Profiles of vitamin D insufficiency and deficiency in Japanese men and women: Association with biological, environmental, and nutritional factors and coexisting disorders: The ROAD study

N. Yoshimura, S. Muraki, H. Oka, M. Morita, Harumoto Yamada, S. Tanaka, H. Kawaguchi, K. Nakamura, T. Akune

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Abstract

Assessments of serum 25-hydroxyvitamin D levels in 1,683 Japanese from a population-based cohort revealed prevalences of vitamin D insufficiency and deficiency were 81.3 and 1.2 %, respectively. Vitamin D deficiency was significantly associated with female sex, examined month, current smoking, lack of regular walking, higher intact parathyroid hormone (iPTH), and poor daily vitamin D intake. Introduction: To clarify the characteristics of subjects with vitamin D insufficiency and deficiency among men and women in the general Japanese population. Methods: We initiated research on osteoarthritis/ osteoporosis against disability (ROAD), a large-scale population-based cohort study, in 2005-2007. Blood examination was performed to measure serum 25-hydroxyvitamin D (25D) and iPTH levels and biochemical markers of bone turnover in 1,683 participants (595 men, 1,088 women). Participants completed an interviewer-administered questionnaire, measurements of bone mineral density, and x-ray examination. Vitamin D deficiency and insufficiency were defined by serum 25D levels <10 and ≥10 but <30 ng/mL, respectively. Results: The prevalence of vitamin D insufficiency and deficiency was 81.3 and 1.2 %, respectively. Multinominal logistic regression analyses using potentially confounding variables revealed vitamin D insufficiency was significantly associated with age (+1 year, relative risk ratio, 0.98; 95 % confidence interval, 0.96-0.99), gender (women vs. men, 2.28; 1.59-3.30), residing areas (coastal area vs. mountainous area, 0.58; 0.41-0.81), examined month (October, November, December vs. January, 0.51; 0.34-0.76), and serum levels of iPTH (+1 pg/mL, 1.02; 1.01-1.03). Vitamin D deficiency was significantly characterised by female sex (20.5; 3.1-136.7), examined month (0.28; 0.09-0.95), current smoking habit (6.39; 1.78-23.0), lack of regular outside walking (3.96; 1.34-11.7), higher iPTH (1.02; 1.01-1.03) and poor daily vitamin D intake (+10 μg/day, 0.48; 0.24-0.93). Conclusions: A high prevalence of vitamin D insufficiency and a low prevalence of vitamin D deficiency were found in Japanese men and women, and the characteristics of vitamin D status were clarified.

Original languageEnglish
Pages (from-to)2775-2787
Number of pages13
JournalOsteoporosis International
Volume24
Issue number11
DOIs
Publication statusPublished - 01-11-2013

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Vitamin D Deficiency
Vitamin D
Parathyroid Hormone
Serum
Walking
Smoking
Population
Confounding Factors (Epidemiology)
Bone Remodeling
Osteoarthritis
Bone Density
Osteoporosis
Habits
Cohort Studies
Biomarkers
Logistic Models
Odds Ratio
Regression Analysis
X-Rays
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

@article{1b6c596d6cd840799cc8b01e06670f2a,
title = "Profiles of vitamin D insufficiency and deficiency in Japanese men and women: Association with biological, environmental, and nutritional factors and coexisting disorders: The ROAD study",
abstract = "Assessments of serum 25-hydroxyvitamin D levels in 1,683 Japanese from a population-based cohort revealed prevalences of vitamin D insufficiency and deficiency were 81.3 and 1.2 {\%}, respectively. Vitamin D deficiency was significantly associated with female sex, examined month, current smoking, lack of regular walking, higher intact parathyroid hormone (iPTH), and poor daily vitamin D intake. Introduction: To clarify the characteristics of subjects with vitamin D insufficiency and deficiency among men and women in the general Japanese population. Methods: We initiated research on osteoarthritis/ osteoporosis against disability (ROAD), a large-scale population-based cohort study, in 2005-2007. Blood examination was performed to measure serum 25-hydroxyvitamin D (25D) and iPTH levels and biochemical markers of bone turnover in 1,683 participants (595 men, 1,088 women). Participants completed an interviewer-administered questionnaire, measurements of bone mineral density, and x-ray examination. Vitamin D deficiency and insufficiency were defined by serum 25D levels <10 and ≥10 but <30 ng/mL, respectively. Results: The prevalence of vitamin D insufficiency and deficiency was 81.3 and 1.2 {\%}, respectively. Multinominal logistic regression analyses using potentially confounding variables revealed vitamin D insufficiency was significantly associated with age (+1 year, relative risk ratio, 0.98; 95 {\%} confidence interval, 0.96-0.99), gender (women vs. men, 2.28; 1.59-3.30), residing areas (coastal area vs. mountainous area, 0.58; 0.41-0.81), examined month (October, November, December vs. January, 0.51; 0.34-0.76), and serum levels of iPTH (+1 pg/mL, 1.02; 1.01-1.03). Vitamin D deficiency was significantly characterised by female sex (20.5; 3.1-136.7), examined month (0.28; 0.09-0.95), current smoking habit (6.39; 1.78-23.0), lack of regular outside walking (3.96; 1.34-11.7), higher iPTH (1.02; 1.01-1.03) and poor daily vitamin D intake (+10 μg/day, 0.48; 0.24-0.93). Conclusions: A high prevalence of vitamin D insufficiency and a low prevalence of vitamin D deficiency were found in Japanese men and women, and the characteristics of vitamin D status were clarified.",
author = "N. Yoshimura and S. Muraki and H. Oka and M. Morita and Harumoto Yamada and S. Tanaka and H. Kawaguchi and K. Nakamura and T. Akune",
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Profiles of vitamin D insufficiency and deficiency in Japanese men and women : Association with biological, environmental, and nutritional factors and coexisting disorders: The ROAD study. / Yoshimura, N.; Muraki, S.; Oka, H.; Morita, M.; Yamada, Harumoto; Tanaka, S.; Kawaguchi, H.; Nakamura, K.; Akune, T.

