Production and functions of IL-17 in microglia

Jun Kawanokuchi; Kouki Shimizu; Atsumi Nitta; Kiyofumi Yamada; Tetsuya Mizuno; Hideyuki Takeuchi; Akio Suzumura

doi:10.1016/j.jneuroim.2007.11.006

Production and functions of IL-17 in microglia

Jun Kawanokuchi, Kouki Shimizu, Atsumi Nitta, Kiyofumi Yamada, Tetsuya Mizuno, Hideyuki Takeuchi, Akio Suzumura

Research output: Contribution to journal › Article › peer-review

213 Citations (Scopus)

Abstract

Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6, macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1β. Because microglia produce IL-1β and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system.

Original language	English
Pages (from-to)	54-61
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	194
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.11.006
Publication status	Published - 02-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2007.11.006

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title = "Production and functions of IL-17 in microglia",

abstract = "Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6, macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1β. Because microglia produce IL-1β and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system.",

author = "Jun Kawanokuchi and Kouki Shimizu and Atsumi Nitta and Kiyofumi Yamada and Tetsuya Mizuno and Hideyuki Takeuchi and Akio Suzumura",

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T1 - Production and functions of IL-17 in microglia

AU - Kawanokuchi, Jun

AU - Shimizu, Kouki

AU - Nitta, Atsumi

AU - Yamada, Kiyofumi

AU - Mizuno, Tetsuya

AU - Takeuchi, Hideyuki

AU - Suzumura, Akio

PY - 2008/2

Y1 - 2008/2

N2 - Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6, macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1β. Because microglia produce IL-1β and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system.

AB - Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6, macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1β. Because microglia produce IL-1β and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system.

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Production and functions of IL-17 in microglia

Abstract

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