Procollagen IIC-peptide as a marker for assessing mechanical risk factors of knee osteoarthritis

Effect of obesity and varus alignment

T. Kobayashi, Y. Yoshihara, Harumoto Yamada, K. Fujikawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective - To ascertain by cross sectional examination whether the concentration of procollagen IIC-peptide in joint fluid significantly correlates with mechanical risk factors of knee osteoarthritis (OA), such as obesity (body mass index) and varus alignment (lateral femorotibial angle). Methods - The concentrations of procollagen IIC-propeptide in synovial fluid were measured by a sandwich enzyme immunoassay of 65 patients with the same radiological stage of primary knee OA - that is, Ahlbak stage I. The relations between procollagen IIC-peptide and body mass index and lateral femorotibial angle were examined using simple regression analysis and multiple regression analysis. Results - Significant positive correlations were found between procollagen IIC-propeptide concentrations and body mass index (r=0.479, p<0.0001), and between procollagen IIC-propeptide concentrations and lateral femorotibial angle (r=0.375, p=0.0021). Significant correlations were also found by multiple regression analysis. The multiple correlation coefficient of body mass index and femorotibial lateral angle to the procollagen IIC-propeptide concentrations was 0.547 (p<0.0001). Conclusions - The findings suggest that synthesis of type II collagen by chondrocytes is enhanced by abnormal mechanical stress, in this case obesity and varus alignment. It is concluded that procollagen IIC-propeptide concentrations in joint fluid are a useful marker of early OA.

Original languageEnglish
Pages (from-to)982-984
Number of pages3
JournalAnnals of the Rheumatic Diseases
Volume59
Issue number12
DOIs
Publication statusPublished - 27-12-2000
Externally publishedYes

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Procollagen
Knee Osteoarthritis
Obesity
Peptides
Body Mass Index
Regression analysis
Regression Analysis
Fluids
Joints
Mechanical Stress
Collagen Type II
Synovial Fluid
Chondrocytes
Immunoenzyme Techniques
Osteoarthritis
Enzymes

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Procollagen IIC-peptide as a marker for assessing mechanical risk factors of knee osteoarthritis: Effect of obesity and varus alignment",
abstract = "Objective - To ascertain by cross sectional examination whether the concentration of procollagen IIC-peptide in joint fluid significantly correlates with mechanical risk factors of knee osteoarthritis (OA), such as obesity (body mass index) and varus alignment (lateral femorotibial angle). Methods - The concentrations of procollagen IIC-propeptide in synovial fluid were measured by a sandwich enzyme immunoassay of 65 patients with the same radiological stage of primary knee OA - that is, Ahlbak stage I. The relations between procollagen IIC-peptide and body mass index and lateral femorotibial angle were examined using simple regression analysis and multiple regression analysis. Results - Significant positive correlations were found between procollagen IIC-propeptide concentrations and body mass index (r=0.479, p<0.0001), and between procollagen IIC-propeptide concentrations and lateral femorotibial angle (r=0.375, p=0.0021). Significant correlations were also found by multiple regression analysis. The multiple correlation coefficient of body mass index and femorotibial lateral angle to the procollagen IIC-propeptide concentrations was 0.547 (p<0.0001). Conclusions - The findings suggest that synthesis of type II collagen by chondrocytes is enhanced by abnormal mechanical stress, in this case obesity and varus alignment. It is concluded that procollagen IIC-propeptide concentrations in joint fluid are a useful marker of early OA.",
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Procollagen IIC-peptide as a marker for assessing mechanical risk factors of knee osteoarthritis : Effect of obesity and varus alignment. / Kobayashi, T.; Yoshihara, Y.; Yamada, Harumoto; Fujikawa, K.

In: Annals of the Rheumatic Diseases, Vol. 59, No. 12, 27.12.2000, p. 982-984.

Research output: Contribution to journalArticle

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T2 - Effect of obesity and varus alignment

AU - Kobayashi, T.

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AU - Yamada, Harumoto

AU - Fujikawa, K.

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