Genetic testing has been developed to confirm various disorders and is applied widely as a fast-growing diagnostic tool. Laboratories performing genetic testing are needed to ensure quality assurance. Accurate and precise testing using nucleic acid extracted from various samples is important as pre-analysis as the results can be affected by bias introduced by sample preparations. The assays estimate the purification and isolation of nucleic acid from samples. Pre-analytic processes such as clinical sampling affected the outcome of genetic testing. Analysis of variance of gene expression revealed small but significant differences between handling methods. Great care has to be taken to measure pre-analytic changes in gene expression. Internal quality control programs for genetic testing are also needed. Thus, well-controlled sample processing and storage conditions are critical for sensitive and potentially quantitative analysis of genetic testing.
|Number of pages||7|
|Journal||Rinsho byori. The Japanese journal of clinical pathology|
|Publication status||Published - 03-2008|
All Science Journal Classification (ASJC) codes