Problems in donor lung evaluation for transplantation with regard to airway infection

Yoshinori Okada, Y. Matsumura, Y. Hoshikawa, H. Oishi, M. Noda, T. Sado, K. Ishida, F. Hoshi, C. Endo, A. Miyamoto, T. Hosaka, H. Niikawa, K. Kaizu, T. Kondo

Research output: Contribution to journalArticle

Abstract

The shortage of donor organs has been 1 of the major obstacles to solid organ transplantation. Typical lung donor criteria include clear lung field on chest radiograph, adequate oxygenation, acceptable lung compliance, and satisfactory bronchoscopic findings. To extend usage of available donors, liberalization of donor lung selection criteria has been facilitated, however, marginal donor lungs must be used with discretion, because donor lung injury, especially that related to infection, has a potential leading to early post-operative death of the recipient. From March 2000 to December 2006, we evaluated 15 braindead donors and at least 1 of the lungs from 9 donors was judged suitable for transplantation. One of 9 recipients developed severe pneumonia cased by carbapenems-resistant Pseudomonas aeruginosa possibly originating from the donor lungs, eventually leading to death. The chest radiograph and oxygenation of the donor had been satisfactory, however, a moderate amount of mucopurulent secretions was observed by bronchoscopic inspection and the donor had been given a cefozopran for 9 days before the procurement operation. Remaining 8 recipients were free from air-way infection in the early postoperative period. We discuss the status and problems of donor lung evaluation for transplantation with regard to donor lung infection.

Original languageEnglish
Pages (from-to)976-981
Number of pages6
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume60
Issue number11
Publication statusPublished - 10-2007

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Okada, Y., Matsumura, Y., Hoshikawa, Y., Oishi, H., Noda, M., Sado, T., Ishida, K., Hoshi, F., Endo, C., Miyamoto, A., Hosaka, T., Niikawa, H., Kaizu, K., & Kondo, T. (2007). Problems in donor lung evaluation for transplantation with regard to airway infection. Kyobu geka. The Japanese journal of thoracic surgery, 60(11), 976-981.