In: Osteoporosis International, Vol. 24, No. 11, 01.11.2013, p. 2775-2787.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Profiles of vitamin D insufficiency and deficiency in Japanese men and women

T2 - Association with biological, environmental, and nutritional factors and coexisting disorders: The ROAD study

AU - Yoshimura, N.

AU - Muraki, S.

AU - Oka, H.

AU - Morita, M.

AU - Yamada, Harumoto

AU - Tanaka, S.

AU - Kawaguchi, H.

AU - Nakamura, K.

AU - Akune, T.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Assessments of serum 25-hydroxyvitamin D levels in 1,683 Japanese from a population-based cohort revealed prevalences of vitamin D insufficiency and deficiency were 81.3 and 1.2 %, respectively. Vitamin D deficiency was significantly associated with female sex, examined month, current smoking, lack of regular walking, higher intact parathyroid hormone (iPTH), and poor daily vitamin D intake. Introduction: To clarify the characteristics of subjects with vitamin D insufficiency and deficiency among men and women in the general Japanese population. Methods: We initiated research on osteoarthritis/ osteoporosis against disability (ROAD), a large-scale population-based cohort study, in 2005-2007. Blood examination was performed to measure serum 25-hydroxyvitamin D (25D) and iPTH levels and biochemical markers of bone turnover in 1,683 participants (595 men, 1,088 women). Participants completed an interviewer-administered questionnaire, measurements of bone mineral density, and x-ray examination. Vitamin D deficiency and insufficiency were defined by serum 25D levels <10 and ≥10 but <30 ng/mL, respectively. Results: The prevalence of vitamin D insufficiency and deficiency was 81.3 and 1.2 %, respectively. Multinominal logistic regression analyses using potentially confounding variables revealed vitamin D insufficiency was significantly associated with age (+1 year, relative risk ratio, 0.98; 95 % confidence interval, 0.96-0.99), gender (women vs. men, 2.28; 1.59-3.30), residing areas (coastal area vs. mountainous area, 0.58; 0.41-0.81), examined month (October, November, December vs. January, 0.51; 0.34-0.76), and serum levels of iPTH (+1 pg/mL, 1.02; 1.01-1.03). Vitamin D deficiency was significantly characterised by female sex (20.5; 3.1-136.7), examined month (0.28; 0.09-0.95), current smoking habit (6.39; 1.78-23.0), lack of regular outside walking (3.96; 1.34-11.7), higher iPTH (1.02; 1.01-1.03) and poor daily vitamin D intake (+10 μg/day, 0.48; 0.24-0.93). Conclusions: A high prevalence of vitamin D insufficiency and a low prevalence of vitamin D deficiency were found in Japanese men and women, and the characteristics of vitamin D status were clarified.

AB - Assessments of serum 25-hydroxyvitamin D levels in 1,683 Japanese from a population-based cohort revealed prevalences of vitamin D insufficiency and deficiency were 81.3 and 1.2 %, respectively. Vitamin D deficiency was significantly associated with female sex, examined month, current smoking, lack of regular walking, higher intact parathyroid hormone (iPTH), and poor daily vitamin D intake. Introduction: To clarify the characteristics of subjects with vitamin D insufficiency and deficiency among men and women in the general Japanese population. Methods: We initiated research on osteoarthritis/ osteoporosis against disability (ROAD), a large-scale population-based cohort study, in 2005-2007. Blood examination was performed to measure serum 25-hydroxyvitamin D (25D) and iPTH levels and biochemical markers of bone turnover in 1,683 participants (595 men, 1,088 women). Participants completed an interviewer-administered questionnaire, measurements of bone mineral density, and x-ray examination. Vitamin D deficiency and insufficiency were defined by serum 25D levels <10 and ≥10 but <30 ng/mL, respectively. Results: The prevalence of vitamin D insufficiency and deficiency was 81.3 and 1.2 %, respectively. Multinominal logistic regression analyses using potentially confounding variables revealed vitamin D insufficiency was significantly associated with age (+1 year, relative risk ratio, 0.98; 95 % confidence interval, 0.96-0.99), gender (women vs. men, 2.28; 1.59-3.30), residing areas (coastal area vs. mountainous area, 0.58; 0.41-0.81), examined month (October, November, December vs. January, 0.51; 0.34-0.76), and serum levels of iPTH (+1 pg/mL, 1.02; 1.01-1.03). Vitamin D deficiency was significantly characterised by female sex (20.5; 3.1-136.7), examined month (0.28; 0.09-0.95), current smoking habit (6.39; 1.78-23.0), lack of regular outside walking (3.96; 1.34-11.7), higher iPTH (1.02; 1.01-1.03) and poor daily vitamin D intake (+10 μg/day, 0.48; 0.24-0.93). Conclusions: A high prevalence of vitamin D insufficiency and a low prevalence of vitamin D deficiency were found in Japanese men and women, and the characteristics of vitamin D status were clarified.

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U2 - 10.1007/s00198-013-2372-z

DO - 10.1007/s00198-013-2372-z

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AN - SCOPUS:84890563937

VL - 24

SP - 2775

EP - 2787

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

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