Probiotics-related Clostridium butyricum bacteraemia after COVID-19, confirmed by whole-genome sequencing

Yuya Kawamoto
, Masahiro Suzuki
, Mitsunaga Iwata
, Yuki Uehara

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A man in his 70s was admitted to an intensive care unit with severe COVID-19 and treated with dexamethasone and tocilizumab. After recovery from COVID-19, he developed Clostridium butyricum bacteraemia and non-occlusive mesenteric ischaemia, with fatal outcome. He had been prescribed C. butyricum MIYAIRI 588 fine granules as probiotics for a month. The genome sequences of the C. butyricum isolate from the blood culture and C. butyricum MIYAIRI 588 fine granules were identical by single nucleotide polymorphism analysis. This is the first case of definitive probiotics-related C. butyricum bacteraemia after treatment of severe COVID-19.

Original language	English
Article number	e261578
Journal	BMJ Case Reports
Volume	17
Issue number	8
DOIs	https://doi.org/10.1136/bcr-2024-261578
Publication status	Published - 03-08-2024
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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10.1136/bcr-2024-261578

Cite this

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title = "Probiotics-related Clostridium butyricum bacteraemia after COVID-19, confirmed by whole-genome sequencing",

abstract = "A man in his 70s was admitted to an intensive care unit with severe COVID-19 and treated with dexamethasone and tocilizumab. After recovery from COVID-19, he developed Clostridium butyricum bacteraemia and non-occlusive mesenteric ischaemia, with fatal outcome. He had been prescribed C. butyricum MIYAIRI 588 fine granules as probiotics for a month. The genome sequences of the C. butyricum isolate from the blood culture and C. butyricum MIYAIRI 588 fine granules were identical by single nucleotide polymorphism analysis. This is the first case of definitive probiotics-related C. butyricum bacteraemia after treatment of severe COVID-19.",

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author = "Yuya Kawamoto and Masahiro Suzuki and Mitsunaga Iwata and Yuki Uehara",

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T1 - Probiotics-related Clostridium butyricum bacteraemia after COVID-19, confirmed by whole-genome sequencing

AU - Kawamoto, Yuya

AU - Suzuki, Masahiro

AU - Iwata, Mitsunaga

AU - Uehara, Yuki

N1 - Publisher Copyright: © BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2024/8/3

Y1 - 2024/8/3

N2 - A man in his 70s was admitted to an intensive care unit with severe COVID-19 and treated with dexamethasone and tocilizumab. After recovery from COVID-19, he developed Clostridium butyricum bacteraemia and non-occlusive mesenteric ischaemia, with fatal outcome. He had been prescribed C. butyricum MIYAIRI 588 fine granules as probiotics for a month. The genome sequences of the C. butyricum isolate from the blood culture and C. butyricum MIYAIRI 588 fine granules were identical by single nucleotide polymorphism analysis. This is the first case of definitive probiotics-related C. butyricum bacteraemia after treatment of severe COVID-19.

AB - A man in his 70s was admitted to an intensive care unit with severe COVID-19 and treated with dexamethasone and tocilizumab. After recovery from COVID-19, he developed Clostridium butyricum bacteraemia and non-occlusive mesenteric ischaemia, with fatal outcome. He had been prescribed C. butyricum MIYAIRI 588 fine granules as probiotics for a month. The genome sequences of the C. butyricum isolate from the blood culture and C. butyricum MIYAIRI 588 fine granules were identical by single nucleotide polymorphism analysis. This is the first case of definitive probiotics-related C. butyricum bacteraemia after treatment of severe COVID-19.

KW - Adult intensive care

KW - COVID-19

KW - Infection (gastroenterology)

KW - Mechanical ventilation

UR - https://www.scopus.com/pages/publications/85200530434

UR - https://www.scopus.com/pages/publications/85200530434#tab=citedBy

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DO - 10.1136/bcr-2024-261578

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AN - SCOPUS:85200530434

SN - 1757-790X

VL - 17

JO - BMJ Case Reports

JF - BMJ Case Reports

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ER -

Probiotics-related Clostridium butyricum bacteraemia after COVID-19, confirmed by whole-genome sequencing

Abstract

All Science Journal Classification (ASJC) codes

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